In situ polymerization on biomacromolecules for nanomedicines

Synthesis of lipase polymer hybrids with retained or enhanced activity using the grafting-from strategy

(2018) Marina Kovaliov et al.   POLYMER

A simple route to highly active single-enzyme nanogels

(2018) Ana Beloqui et al.   Chemical Science

Site-Specific Insulin-Trehalose Glycopolymer Conjugate by Grafting from Strategy Improves Bioactivity

(2018) Kathryn M. Mansfield et al.   ACS Macro Letters

Nanocapsules of therapeutic proteins with enhanced stability and long blood circulation for hyperuricemia management

(2017) Xiaopei Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties

(2017) Kaimin Cai et al.   JOURNAL OF CONTROLLED RELEASE

Enzymatic bioactivity investigation of glucose oxidase modified with hydrophilic or hydrophobic polymers via in situ RAFT polymerization

(2017) Gengfang Xu et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Intracellular delivery of proteins by nanocarriers

(2017) Moumita Ray et al.   Nanomedicine

First AAV gene therapy poised for landmark approval

(2017) Eric Smalley   NATURE BIOTECHNOLOGY

Refining strategies to translate genome editing to the clinic

(2017) Tatjana I Cornu et al.   NATURE MEDICINE

Delivery technologies for genome editing

(2017) Hao Yin et al.   NATURE REVIEWS DRUG DISCOVERY

Grafting challenging monomers from proteins using aqueous ICAR ATRP under bio-relevant conditions

(2017) Devora Cohen-Karni et al.   Polymer Chemistry

Grafting-From Proteins Using Metal-Free PET–RAFT Polymerizations under Mild Visible-Light Irradiation

(2017) Bryan S. Tucker et al.   ACS Macro Letters

The Market of Biopharmaceutical Medicines: A Snapshot of a Diverse Industrial Landscape

(2017) Evelien Moorkens et al.   Frontiers in Pharmacology

History of Polymeric Gene Delivery Systems

(2017) Peng Zhang et al.   Topics in Current Chemistry

Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration

(2016) Haijun Tian et al.   ACS Nano

Bottom-Up Fabrication of Nanopatterned Polymers on DNA Origami by In Situ Atom-Transfer Radical Polymerization

(2016) Yu Tokura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy

(2016) Jin Hu et al.   BIOMATERIALS

Half-life extended biotherapeutics

(2016) Roland E. Kontermann   EXPERT OPINION ON BIOLOGICAL THERAPY

Butyrylcholinesterase nanocapsule as a long circulating bioscavenger with reduced immune response

(2016) Peng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy

(2016) Jin Hu et al.   JOURNAL OF CONTROLLED RELEASE

PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs

(2016) Peter L. Turecek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Phosphorylcholine polymer nanocapsules prolong the circulation time and reduce the immunogenicity of therapeutic proteins

(2016) Sheng Liang et al.   Nano Research

Prolonging the plasma circulation of proteins by nano-encapsulation with phosphorylcholine-based polymer

(2016) Linlin Zhang et al.   Nano Research

In situ fabrication of PHEMA–BSA core–corona biohybrid particles

(2016) Jin-Tao Wang et al.   Journal of Materials Chemistry B

Specific Elimination of Latently HIV-1 Infected Cells Using HIV-1 Protease-Sensitive Toxin Nanocapsules

(2016) Jing Wen et al.   PLoS One

Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control

(2015) Suwei Zhu et al.   ADVANCED MATERIALS

Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention

(2015) Jin Hu et al.   BIOMATERIALS

Robust enzyme–silica composites made from enzyme nanocapsules

(2015) Jie Li et al.   CHEMICAL COMMUNICATIONS

An overview of FDA-approved biologics medicines

(2015) Michael S. Kinch   DRUG DISCOVERY TODAY

Well-Defined Protein/Peptide–Polymer Conjugates by Aqueous Cu-LRP: Synthesis and Controlled Self-Assembly

(2015) Qiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Versatile Protein Nanogels Prepared by In Situ Polymerization

