Review
Biochemistry & Molecular Biology
Claudia Molinaro, Mariangela Scalise, Isabella Leo, Luca Salerno, Jolanda Sabatino, Nadia Salerno, Salvatore De Rosa, Daniele Torella, Eleonora Cianflone, Fabiola Marino
Summary: There is growing interest in understanding the role of the immune system, particularly macrophages, in the response to cardiac injury and regeneration. Deciphering these mechanisms could lead to novel therapeutic strategies for cardiac regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov
Summary: Chronic obstructive pulmonary disease (COPD) is a common disease characterized by progressive airflow limitation due to chronic inflammation in the bronchi. The mechanisms of the innate immune system play a role in the pathogenesis of COPD, leading to chronic inflammation and lung tissue damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Beryl N. Arinda, Yacoub A. Innabi, Juris A. Grasis, Nestor J. Oviedo
Summary: This article explores the additional roles of immune cells and their interactions with stem cells in regulating tissue repair and regeneration.
Review
Biochemistry & Molecular Biology
Luana Tripodi, Chiara Villa, Davide Molinaro, Yvan Torrente, Andrea Farini
Summary: The interaction between the immune system and skeletal muscle plays a crucial role in inflammatory muscle diseases and dystrophic conditions, affecting muscle regeneration and pathogenesis.
Article
Biochemistry & Molecular Biology
Sachin Shukla, Won Kyung Cho, Elsayed Elbasiony, Rohan B. Singh, Sharad K. Mittal, Sunil K. Chauhan
Summary: Regulation of innate inflammation is crucial for tissue homeostasis and barrier function, especially in the skin and cornea. IL36 gamma is the primary agonist expressed by corneal epithelium and is upregulated after corneal injury. Blocking IL36 gamma promotes rapid re-epithelialization and suppresses tissue inflammation.
Review
Biochemistry & Molecular Biology
Guzel Rafikova, Svetlana Piatnitskaia, Elena Shapovalova, Svyatoslav Chugunov, Victor Kireev, Daria Ialiukhova, Azat Bilyalov, Valentin Pavlov, Julia Kzhyshkowska
Summary: The immuno-compatibility of ceramic implants, which depends on the interaction with immune cells, is still insufficiently understood and requires intensive experimental research. This review summarizes the state of the art in ceramic implants, including their mechanical properties, chemical modifications, surface structures, and shapes. The gaps in knowledge are identified, and the possibilities for further research using advanced quantitative technologies are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Yu Zhen, Wentao Shu, Xintong Hou, Yinan Wang
Summary: This study focuses on the role of innate immune cells in visceral adipose tissue (VAT) in maintaining tissue homeostasis and responding to changes induced by obesity, leading to chronic inflammation and metabolic diseases. The review emphasizes the importance of understanding the quantitative and functional changes in immune cells in the context of obesity-induced metabolic dysfunction, highlighting the need to consider complex interactive networks among different cell populations in the development of biotherapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Lena M. Ernst, Eudald Casals, Paola Italiani, Diana Boraschi, Victor Puntes
Summary: The immune system plays a crucial role in maintaining the body's functional integrity by recognizing and destroying foreign agents and abnormal cells. Nanoparticles can interact with the immune system in complex ways, potentially leading to different immune responses.
Review
Pharmacology & Pharmacy
Mireia Medrano-Bosch, Alazne Moreno-Lanceta, Pedro Melgar-Lesmes
Summary: Nanoparticles, with their tunable physical, chemical, and biological characteristics, have gained attention in technological advances. Challenges remain in the administration of nanoparticles to living beings due to rapid detection and clearance by the mononuclear phagocytic system. Current research is focused on designing nanoparticles for specific targeting of macrophages in diseased tissues.
