Review
Clinical Neurology
Florian Holtbernd, N. Jon Shah
Summary: Functional imaging studies consistently show altered functional connectivity in the cerebellum and cerebello-thalamico-cortical circuitry. Structural imaging studies are less consistent, with no clear evidence for cerebellar neurodegeneration, but diffusion tensor imaging robustly points toward microstructural cerebellar changes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neuroimaging
Donato Colella, Massimiliano Passaretti, Viviana Frantellizzi, Maria Silvia De Feo, Antonio Cannavacciuolo, Luca Angelini, Daniele Birreci, Davide Costa, Giulia Paparella, Andrea Guerra, Giuseppe De Vincentis, Alfredo Berardelli, Matteo Bologna
Summary: This research investigated the correlation between basal ganglia dopaminergic neurotransmission and finger movements abnormalities in patients with essential tremor (ET) and Parkinson's disease (PD). The findings showed that ET patients had slower finger tapping and normal radiotracer uptake levels in the striatum, while PD patients had reduced uptake. There was also a connection between radiotracer uptake and movement velocity during finger tapping in both patient groups.
NEUROIMAGE-CLINICAL
(2023)
Article
Neuroimaging
Patrick Bedard, Pattamon Panyakaew, Hyun-Joo Cho, Mark Hallett, Silvina G. Horovitz
Summary: This study aimed to understand the differential pathophysiology of essential tremor and dystonic tremor. The results showed altered functional connectivity in the cerebellum for essential tremor patients, higher fractional anisotropy in the middle cerebellar peduncle for dystonic tremor patients, and reduced mean diffusivity in the cerebellum for both tremor groups. The findings suggest that the cerebellum is affected differently in both essential tremor and dystonic tremor.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Luca Angelini, Giulia Paparella, Alessandro De Biase, Annalisa Maraone, Matteo Panfili, Isabella Berardelli, Antonio Cannavacciuolo, Antonella Di Vita, Roberta Margiotta, Giovanni Fabbrini, Alfredo Berardelli, Matteo Bologna
Summary: This study investigated the progression of Essential Tremor (ET) manifestations through clinical and neurophysiological evaluation. The results showed that ET progression is characterized by the spread of tremor in multiple body segments and the emergence of soft signs. Female sex, absence of family history, and rest tremor at baseline were identified as predictive factors of worse disease progression.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Gabriela S. Gilmour, Davide Martino, Karen Hunka, Pia Lawrence, Zelma H. T. Kiss, Veronica Bruno
Summary: In this study, it was found that patients with ET-plus had similar tremor outcomes after VIM DBS compared to those with ET, without the development of new neurological issues. This suggests that patients with ET-plus can still be considered good candidates for VIM DBS treatment of tremor.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Takashi Tsuboi, Joshua K. Wong, Robert S. Eisinger, Lela Okromelidze, Mathew R. Burns, Adolfo Ramirez-Zamora, Leonardo Almeida, Aparna Wagle Shukla, Kelly D. Foote, Michael S. Okun, Sanjeet S. Grewal, Erik H. Middlebrooks
Summary: The optimal targets for deep brain stimulation in essential tremor and dystonic tremor remain unknown. This study suggests that DBS targeting the ventral intermediate nucleus/ventralis oralis posterior nucleus border and ventral intermediate nucleus region may be a reasonable treatment option for medication-refractory dystonic tremor and essential tremor patients. Our findings highlight the involvement of cerebello-thalamo-cortical and basal ganglia-thalamo-cortical networks in the pathophysiology of dystonic tremor.
Article
Clinical Neurology
Jiaxin Peng, Nannan Li, Junying Li, Liren Duan, Chaolan Chen, Yan Zeng, Jing Xi, Yi Jiang, Rong Peng
Summary: This study reclassified and compared the characteristics of ET and ET-plus patients in a large Chinese tremor cohort. The results showed that ET-plus patients were older, had longer disease durations, worse tremor manifestations, and more distinct non-motor symptoms. Certain additional soft signs of ET-plus were associated with tremor severity or worse quality of life.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Ming-Kai Pan, Sheng-Han Kuo
Summary: This article reviews the clinical features, pathophysiology, and various pathogenic mechanisms of essential tremor, highlighting the role of the cerebellum and the multiple abnormal brain circuitry that can contribute to action tremor.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Alessia Sarica, Andrea Quattrone, Marianna Crasa, Rita Nistico, Maria Grazia Vaccaro, Maria Giovanna Bianco, Vera Gramigna, Marida De Maria, Basilio Vescio, Federico Rocca, Aldo Quattrone
Summary: The study found that essential tremor (ET) and resting tremor (rET) are different tremor syndromes with mild cerebellar gray matter involvement in both. In rET patients, the left Crus II may play a crucial role in modulating brainstem excitability.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Arwa Rekik, Amina Nasri, Saloua Mrabet, Alya Gharbi, Amira Souissi, Amina Gargouri, Imen Kacem, Riadh Gouider
Summary: Mid-ET patients show greater cognitive dysfunction, depression, sleep disturbances, higher proportion of late-onset ET, and more extrapyramidal signs, indicating a greater cerebellar dysfunction.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Dongning Su, Fangzhao Zhang, Zhu Liu, Shuo Yang, Ying Wang, Huizi Ma, Brad Manor, Jeffrey M. Hausdorff, Lewis A. Lipsitz, Hua Pan, Tao Feng, Junhong Zhou
Summary: The study investigated the multiscale dynamics of hand tremor in ET and PT patients, revealing lower complexity in ET compared to PT and the potential of complexity metric in distinguishing between the two conditions. Hand tremor complexity was found to be associated with disease duration and severity, serving as a promising diagnostic marker for ET and PT differentiation.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Jos S. Becktepe, Johannes Busse, Ulf Jensen-Kondering, Inken Toedt, Stephan Wolff, Kirsten E. Zeuner, Daniela Berg, Oliver Granert, Guenther Deuschl
Summary: The study found a significant positive correlation between white matter hyperintensity (WMH) volume and tremor severity, as well as a significant negative correlation with the mean accelerometric tremor frequency. The total WMH volume predicted tremor severity, while age and disease duration were not significant in our multiple linear regression model.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Xupo Xing, Ningdi Luo, Shun Li, Liche Zhou, Chengli Song, Jun Liu
Summary: This study evaluated seven predictive models using machine learning algorithms to differentiate between Parkinson's disease and essential tremor. The results showed that random forest and extreme gradient boosting models had the best predictive ability. The analysis also revealed that the dominant frequency and average amplitude of surface electromyogram signals from flexors, as well as resting and winging postures, had the greatest impact on the diagnosis of Parkinson's disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
S. Sharifi, F. Luft, S. Potgieter, T. Heida, W. Mugge, A. C. Schouten, L. J. Bour, A. F. van Rootselaar
Summary: The study aimed to clarify the role of the motor cortex in tremor generation in essential tremor (ET) and familial cortical myoclonic tremor with epilepsy (FCMTE). The results showed that the majority of ET patients lacked a linear cortical drive, with weaker ascending coupling in ET compared to healthy controls around 5-6 Hz.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Sebastian Franthal, Michael Khalil, Daniela Kern, Lukas Gattermeyer, Arabella Buchmann, Petra Katschnig-Winter, Mariella Koegl, Rina Demjaha, Cansu Tafrali, Edith Hofer, Reinhold Schmidt, Petra Schwingenschuh
Summary: This study suggests that neurodegeneration may play a role in the pathophysiology of essential tremor and may occur at an early disease stage.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Emanuela Formaggio, Michele Tonellato, Angelo Antonini, Leonora Castiglia, Laura Gallo, Paolo Manganotti, Stefano Masiero, Alessandra Del Felice
Summary: This study aims to explore the pathophysiological mechanisms of Parkinson disease (PD) by examining changes in EEG rhythms after transcranial magnetic stimulation (TMS). The study found that TMS can temporarily normalize brain oscillations in PD patients, providing a theoretical basis for the development of practical, portable techniques to treat PD symptoms.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
An Vo, Katharina A. Schindlbeck, Nha Nguyen, Andrea Rommal, Phoebe G. Spetsieris, Chris C. Tang, Yoon Young Choi, Martin Niethammer, Vijay Dhawan, David Eidelberg
Summary: Functional imaging is widely used to identify disease-specific networks in neurodegenerative disorders. In Parkinson's disease, network assortativity increases over time, with high assortativity associated with clinically aggressive genetic variants and low assortativity associated with genes related to slow progression.
Review
Clinical Neurology
Andrew Lees, Eduardo Tolosa, Fabrizio Stocchi, Joaquim J. Ferreira, Olivier Rascol, Angelo Antonini, Werner Poewe
Summary: There is a resurgence of levodopa as the initial treatment for Parkinson's disease, while the addition of adjuvant treatments is an established strategy to reduce motor complications. Improving levodopa delivery to the brain and combining agents earlier in the disease course can leverage the full potential of this strategy.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Marta Campagnolo, Luca Weis, Carmelo Fogliano, Valeria Cianci, Michela Garon, Eleonora Fiorenzato, Miryam Carecchio, Florinda Ferreri, Patrizia Bisiacchi, Angelo Antonini, Roberta Biundo
Summary: The International Parkinson's and Movement Disorder Society (MDS) criteria has expanded the clinical spectrum of progressive supranuclear palsy (PSP) and established phenotypic characterization based on the predominant manifestation at onset. This study aimed to describe the clinical/cognitive and imaging features of a monocentric cohort of PSP patients, highlighting different patterns of functional disability according to the assigned phenotype. The findings support the concept of discrete patterns of Tau pathology within the PSP spectrum and emphasize the importance of tailored approaches in terms of follow-up and treatment.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Pablo Martinez-Martin, Matej Skorvanek, Tove Henriksen, Susanna Lindvall, Josefa Domingos, Ali Alobaidi, Prasanna L. L. Kandukuri, Vivek S. S. Chaudhari, Apeksha B. B. Patel, Juan Carlos Parra, James Pike, Angelo Antonini
Summary: This study examines the impact of advanced Parkinson's disease (APD) on caregiver burden, quality of life (QoL), and health status. The results show that caregivers of people with APD experience a greater burden, are less satisfied with treatment, and spend more time caregiving.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aron Emmi, Aleksandar Tushevski, Alessandro Sinigaglia, Silvia Barbon, Michele Sandre, Elena Stocco, Veronica Macchi, Angelo Antonini, Luisa Barzon, Andrea Porzionato, Raffaele De Caro
Summary: Angiotensin-converting enzyme 2 receptor (ACE2R) is a transmembrane protein that plays a key role in blood pressure regulation. It has gained attention for its involvement in the pathogenesis of COVID-19. This study investigated the expression of ACE2R and TMPRSS2 in the brainstem and found that they are expressed in neuronal and glial cells, particularly in specific nuclei. These findings help to understand the neurological manifestations of COVID-19.
ACS CHEMICAL NEUROSCIENCE
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Stefanie T. Jost, Agni Konitsioti, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Anna Sauerbier, Maria Gabriela dos Santos Ghilardi, Franz Rosenkranz, Lena Strobel, Alexandra Gronostay, Michael T. Barbe, Julian Evans, Veerle Visser-Vandewalle, Christopher Nimsky, Gereon R. Fink, Monty Silverdale, Rubens G. Cury, Erich T. Fonoff, Angelo Antonini, K. Ray Chaudhuri, Lars Timmermann, Pablo Martinez-Martin, Haidar S. Dafsari
Summary: This study suggests that patients with 'postural instability and gait difficulty' (PIGD) may experience more beneficial non-motor effects compared to patients with 'tremor-dominant' symptoms undergoing deep brain stimulation (DBS) for Parkinson's disease (PD). These differences in clinical efficacy on non-motor aspects should be taken into consideration when advising and monitoring PD patients undergoing DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Chemistry, Analytical
Mariana H. G. Monje, Sylvie Grosjean, Martin Srp, Laura Antunes, Raquel Bouca-Machado, Ricardo Cacho, Sergio Dominguez, John Inocentes, Timothy Lynch, Argyri Tsakanika, Dimitrios Fotiadis, George Rigas, Evzen Ruzicka, Joaquim Ferreira, Angelo Antonini, Norberto Malpica, Tiago Mestre, Alvaro Sanchez-Ferro
Summary: The healthcare model is shifting towards integrated care approaches that involve patients more closely. The iCARE-PD project aims to develop a technology-enabled, home-based, and community-centered integrated care paradigm to address this need. The project's central focus is the codesign process of the care model, with active patient participation in designing and iteratively evaluating sensor-based technological solutions. The results show the usefulness of this approach in testing usability and acceptability, as well as incorporating patients' feedback into the development.
