Article
Pharmacology & Pharmacy
Vivek K. Kashyap, Godwin Peasah-Darkwah, Anupam Dhasmana, Meena Jaggi, Murali M. Yallapu, Subhash C. Chauhan
Summary: This review highlights the potential of Withania somnifera (WS) as an anticancer and immunomodulatory molecule. Several preclinical studies have shown that WS can prevent or slow the progression of cancer originating from various organs. However, stability, bioavailability, and target specificity are major obstacles in the application of WS for cancer therapy.
Article
Agronomy
Zishan Ahmad, Arjumend Shaheen, Adla Wasi, Shams ur Rehman, Sabaha Tahseen, Muthusamy Ramakrishnan, Anamica Upadhyay, Irfan Bashir Ganie, Anwar Shahzad, Yulong Ding
Summary: This article provides an overview of the medicinal properties of Withania coagulans and discusses conservation strategies and innovative approaches for sustainable utilization.
Article
Plant Sciences
Ji Won Ha, Jae Sik Yu, Bum Soo Lee, Dong-Min Kang, Mi-Jeong Ahn, Jung Kyu Kim, Ki Hyun Kim
Summary: This study found that Withania somnifera root is rich in withanolides, which exhibit antioxidant activity and weak anti-Helicobacter pylori activity.
Article
Biochemistry & Molecular Biology
Sartaz Begum, Daniel M. Shadrack, Ferister M. Joseph, Valence M. K. Ndensendo
Summary: Medicinal plants, including Withania somnifera, have long been used as medicine for treating bacterial infections. This study found that a compound from Withania somnifera leaf extract, withanolide C, showed strong antibacterial activity against S. aureus by inhibiting DNA gyrase. This discovery provides a basis for the development of novel antimicrobial agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Medicinal
Bum Soo Lee, Min Jeong Yoo, Heesun Kang, Seoung Rak Lee, Sil Kim, Jae Sik Yu, Jin-Chul Kim, Tae Su Jang, Changhyun Pang, Ki Hyun Kim
Summary: A new withanolide compound, named withasomniferol D (1), isolated from Withania somnifera roots, was found to exhibit anti-adipogenic activity, showing potential for the treatment of obesity and related metabolic diseases.
Review
Chemistry, Multidisciplinary
Sunil Shinde, Arun Kumar Balasubramaniam, Vallabh Mulay, Ganesh Saste, Aboli Girme, Lal Hingorani
Summary: This article highlights the therapeutic value and nutritional properties of Ashwagandha, also known as Indian ginseng. It discusses the importance of plant part and extraction techniques in determining the quality of the product and explores the potential applications in dietary supplements and functional foods.
Article
Agricultural Engineering
Varsha Tomar, Neeladrisingha Das, Harsh Chauhan, Partha Roy, Debabrata Sircar
Summary: The study aimed to increase the production of bioactive withanolides in field-grown plants of Withania somnifera using exogenous elicitor-treatment as an effective strategy.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Sachin Ashok Thorat, Poornima Poojari, Arya Kaniyassery, Kodsara Ramachandra Kiran, Kapaettu Satyamoorthy, Krishna Kishore Mahato, Annamalai Muthusamy
Summary: The study investigated the effects of red laser irradiation on the germination, growth characteristics, pigment contents, and withanolide content in Withania somnifera seeds. The results showed that laser irradiation promoted seed germination, growth characteristics, and the production of bioactive compounds. Different dosages of laser irradiation led to improvements in germination rate, plant growth, and withanolide production.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Agricultural Engineering
Prince Choyal, Maharishi Tomar, Virendra Singh Rana, Manish Kumar Suthar, Kailashpati Tripathi, Kuldeepsingh A. Kalariya, Ponnuchamy Manivel, Bhupinder Singh
Summary: The study showed that altering the source-sink relationship can effectively increase root yields. Chemical gametocide and mechanical deflowering significantly increased root biomass and withanolides content.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Virology
Pratiksha Jadaun, R. Harshithkumar, Shraddha Y. Gaikwad, Chandrabhan Seniya, Swapnil Borse, Ashish A. Gawai, Preeti Chavan-Gautam, Girish Tillu, Anupam Mukherjee
Summary: The hydroalcoholic and aqueous extracts of Withania somnifera roots are potent inhibitors of HIV-1 infection, and specific active compounds within the extracts have been identified. This study provides evidence for the potential of Withania somnifera extracts and their active compounds as anti-HIV-1 agents.