Review
Immunology
Mingyue Duan, Xiaoguai Liu, Ying Yang, Yanmin Zhang, Rongqian Wu, Yi Lv, Hong Lei
Summary: This study focused on the immune inflammation and regulation with the involvement of innate and adaptive immune cells in the progression of acute liver injury in children. It also discussed the immunological perspective of hepatic involvement with SARS-CoV-2 infection and acute severe hepatitis of unknown origin in children. Furthermore, the study highlighted the molecular crosstalk between immune cells and the role of damage-associated molecular patterns (DAMPs) in liver injury.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuhuai Xie, Yuanyuan Wei
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in regulating antimicrobial responses in the host innate immune system, impacting immune cell development and function, inflammatory processes, and antiviral mechanisms through interactions with DNA, RNA, or proteins. Dysregulation of lncRNA function is linked to various human non-infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Melissa Prat, Kimberley Coulson, Clement Blot, Godefroy Jacquemin, Mathilde Romano, Marie-Laure Renoud, Mohamad AlaEddine, Augustin Le Naour, Helene Authier, Mouna Chirine Rahabi, Khaddouj Benmoussa, Marie Salon, Melissa Parny, Jean-Pierre Delord, Gwenael Ferron, Lise Lefevre, Bettina Couderc, Agnes Coste
Summary: In this study, it was found that activation of PPARγ in treated small peritoneal macrophages can inhibit ovarian adenocarcinoma growth, regulate the proportion of immune cells, and attenuate the immunosuppressive properties of tumor-associated macrophages.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Nyemkuna Fortingo, Samuel Melnyk, Sarah H. Sutton, Mitchell A. Watsky, Wendy B. Bollag
Summary: Inflammation plays a complex role in corneal wound healing. While acute inflammation is necessary to prevent infection, chronic or excessive inflammation can delay healing and worsen outcomes. Reductions in severe or chronic inflammation lead to better corneal clarity, thickness, and healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Annica Proehl, Milijana Batinic, Said Alkildani, Michael Hahn, Milena Radenkovic, Stevo Najman, Ole Jung, Mike Barbeck
Summary: The study showed that the new hyaluronate containing bone substitute material has comparable bone healing capacity to the control xenogeneic BSM, with no significant differences in bone formation or inflammatory tissue responses. Both materials were fully biocompatible and allowed for gradual osteoconductive bone regeneration without differences in tissue reactions compared to a sham operation group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jacqueline A. Larouche, Emily C. Wallace, Bonnie D. Spence, Eric Buras, Carlos A. Aguilar
Summary: A study on a mouse model of Volumetric muscle loss (VML) reveals that the interaction between fibrotic and inflammatory macrophages and mesenchymal-derived cells plays a crucial role in the abnormal regeneration process. Interventions targeting this cellular crosstalk can enhance regeneration, reduce inflammation, and fibrosis.
Review
Anatomy & Morphology
Kimberly M. Morelli, Bradley R. Martin, Fatima H. Charakla, Anel Durmisevic, Gordon L. Warren
Article
Sport Sciences
Kyle J. Brandenberger, Gordon L. Warren, Christopher P. Ingalls, Jeff S. Otis, J. Andrew Doyle
Summary: The study showed that a 1-hour downhill run significantly injured the knee extensors while the elbow flexor muscles remained uninjured but their strength was impaired. Data suggests that muscle injury can lead to prolonged strength deficits in muscles distant from the injury.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Sport Sciences
Cory W. Baumann, Gordon L. Warren, Dawn A. Lowe
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2020)
Article
Orthopedics
L-C Tsai, E. S. Cooper, K. M. Hetzendorfer, G. L. Warren, Y-H Chang, N. J. Willett
OSTEOARTHRITIS AND CARTILAGE
(2019)
Article
Engineering, Biomedical
Liang-Ching Tsai, Zuowei Zhao, Steven M. Fridenmaker, Gordon L. Warren
ISOKINETICS AND EXERCISE SCIENCE
(2020)
Article
Cardiac & Cardiovascular Systems
Kyle J. Brandenberger, Rachel Culbreth, Samuel Shan, Douglas S. Gardenhire, Gordon L. Warren
Article
Endocrinology & Metabolism
Jerid W. Robinson, Nicholas C. Blixt, Andrew Norton, Kim C. Mansky, Zhou Ye, Conrado Aparicio, Brandon M. Wagner, Andrew M. Benton, Gordon L. Warren, Sundeep Khosla, Dana Gaddy, Larry J. Suva, Lincoln R. Potter
Article
Endocrinology & Metabolism
Christine A. Cabelka, Cory W. Baumann, Angus Lindsay, Andrew Norton, Nick C. Blixt, Gengyun Le, Gordon L. Warren, Kim C. Mansky, Susan A. Novotny, Dawn A. Lowe
Summary: The tissue-selective effects of Bazedoxifene (BZA) on musculoskeletal system in Ovariectomized (OVX) female mice indicate that BZA may act as an estrogen receptor agonist in skeletal muscle, as it has been seen in bone, providing minor benefits to the musculoskeletal system.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Joyceann P. Trost, Mo Chen, Molly M. Stark, James S. Hodges, Sara Richter, Angus Lindsay, Gordon L. Warren, Dawn A. Lowe, Teresa J. Kimberley
Summary: The protocol combining voluntary and evoked contractions is a safe, feasible, reliable, and valid method to measure strength and excitability of wrist extensors in males with DMD, showing excellent reliability and discriminant validity between DMD patients and controls.