Article
Biotechnology & Applied Microbiology
Jasmin Del Vecchio Del Vecchio, Ibrahem Hanafi, Nicolo Gabriele Pozzi, Philipp Capetian, Ioannis U. Isaias, Stefan Haufe, Chiara Palmisano
Summary: Low-frequency oscillations in the pallidal local field potentials (LFPs) can be used as a physiomarker for dystonia and personalized adaptive deep brain stimulation. However, head tremor can cause movement artifacts in the LFP signals, which affects the reliability of low-frequency oscillations as biomarkers. This study investigated the pallidal LFPs in dystonia patients and used regression analysis to identify and remove tremor-related artifacts, with the inertial measurement unit (IMU) regression showing better results than electromyographic signal (EMG) regression in artifact removal.
BIOENGINEERING-BASEL
(2023)
Review
Pharmacology & Pharmacy
Marta Campagnolo, Aron Emmi, Roberta Biundo, Eleonora Fiorenzato, Lucia Batzu, K. Ray Chaudhuri, Angelo Antonini
Summary: Behavioural symptoms in Parkinson's disease, including depression, anxiety, impulse control disorders, hallucinations, psychosis, and cognitive dysfunction, are often overlooked and not adequately addressed in many patients. Current literature suggests refraining from using dopamine agonists without considering their potential benefits on motor complications.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Clinical Neurology
Andrea Guerra, Valentina D'Onofrio, Florinda Ferreri, Matteo Bologna, Angelo Antonini
Summary: Although clinician-based assessment is the gold standard for quantifying motor impairment in Parkinson's disease, there are limitations such as variability and approximation. Objective motion analyses can complement clinical assessment and provide more accurate evaluations of motor symptoms and complications in PD.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Clinical Neurology
Alessandro Padovani, Angelo Antonini, Paolo Barone, Giuseppe Bellelli, Andrea Fagiolini, Luigi Ferini Strambi, Sandro Sorbi, Fabrizio Stocchi
Summary: This Delphi study aims to reach a shared point of view among Italian specialists on depression in Alzheimer's disease (AD). Consensus was achieved in most cases (86%), with 80% of statements receiving positive consensus and 6% receiving negative consensus. The study also highlights the strong link between depression and AD, as well as specific features of depression in AD compared to major depressive disorder (MDD).
NEUROLOGICAL SCIENCES
(2023)
Article
Neuroimaging
Phoebe G. Spetsieris, David Eidelberg
Summary: Notable progress has been made in the study of neurodegenerative diseases using reduction techniques such as principal component analysis (PCA) and sparse inverse covariance estimation (SICE) in positron emission tomography (PET) data. In a recent study on Parkinson's disease (PD) patients, SICE combined with PCA was used to optimize maps of functional metabolic connectivity and identify key regional hubs and their connections in the brain. This approach revealed a core subnetwork that remained consistent across PD patients and could serve as a target for disease modification.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Aron Emmi, Michele Sandre, Francesco Paolo Russo, Giulia Tombesi, Federica Garri, Marta Campagnolo, Miryam Carecchio, Roberta Biundo, Gaya Spolverato, Veronica Macchi, Edoardo Savarino, Fabio Farinati, Piero Parchi, Andrea Porzionato, Luigi Bubacco, Raffaele De Caro, Gabor G. Kovacs, Angelo Antonini
Summary: This study investigated the alterations of alpha-synuclein and glial responses in duodenum biopsies of Parkinson's disease (PD) patients. The findings provide evidence of synuclein pathology and gliosis in the duodenum of PD patients, including early cases, suggesting the important role of the gut in PD pathogenesis.
MOVEMENT DISORDERS
(2023)