Article
Plant Sciences
Sachin Ashok Thorat, Arya Kaniyassery, Poornima Poojari, Melissa Rangel, Shashikala Tantry, Kodsara Ramachandra Kiran, Manjunath B. Joshi, Padmalatha S. Rai, Anna-Maria Botha, Annamalai Muthusamy
Summary: This study investigated the influence of plant growth regulators on the growth and biosynthesis of bioactive compounds in Ashwagandha at different growth stages. The results show that plant growth regulators can promote plant growth and the synthesis of important bioactive compounds like withanolides.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Manali Singh, Shivani Bhutani, Nisha Dinkar, Anita Mishra, Kahkashan Perveen, Alanoud T. Alfagham, Mehrun Nisha Khanam, Santosh Chandra Bhatt, Deep Chandra Suyal
Summary: The study aims to increase the production of antioxidants withaferin A and withanolide A in W. somnifera using the aquaponics technique. The results show that the Poshita variety has more potential in increasing the production of these compounds in the aquaponics system, with the root being the best source.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Lakee Sharma, Bipin Maurya, Sneha Singh, Shashi Pandey-Rai
Summary: Micropropagated shoots of Withania somnifera responded differentially to different NaCl concentrations, with the highest production of secondary metabolite (withaferin A) observed at 150 mM NaCl. Enhanced production of secondary metabolites is important due to the increasing reliance on herbal-based medicines. NaCl has been shown to act as an abiotic elicitor for enhancing phytochemical compounds. This study found that the best concentration of BAP hormone for maximum yield was 2 mg L-1, and the microshoots treated with varying NaCl concentrations showed changes in morphological, physico-biochemical, and molecular characteristics.
PLANT CELL TISSUE AND ORGAN CULTURE
(2023)
Article
Plant Sciences
Priya Pathak, Prachi Shukla, Jitendra S. Kanshana, Kumaravelu Jagavelu, Neelam S. Sangwan, Anil K. Dwivedi, Madhu Dikshit
Summary: The study aimed to evaluate the vasoprotective potential of NM and its biomarker compound WA using rat aortic rings and EA.hy926 endothelial cells. NM and WA exerted moderate vasorelaxant effect in rat aortic rings, mediated by enhanced eNOS phosphorylation and NO/cGMP pathway. The vasorelaxant property of NM is beneficial for its neuroprotective potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dahae Lee, Jae Sik Yu, Ji Won Ha, Seoung Rak Lee, Bum Soo Lee, Jin-Chul Kim, Jung Kyu Kim, Ki Sung Kang, Ki Hyun Kim
Summary: This study investigated the cytotoxicity of Withania somnifera against human hepatocellular carcinoma (HCC) cells and identified potential antitumoral withanolide glycosides. The study also elucidated the molecular mechanisms of these bioactive compounds and found that they induced apoptosis and inhibited angiogenesis in HCC cells.
