Architectural and thermodynamic principles underlying intramembrane protease function

The Tetrameric α-Helical Membrane Protein GlpF Unfolds via a Dimeric Folding Intermediate

(2011) Anbazhagan Veerappan et al.   BIOCHEMISTRY

Rhomboid Family Pseudoproteases Use the ER Quality Control Machinery to Regulate Intercellular Signaling

(2011) Markus Zettl et al.   CELL

Structure of Rhomboid Protease in a Lipid Environment

(2011) Kutti R. Vinothkumar   JOURNAL OF MOLECULAR BIOLOGY

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

(2011) Ethan J Greenblatt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis

(2010) Sinisa Urban   BIOCHEMICAL JOURNAL

The Contribution of a Covalently Bound Cofactor to the Folding and Thermodynamic Stability of an Integral Membrane Protein

(2010) Paul Curnow et al.   JOURNAL OF MOLECULAR BIOLOGY

Unfolding free energy of a two-domain transmembrane sugar transport protein

(2010) H. E. Findlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramembrane Cleavage of AMA1 Triggers Toxoplasma to Switch from an Invasive to a Replicative Mode

(2010) J. M. Santos et al.   SCIENCE

The Effect of Loops on the Structural Organization of α-Helical Membrane Proteins

(2009) Oznur Tastan et al.   BIOPHYSICAL JOURNAL

Intramembrane Proteolysis

(2009) Michael S. Wolfe   CHEMICAL REVIEWS

Folding scene investigation: membrane proteins

(2009) Paula J Booth et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intramembrane Proteolysis by Signal Peptide Peptidases: A Comparative Discussion of GXGD-type Aspartyl Proteases

(2009) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Similar Energetic Contributions of Packing in the Core of Membrane and Water-Soluble Proteins

(2009) Nathan H. Joh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural imperatives impose diverse evolutionary constraints on helical membrane proteins

(2009) A. Oberai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhomboid Protease Dynamics and Lipid Interactions

(2009) Ana-Nicoleta Bondar et al.   STRUCTURE

Protein Self-Assembly and Lipid Binding in the Folding of the Potassium Channel KcsA†

(2008) Francisco N. Barrera et al.   BIOCHEMISTRY

In vivo analysis reveals substrate-gating mutants of a rhomboid intramembrane protease display increased activity in living cells

(2008) Sinisa Urban et al.   BIOLOGICAL CHEMISTRY

Intramembrane Proteolysis of GXGD-type Aspartyl Proteases Is Slowed by a Familial Alzheimer Disease-like Mutation

(2008) Regina Fluhrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins

(2008) Nathan HyunJoong Joh et al.   NATURE