Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Selective Insulin Receptor Modulators (SIRM): A New Class of Antidiabetes Drugs?

(2012) Riccardo Vigneri et al.   DIABETES

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

(2012) Vinay Bhaskar et al.   DIABETES

Allosteric antibody inhibition of human hepsin protease

(2011) Tobias Koschubs et al.   BIOCHEMICAL JOURNAL

Receptor Antibodies as Novel Therapeutics for Diabetes

(2011) S. Ussar et al.   Science Translational Medicine

Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptor

(2010) M Cazorla et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Autoimmune Forms of Hypoglycemia

(2009) Beatrice C. Lupsa et al.   MEDICINE

Metabolic effects of various antidiabetic and hypolipidaemic agents on a high-fat diet and multiple low-dose streptozocin (MLDS) mouse model of diabetes

(2008) Dakshinamoorty Kandasamy Arulmozhi et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF‐1 receptor and androgen dependent growth of LAPC‐4 prostate cancer cells

(2008) Charles J. Ryan et al.   PROSTATE

The role of insulin receptors and IGF-I receptors in cancer and other diseases

(2008) Francesco Frasca et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

High-affinity binding measurements of antibodies to cell-surface-expressed antigens

(2007) Palaniswami Rathanaswami et al.   ANALYTICAL BIOCHEMISTRY