Article
Biochemistry & Molecular Biology
Hosakatte Niranjana Murthy, Guggalada Govardhana Yadav, Sathish Shekhappa Kadapatti, M. Sandhya
Summary: The objective of this study was to evaluate the phytochemicals and antioxidant potential of Garcinia indica resin. Acetone and methanol extracts contain high amounts of phenolics and flavonoids, while methanol extract has the highest alkaloid content. GC-MS analysis identified terpenoids as the major compounds in acetone extract. Both acetone and methanol extracts showed excellent antioxidant activity. This study suggests that G. indica resin can be used for medicinal applications.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hosakatte Niranjana Murthy, Kadanthottu Sebastian Joseph, Kee Yoeup Paek, So Young Park
Summary: This article introduces the major groups of medicinal plants in the Rubia genus, such as Rubia cordifolia, Rubia tinctorum, and Rubia akane. These plants contain anthraquinones (AQs), particularly alizarin and purpurin, which have various pharmacological effects. AQs have been used as natural dyes and color additives in industries. Different techniques and approaches, including cell and organ cultures, have been used to produce biomass and secondary metabolites from Rubia species. Bioreactor cultures have also been emphasized as a method to grow cells for AQ production.
Review
Biotechnology & Applied Microbiology
Hosakatte Niranjana Murthy, Kadanthottu Sebastian Joseph, Kee Yoeup Paek, So Young Park
Summary: Since ancient times, Morinda species, especially Morinda citrifolia, have been used for therapeutic purposes. Various natural substances with bioactivity, such as iridoids, anthraquinones, coumarins, flavonoids, lignans, phytosterols, and carotenoids, have been identified. Among these, anthraquinone derivatives are the most important and are utilized as natural coloring agents with medicinal functions. This article provides a summary of the biotechnological methods used for the bioproduction of anthraquinone derivatives using cell and organ cultures of Morinda species. The production of these chemicals in bioreactor cultures is also discussed.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Serisha Gangaram, Yougasphree Naidoo, Yaser Hassan Dewir, Moganavelli Singh, Johnson Lin, Hosakatte Niranjana Murthy
Summary: This study characterized the phytochemical compounds and antibacterial efficacies of Barleria albostellata, a relatively understudied shrub in South Africa. The crude leaf and stem extracts exhibited antibacterial activity against various pathogenic microorganisms, and analysis revealed the presence of bioactive compounds with potential medicinal value. These findings highlight the potential of B. albostellata as a source for novel antibacterial agents.
Article
Plant Sciences
Ji-Hye Kim, Jong-Eun Han, Hosakatte Niranjana Murthy, Ja-Young Kim, Mi-Jin Kim, Taek-Kyu Jeong, So-Young Park
Summary: Sageretia thea was cultivated with the aim of increasing the production of phenolic compounds in plant cell suspension cultures. Optimum callus was induced and methyl jasmonate was found to be a suitable elicitor for phenolic accumulation in cell suspensions. The use of balloon-type bioreactors resulted in the highest biomass yields after four weeks of cultivation.
Article
Plant Sciences
Oluwatosin Temilade Adu, Yougasphree Naidoo, Johnson Lin, Depika Dwarka, John Mellem, Hosakatte Niranjana Murthy, Yaser Hassan Dewir
Summary: This study examined the nutritional properties and cytotoxic effects of D. villosa. The extracts and nanoparticles of D. villosa showed cytotoxic activity against cancerous cell lines, particularly MCF-7 and A549.
Article
Biology
Dayanand Dalawai, Hosakatte Niranjana Murthy, Yaser Hassan Dewir, Joseph Kadanthottu Sebastian, Anish Nag
Summary: This study determined the phytochemical composition and bioactive chemical components of Andrographis macrobotrys using GC-MS, and evaluated the antioxidant potential of its extracts. The results showed that the stem extract of the plant has a higher concentration of phenolics and exhibits strong antioxidant activity. These findings highlight the importance of A. macrobotrys as a medicinal plant and a potential source of antioxidants.
