标题
Druggable sensors of the unfolded protein response
作者
关键词
-
出版物
Nature Chemical Biology
Volume 10, Issue 11, Pages 892-901
出版商
Springer Nature
发表日期
2014-10-18
DOI
10.1038/nchembio.1664
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress
- (2014) Rajarshi Ghosh et al. CELL
- XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
- (2014) Xi Chen et al. NATURE
- Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors
- (2014) Mario Sanches et al. Nature Communications
- Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma
- (2013) Chungyee Leung-Hagesteijn et al. CANCER CELL
- Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
- (2013) C. Atkins et al. CANCER RESEARCH
- Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
- (2013) J. A. Moreno et al. Science Translational Medicine
- Endoplasmic Reticulum Stress, Pancreatic -Cell Degeneration, and Diabetes
- (2013) F. R. Papa Cold Spring Harbor Perspectives in Medicine
- Structural Basis of the Unfolded Protein Response
- (2012) Alexei Korennykh et al. Annual Review of Cell and Developmental Biology
- Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma
- (2012) Jing-li Gu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Blockade of XBP1 splicing by inhibition of IRE1 is a promising therapeutic option in multiple myeloma
- (2012) N. Mimura et al. BLOOD
- IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
- (2012) Alana G. Lerner et al. Cell Metabolism
- The impact of the unfolded protein response on human disease
- (2012) Shiyu Wang et al. JOURNAL OF CELL BIOLOGY
- Endoplasmic reticulum dysfunction in neurological disease
- (2012) Benoit D Roussel et al. LANCET NEUROLOGY
- Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors
- (2012) Likun Wang et al. Nature Chemical Biology
- The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
- (2012) B. C. S. Cross et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IRE1 Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2
- (2012) J.-P. Upton et al. SCIENCE
- New insights into ER stress-induced insulin resistance
- (2012) Mélissa Flamment et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
- (2011) Alexei V Korennykh et al. BMC BIOLOGY
- Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
- (2011) Maruf M U Ali et al. EMBO JOURNAL
- Response of myeloma to the proteasome inhibitor bortezomib is correlated with the unfolded protein response regulator XBP-1
- (2011) S. C. W. Ling et al. HAEMATOLOGICA
- Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease
- (2011) Kori Volkmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Initial genome sequencing and analysis of multiple myeloma
- (2011) Michael A. Chapman et al. NATURE
- Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
- (2011) Ira Tabas et al. NATURE CELL BIOLOGY
- Dual and opposing roles of the unfolded protein response regulated by IRE1 and XBP1 in proinsulin processing and insulin secretion
- (2011) A.-H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum
- (2011) M. H. Smith et al. SCIENCE
- The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- (2011) P. Walter et al. SCIENCE
- Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response
- (2011) B. M. Gardner et al. SCIENCE
- Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
- (2010) I. Papandreou et al. BLOOD
- Signaling cell death from the endoplasmic reticulum stress response
- (2010) Gordon C Shore et al. CURRENT OPINION IN CELL BIOLOGY
- Coxsackievirus B3 Infection Activates the Unfolded Protein Response and Induces Apoptosis through Downregulation of p58IPK and Activation of CHOP and SREBP1
- (2010) H. M. Zhang et al. JOURNAL OF VIROLOGY
- The BCL-2 Family Reunion
- (2010) Jerry E. Chipuk et al. MOLECULAR CELL
- BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response
- (2010) David Pincus et al. PLOS BIOLOGY
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
- The Role of Mitochondria in Apoptosis
- (2009) Chunxin Wang et al. Annual Review of Genetics
- IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
- (2009) Dan Han et al. CELL
- BH3-only proteins and their roles in programmed cell death
- (2009) M Giam et al. ONCOGENE
- Divergent Effects of PERK and IRE1 Signaling on Cell Viability
- (2009) Jonathan H. Lin et al. PLoS One
- Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1
- (2009) E. van Anken et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions
- (2008) Philip I. Merksamer et al. CELL
- Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing
- (2008) Kenneth P.K. Lee et al. CELL
- Protein quality control in the early secretory pathway
- (2008) Tiziana Anelli et al. EMBO JOURNAL
- The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes
- (2008) Donalyn Scheuner et al. ENDOCRINE REVIEWS
- ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
- (2008) H. Nishitoh et al. GENES & DEVELOPMENT
- Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress
- (2008) J.-P. Upton et al. MOLECULAR AND CELLULAR BIOLOGY
- The unfolded protein response signals through high-order assembly of Ire1
- (2008) Alexei V. Korennykh et al. NATURE
- Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
- (2008) Julie D. Atkin et al. NEUROBIOLOGY OF DISEASE
- A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress
- (2007) Dan Han et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started