Article
Biotechnology & Applied Microbiology
Cheryl L. San Emeterio, Lauren A. Hymel, Thomas C. Turner, Molly E. Ogle, Emily G. Pendleton, William Y. York, Claire E. Olingy, Alan Y. Liu, Hong Seo Lim, Todd A. Sulchek, Gordon L. Warren, Luke J. Mortensen, Peng Qiu, Young C. Jang, Nick J. Willett, Edward A. Botchwey
Summary: Volumetric muscle loss (VML) is a significant clinical challenge after extremity trauma, and an immunomodulatory biomaterial therapy shows promise in addressing this issue. Modulating S1P receptor signaling can enhance muscle stem cell abundance and myofiber diameter, aiding in regeneration following VML injury.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Physiology
Cory W. Baumann, Angus Lindsay, Sylvia R. Sidky, James M. Ervasti, Gordon L. Warren, Dawn A. Lowe
Summary: Our study found that maintenance of plasmalemmal excitability after eccentric contractions depends on intact and functional dystrophin glycoprotein complex (DGC) rather than solely dystrophin expression. Loss of torque after eccentric contractions was greater in dystrophic mouse lines compared to wild-type mice, showing the significant role of DGC in maintaining plasmalemmal excitability. Additionally, deficiency of the DGC protein beta-sarcoglycan was found to be equally disruptive to plasmalemmal excitability as dystrophin deficiency.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Orthopedics
Liang-Ching Tsai, Christopher M. Jeanfreau, Katherine A. Hamblin, John M. Popovich, Mark A. Lyle, Daniel F. Cottmeyer, Gordon L. Warren
Summary: This meta-analysis examined the factors influencing quadriceps weakness after ACL reconstruction. The results showed that factors such as time post-surgery, graft type, gender, geographic location, and isokinetic speed can affect the magnitude of quadriceps weakness. Patients with patellar tendon autografts demonstrated greater between-limb asymmetry in quadriceps strength, while female strength deficits were underestimated to a greater extent.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Physiology
Gengyun Le, Cory W. Baumann, Gordon L. Warren, Dawn A. Lowe
Summary: This study developed a novel method to measure muscle strength in female mice, and found that estradiol enhances posttetanic twitch potentiation (PTP) through the G-protein estrogen receptor (GPER) signaling rather than ERa or ERss signaling pathways. These findings indicate the importance of GPER in mediating the effects of estradiol on muscle strength in female mice.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Family Studies
Susan J. Kelley, Deborah M. Whitley, Shannon R. Escarra, Rowena Zheng, Eva M. Horne, Gordon L. Warren
Summary: The meta-analysis of six studies suggests that custodial grandparents raising grandchildren are more likely to experience adverse mental health outcomes compared to their non-parenting counterparts. This finding adds to the existing evidence of their emotional vulnerability and calls for further research in this area.
MARRIAGE AND FAMILY REVIEW
(2021)
Review
Gerontology
Fayron Epps, Helen To, Tao Tony Liu, Asmita Karanjit, Gordon Warren
Summary: Increased demands associated with caregiving may have negative impacts on the physical and mental health of caregivers, while exercise training has been shown to improve the health of caregivers for persons living with chronic illnesses.
JOURNAL OF APPLIED GERONTOLOGY
(2021)