(2015) Yanqi Ye et al.   MACROMOLECULAR CHEMISTRY AND PHYSICS

Grafting from Small Interfering Ribonucleic Acid (siRNA) as an Alternative Synthesis Route to siRNA–Polymer Conjugates

(2015) En-Wei Lin et al.   MACROMOLECULES

Innovation in biologic new molecular entities: 1986–2014

(2015) Kathleen L. Miller et al.   NATURE REVIEWS DRUG DISCOVERY

Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

(2015) Peng Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein ROMP: Aqueous Graft-from Ring-Opening Metathesis Polymerization

(2015) Sergey A. Isarov et al.   ACS Macro Letters

Protein–polymer therapeutics: a macromolecular perspective

(2015) Yuzhou Wu et al.   Biomaterials Science

Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs

(2015) Ming Yan et al.   PLoS One

Gold-Nanocrystal-Enhanced Bioluminescent Nanocapsules

(2014) Juanjuan Du et al.   ACS Nano

Efficient Delivery of Therapeutic miRNA Nanocapsules for Tumor Suppression

(2014) Chaoyong Liu et al.   ADVANCED MATERIALS

Solid-Phase Incorporation of an ATRP Initiator for Polymer-DNA Biohybrids

(2014) Saadyah E. Averick et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible light induced fast synthesis of protein–polymer conjugates: controllable polymerization and protein activity

(2014) Xin Li et al.   CHEMICAL COMMUNICATIONS

Cocoon-Like Self-Degradable DNA Nanoclew for Anticancer Drug Delivery

(2014) Wujin Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clickable Protein Nanocapsules for Targeted Delivery of Recombinant p53 Protein

(2014) Muxun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced structural stability of adenovirus nanocapsule

(2014) Ding Weng et al.   Progress in Natural Science-Materials International

Glucose-Responsive Microgels Integrated with Enzyme Nanocapsules for Closed-Loop Insulin Delivery

(2013) Zhen Gu et al.   ACS Nano

Construction of Robust Enzyme Nanocapsules for Effective Organophosphate Decontamination, Detoxification, and Protection

(2013) Wei Wei et al.   ADVANCED MATERIALS

Synthesis of Functionalizable and Degradable Polymers by Ring-Opening Metathesis Polymerization

(2013) Joshua M. Fishman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Protein conjugation with genetically encoded unnatural amino acids

(2013) Chan Hyuk Kim et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein–polymer hybrids: Conducting ARGET ATRP from a genetically encoded cleavable ATRP initiator

(2013) Saadyah E. Averick et al.   EUROPEAN POLYMER JOURNAL

Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein

(2013) Yizhi Qi et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Degradable polymeric nanocapsule for efficient intracellular delivery of a high molecular weight tumor-selective protein complex

(2013) Muxun Zhao et al.   Nano Today

Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication

(2013) Yang Liu et al.   Nature Nanotechnology

Growing polymers from peptides and proteins: a biomedical perspective

(2013) Yizhi Qi et al.   Polymer Chemistry

Retargeting Vesicular Stomatitis Virus Glycoprotein Pseudotyped Lentiviral Vectors with Enhanced Stability by In Situ Synthesized Polymer Shell

(2013) Min Liang et al.   Human Gene Therapy Methods

Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor

(2012) Anuradha Biswas et al.   BIOMATERIALS

Single siRNA Nanocapsules for Enhanced RNAi Delivery

(2012) Ming Yan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atom Transfer Radical Polymerization (ATRP): Current Status and Future Perspectives

(2012) Krzysztof Matyjaszewski   MACROMOLECULES

Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading

(2012) Janice Lucon et al.   Nature Chemistry

Endoprotease-Mediated Intracellular Protein Delivery Using Nanocapsules

(2011) Anuradha Biswas et al.   ACS Nano

Uniform polymer–protein conjugate by aqueous AGET ATRP using protein as a macroinitiator