Article
Horticulture
Hosakatte Niranjana Murthy, Guggalada Govardhana Yadav, Sathish Shekhappa Kadapatti, Akarsha H. Pote, Ramalinga Jagali, Vidya Yarashi, Yaser Hassan Dewir
Summary: The present study investigated the nutritional composition, phytochemical composition, and antioxidant activities of Rourea minor fruits. The ripened seeds and pulp contained various components, including fat, protein, carbohydrates, ash, and fiber. Both the seeds and pulp were also rich in microelements. The study also found that the extracts from the fruits exhibited strong antioxidant activity. The findings suggest that Rourea minor fruits could be a valuable source of nutrients, microelements, and antioxidants.
Article
Horticulture
Yaser Hassan Dewir, Muhammad M. Habib, AbdulAziz A. AlQarawi, Thobayet S. Alshahrani, Ahmed Ali Alaizari, Jahangir A. Malik, Mona S. Alwahibi, Hosakatte Niranjana Murthy
Summary: This study examined the effect of arbuscular mycorrhizal fungi (AMF) on the growth and development of tissue-cultured Philodendron bipinnatifidum plantlets during the acclimatization phase. The results showed that AMF-treated plants had better growth characteristics and root development compared to non-AMF plants. These findings highlight the importance of mycorrhization in promoting vegetative growth and acclimatization of micropropagated plants.
Review
Biotechnology & Applied Microbiology
Hosakatte Niranjana Murthy, Kadanthottu Sebastian Joseph, Kee Yoeup Paek, So Young Park
Summary: In vitro plant cell and organ cultures are attractive alternatives for producing valuable specialized metabolites. Adventitious roots are often superior to cell suspension cultures for accumulating high levels of specialized metabolites. Different bioreactor systems have been investigated for cultivation of adventitious roots.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Review
Plant Sciences
Hosakatte Niranjana Murthy, Kadanthottu Sebastian Joseph, Kee Yoeup Paek, So Young Park
Summary: Plant cells and organ cultures are viable alternatives for producing specialized metabolites. Elicitation is a strategy used to enhance the accumulation of these compounds, and nanoparticles have recently been used as unique elicitors. This review summarizes the applications and usage of nanoparticles as elicitors in plant cell and organ cultures.
PLANT GROWTH REGULATION
(2023)
Review
Plant Sciences
Hosakatte Niranjana Murthy, Kadanthottu Sebastian Joseph, Jong-Eun Hahn, Han-Sol Lee, Kee Yoeup Paek, So Young Park
Summary: This review provides an update on the use of somatic embryogenesis in the production of valuable secondary metabolites, discussing the factors influencing their generation, elicitation methods, and prospective applications.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2023)
Article
Agronomy
Myeong-Jin Lim, Hosakatte Niranjana Murthy, Hyun-Young Song, Su-Young Lee, So-Young Park
Summary: This study investigated the effects of red, blue, white, and red plus blue and red, blue, and green LEDs on the in vitro regeneration of Gerbera jamesonii cv. 'Shy Pink'. The results showed that red plus blue LEDs had the greatest impact on shoot regeneration, growth, and root regeneration. Red and blue LEDs affected different parts of the plant, with blue LEDs promoting higher photosynthetic pigment content. White LEDs had a strong effect on chlorophyll fluorescence.
Article
Business
V. Mamtha, H. N. Narasimha Murthy, V. Pujith Raj, Prashantha Tejas, C. S. Puneet, Achyutha Venugopal, Sham AanMankunipoyil, C. Manjunatha
Summary: This study investigates the synergistic effect of AgNP and MgO as nanofillers in electrospun Polyurethane. The results show that the addition of MgO improves the physical properties of the nanofibers, while the addition of AgNP enhances the antibacterial activity.
CLOTHING AND TEXTILES RESEARCH JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Sathish Shekhappa Kadapatti, Hosakatte Niranjana Murthy
Summary: A reliable In vitro micropropagation method was developed in Andrographis producta through direct organogenesis, which is helpful for the multiplication, conservation, and utilization of this plant.
JOURNAL OF GENETIC ENGINEERING AND BIOTECHNOLOGY
(2022)