Poly(lactic acid) and poly(lactic-co-glycolic acid) particles as versatile carrier platforms for vaccine delivery

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

(2014) Petr O. Ilyinskii et al.   VACCINE

Targeting C-type lectin receptors with multivalent carbohydrate ligands

(2013) Bernd Lepenies et al.   ADVANCED DRUG DELIVERY REVIEWS

Targeted oral delivery of BmpB vaccine using porous PLGA microparticles coated with M cell homing peptide-coupled chitosan

(2013) Tao Jiang et al.   BIOMATERIALS

Blueprints of Signaling Interactions between Pattern Recognition Receptors: Implications for the Design of Vaccine Adjuvants

(2013) Kim Timmermans et al.   Clinical and Vaccine Immunology

Development and characterization of surface modified PLGA nanoparticles for nasal vaccine delivery: Effect of mucoadhesive coating on antigen uptake and immune adjuvant activity

(2013) Dilip Pawar et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Combination of adjuvants: the future of vaccine design

(2013) Adele Mount et al.   Expert Review of Vaccines

Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties

(2013) Vincent Pavot et al.   JOURNAL OF CONTROLLED RELEASE

Immune system targeting by biodegradable nanoparticles for cancer vaccines

(2013) Joana M. Silva et al.   JOURNAL OF CONTROLLED RELEASE

A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation

(2013) Maha Maglinao et al.   JOURNAL OF CONTROLLED RELEASE

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

(2013) A. de Titta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Potent Antigen-specific Cytotoxic T Cell Response by PLGA-nanoparticles Containing Antigen and TLR Agonist

(2013) Young-Ran Lee et al.   Immune Network

Biodegradable Particles as Vaccine Delivery Systems: Size Matters

(2012) Vijaya B. Joshi et al.   AAPS Journal

Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype

(2012) Stacey L. Demento et al.   BIOMATERIALS

Potential of NOD receptor ligands as immunomodulators in particulate vaccine carriers

(2012) Christian Wischke et al.   JOURNAL OF CONTROLLED RELEASE

PLGA-based nanoparticles: An overview of biomedical applications

(2012) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

Large intestine–targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection

(2012) Qing Zhu et al.   NATURE MEDICINE

Micro and Nanoparticle-Based Delivery Systems for Vaccine Immunotherapy: An Immunological and Materials Perspective

(2012) Jardin Leleux et al.   Advanced Healthcare Materials

Evaluation of a Diphtheria and Tetanus PLGA Microencapsulated Vaccine Formulation without Stabilizers

(2012) Wagner Quintilio et al.   Current Drug Delivery

The influence of PEG chain length and targeting moiety on antibody-mediated delivery of nanoparticle vaccines to human dendritic cells

(2011) Luis J. Cruz et al.   BIOMATERIALS

Particulate vaccines: on the quest for optimal delivery and immune response

(2011) Marie-Luce De Temmerman et al.   DRUG DISCOVERY TODAY

Soybean agglutinin coated PLA particles entrapping candidate vaccines induces enhanced primary and sustained secondary antibody response from single point immunization

(2011) Rajesh Kumar Gupta et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The long-term potential of biodegradable poly(lactideco-glycolide) microparticles as the next-generation vaccine adjuvant

(2011) Siddhartha Jain et al.   Expert Review of Vaccines

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

(2011) Rassoul Dinarvand et al.   International Journal of Nanomedicine

Alum adjuvant: some of the tricks of the oldest adjuvant

(2011) M. Kool et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Activation of Antigen-Specific T Cell-Responses by Mannan-Decorated PLGA Nanoparticles

(2011) Samar Hamdy et al.   PHARMACEUTICAL RESEARCH

New insights in mucosal vaccine development

(2011) Vincent Pavot et al.   VACCINE

Formulation and Characterization of Antigen-loaded PLGA Nanoparticles for Efficient Cross-priming of the Antigen

(2011) Young-Ran Lee et al.   Immune Network

Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells

(2010) Charlotte Primard et al.   BIOMATERIALS

Modulation of immune responses through direct activation of Toll-like receptors to T cells

(2010) G. Liu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

Lectin anchored PLGA nanoparticles for oral mucosal immunization against hepatitis B

(2010) Neeraj Mishra et al.   JOURNAL OF DRUG TARGETING

TLR9-Targeted Biodegradable Nanoparticles as Immunization Vectors Protect against West Nile Encephalitis

(2010) S. L. Demento et al.   JOURNAL OF IMMUNOLOGY

Vaccines with Aluminum-containing Adjuvants: Optimizing Vaccine Efficacy and Thermal Stability

(2010) Tanya Clapp et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Aerosolized PLA and PLGA Nanoparticles Enhance Humoral, Mucosal and Cytokine Responses to Hepatitis B Vaccine

(2010) Chandan Thomas et al.   MOLECULAR PHARMACEUTICS

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Dextran microspheres could enhance immune responses against PLGA nanospheres encapsulated with tetanus toxoid andQuillajasaponins after nasal immunization in rabbit

(2010) Maliheh Mohaghegh et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: Nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

(2010) Bram Slütter et al.   VACCINE

Enhancing Oral Vaccine Potency by Targeting Intestinal M Cells

(2010) Ali Azizi et al.   PLoS Pathogens

Nanocarriers’ entry into the cell: relevance to drug delivery

(2009) Hervé Hillaireau et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Physico-chemical characterisation of PLGA nanoparticles after freeze-drying and storage

(2009) Melisande Holzer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Regulatory T cells and Toll-like receptors: What is the missing link?

(2009) Jie Dai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Humoral and cell-mediated immune-responses after administration of a single-shot recombinant hepatitis B surface antigen vaccine formulated with cationic poly(l-lactide) microspheres

(2009) Vinay Saini et al.   JOURNAL OF DRUG TARGETING

Unleashing the therapeutic potential of NOD-like receptors

(2009) Kaoru Geddes et al.   NATURE REVIEWS DRUG DISCOVERY

Specific and non-specific phagocytosis of ligand-grafted PLGA microspheres by macrophages

(2008) Nolwenn Brandhonneur et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles

(2008) Christian Wischke et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Stabilization of Tetanus Toxoid Encapsulated in PLGA Microspheres

(2008) Wenlei Jiang et al.   MOLECULAR PHARMACEUTICS

Role of Particle Size in Phagocytosis of Polymeric Microspheres

(2008) Julie A. Champion et al.   PHARMACEUTICAL RESEARCH