(2011) Binbin Zhu et al.   Acta Biomaterialia

Controlled Protein Delivery Based on Enzyme-Responsive Nanocapsules

(2011) Jing Wen et al.   ADVANCED MATERIALS

Protein−Polymer Nanoparticles for Nonviral Gene Delivery

(2011) Jianjun Zhang et al.   BIOMACROMOLECULES

Redox-responsive nanocapsules for intracellular protein delivery

(2011) Muxun Zhao et al.   BIOMATERIALS

Tailoring nanocarriers for intracellular protein delivery

(2011) Zhen Gu et al.   CHEMICAL SOCIETY REVIEWS

Synthetic Nanocarriers for Intracellular Protein Delivery

(2011) Juanjuan Du et al.   CURRENT DRUG METABOLISM

Introduction to current and future protein therapeutics: A protein engineering perspective

(2011) Paul J. Carter   EXPERIMENTAL CELL RESEARCH

Functional Virus-Based Polymer–Protein Nanoparticles by Atom Transfer Radical Polymerization

(2011) Jonathan K. Pokorski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermoresponsive Block Copolymer-Protein Conjugates Prepared by Grafting-from via RAFT Polymerization

(2011) Ming Li et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Post-production protein stability: trouble beyond the cell factory

(2011) Esther Vazquez et al.   Microbial Cell Factories

Synthesis of protein nano-conjugates for cancer therapy

(2011) Jianjun Zhang et al.   Nano Research

Pharmacogenetics and the immunogenicity of protein therapeutics

(2011) Chen Yanover et al.   NATURE BIOTECHNOLOGY

Responsive hybrid block co-polymer conjugates of proteins–controlled architecture to modulate substrate specificity and solution behaviour

(2011) Gökçen Yaşayan et al.   Polymer Chemistry

Block copolymer conjugates prepared by sequentially grafting from proteins via RAFT

(2011) Hongmei Li et al.   Polymer Chemistry

Covalently incorporated protein–nanogels using AGET ATRP in an inverse miniemulsion

(2011) Saadyah E. Averick et al.   Polymer Chemistry

ATRP under Biologically Relevant Conditions: Grafting from a Protein

(2011) Saadyah Averick et al.   ACS Macro Letters

Adding New Chemistries to the Genetic Code

(2010) Chang C. Liu et al.   Annual Review of Biochemistry

In Situ Growth of Side-Chain PEG Polymers from Functionalized Human Growth Hormone—A New Technique for Preparation of Enhanced Protein−Polymer Conjugates

(2010) Johannes Pall Magnusson et al.   BIOCONJUGATE CHEMISTRY

Probing protease activity by single-fluorescent-protein nanocapsules

(2010) Zhen Gu et al.   CHEMICAL COMMUNICATIONS

A simple methodology for the synthesis of heterotelechelic protein-polymer-biomolecule conjugates

(2010) Jingquan Liu et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Quantum-Dot-Decorated Robust Transductable Bioluminescent Nanocapsules

(2010) Juanjuan Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genetically Encoded Initiator for Polymer Growth from Proteins

(2010) Jennifer C. Peeler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

'Green' reversible addition-fragmentation chain-transfer (RAFT) polymerization

(2010) Mona Semsarilar et al.   Nature Chemistry

In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation

(2010) W. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface-Initiated Activators Generated by Electron Transfer for Atom Transfer Radical Polymerization in Detection of DNA Point Mutation

(2009) Hong Qian et al.   ANALYTICAL CHEMISTRY

Apoptin, a tumor-selective killer

(2009) Marek Los et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lipase Nanogel Catalyzed Transesterification in Anhydrous Dimethyl Sulfoxide

(2009) Jun Ge et al.   BIOMACROMOLECULES

Protein Nanocapsule Weaved with Enzymatically Degradable Polymeric Network

(2009) Zhen Gu et al.   NANO LETTERS

A novel intracellular protein delivery platform based on single-protein nanocapsules

(2009) Ming Yan et al.   Nature Nanotechnology

In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics

(2009) W. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Fundamentals of Enzyme Nanogels

(2008) Jun Ge et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Temperature-Regulated Activity of Responsive Polymer−Protein Conjugates Prepared by Grafting-from via RAFT Polymerization

(2008) Priyadarsi De et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY