Essential tremor: Clinical perspectives and pathophysiology

Increased Climbing Fiber Lateral Crossings on Purkinje Cell Dendrites in the Cerebellar Hemisphere in Essential Tremor

(2021) Yueh‐Chi Wu et al.   MOVEMENT DISORDERS

Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence

(2021) Sebastian R. Schreglmann et al.   Nature Communications

Essential Tremor versus “ET-plus”: A Detailed Postmortem Study of Cerebellar Pathology

(2021) John T. Gionco et al.   CEREBELLUM

Directionality of corticomuscular coupling in essential tremor and cortical myoclonic tremor

(2021) S. Sharifi et al.   CLINICAL NEUROPHYSIOLOGY

A Phase 2 Proof‐of‐Concept, Randomized, Placebo‐Controlled Trial of CX ‐8998 in Essential Tremor

(2021) Spyros Papapetropoulos et al.   MOVEMENT DISORDERS

The global prevalence of essential tremor, with emphasis on age and sex: A meta-analysis

(2021) Peige Song et al.   Journal of Global Health

Cerebellar Oscillations in Familial and Sporadic Essential Tremor

(2021) Shi-Bing Wong et al.   CEREBELLUM

The diagnostic value of clinical neurophysiology in hyperkinetic movement disorders: A systematic review

(2021) S. van der Veen et al.   PARKINSONISM & RELATED DISORDERS

Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function

(2021) Daneck Lang-Ouellette et al.   Nature Communications

Imaging the Pathophysiology of Essential Tremor—A Systematic Review

(2021) Florian Holtbernd et al.   Frontiers in Neurology

Features of “ET plus” correlate with age and tremor duration: “ET plus” may be a disease stage rather than a subtype of essential tremor

(2021) Elan D. Louis et al.   PARKINSONISM & RELATED DISORDERS

Functional disconnection of the dentate nucleus in essential tremor

(2020) Sankalp Tikoo et al.   JOURNAL OF NEUROLOGY

Essential tremor pathology: neurodegeneration and reorganization of neuronal connections

(2020) Elan D. Louis et al.   Nature Reviews Neurology

“Essential Tremor Plus”: A Problematic Concept: Implications for Clinical and Epidemiological Studies of Essential Tremor

(2020) Elan D. Louis   NEUROEPIDEMIOLOGY

Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology

(2020) Ming-Kai Pan et al.   Science Translational Medicine

Excessive Cerebellar Oscillations in Essential Tremor: Insights Into Disease Mechanism and Treatment

(2020) Gerard Saranza et al.   MOVEMENT DISORDERS

Selective loss of the GABAAα1 subunit from Purkinje cells is sufficient to induce a tremor phenotype

(2020) Angela Nietz et al.   JOURNAL OF NEUROPHYSIOLOGY

The Pathophysiology of Dystonic Tremors and Comparison with Essential Tremor

(2020) Pattamon Panyakaew et al.   JOURNAL OF NEUROSCIENCE

Cerebello-thalamo-cortical network is intrinsically altered in essential tremor: evidence from a resting state functional MRI study

(2020) Valentina Nicoletti et al.   Scientific Reports

Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains

(2020) Whitney G. Hartstone et al.   MOVEMENT DISORDERS

Tolerability and Efficacy of Customized IncobotulinumtoxinA Injections for Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Study

(2020) Mandar Jog et al.   Toxins

Reclassifying essential tremor: Implications for the future of past research

(2019) Shweta Prasad et al.   MOVEMENT DISORDERS

Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells

(2019) Amanda M. Brown et al.   Scientific Reports

Long-term efficacy of deep brain stimulation for essential tremor

(2019) Steffen Paschen et al.   NEUROLOGY

Etiologic links between environmental and lifestyle factors and Essential tremor

(2019) Yi‐Lin Ong et al.   Annals of Clinical and Translational Neurology

Contextualizing the pathology in the essential tremor cerebellar cortex: a patholog-omics approach

(2019) Elan D. Louis et al.   ACTA NEUROPATHOLOGICA

Graph theory analysis of resting‐state functional magnetic resonance imaging in essential tremor

(2019) Julián Benito‐León et al.   HUMAN BRAIN MAPPING

Role of cerebellar GABAergic dysfunctions in the origins of essential tremor

(2019) Xu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tremor habituation to deep brain stimulation: Underlying mechanisms and solutions

(2019) Alfonso Fasano et al.   MOVEMENT DISORDERS

Whole genome sequencing and rare variant analysis in essential tremor families

(2019) Zagaa Odgerel et al.   PLoS One

Essential tremor-plus: a controversial new concept

(2019) Elan D Louis et al.   LANCET NEUROLOGY

Gene Expression Analysis of the Cerebellar Cortex in Essential Tremor

(2019) Regina T. Martuscello et al.   NEUROSCIENCE LETTERS

Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors

(2018) Muthuraman Muthuraman et al.   BRAIN

The response of the central and peripheral tremor component to octanoic acid in patients with essential tremor

(2018) Hongmei Cao et al.   CLINICAL NEUROPHYSIOLOGY

Tracking the central and peripheral origin of tremor

(2018) Ming-Kai Pan et al.   CLINICAL NEUROPHYSIOLOGY

The nature of postural tremor in Parkinson disease

(2018) Michiel F. Dirkx et al.   NEUROLOGY

Essential Tremor

(2018) Dietrich Haubenberger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Essential tremor plus is more common than essential tremor: Insights from the reclassification of a cohort of patients with lower limb tremor

(2018) Rajasumi Rajalingam et al.   PARKINSONISM & RELATED DISORDERS

Climbing fiber-Purkinje cell synaptic pathology across essential tremor subtypes

(2018) Danielle Lee et al.   PARKINSONISM & RELATED DISORDERS

Resting-state fMRI study on drug-naive patients of essential tremor with and without head tremor

(2018) Ling Wang et al.   Scientific Reports

Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1′-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor

(2017) Gabriel Martinez Botella et al.   JOURNAL OF MEDICINAL CHEMISTRY

Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society

(2017) Kailash P. Bhatia et al.   MOVEMENT DISORDERS

Role of altered cerebello-thalamo-cortical network in the neurobiology of essential tremor

(2017) Abhishek Lenka et al.   NEURORADIOLOGY

Differential Diagnosis of Parkinson Disease, Essential Tremor, and Enhanced Physiological Tremor with the Tremor Analysis of EMG

(2017) Jie Zhang et al.   Parkinsons Disease

General and selective brain connectivity alterations in essential tremor: A resting state fMRI study

(2017) Karsten Mueller et al.   NeuroImage-Clinical

Hypertrophic Olivary Degeneration and Palatal or Oculopalatal Tremor

(2017) Caroline Tilikete et al.   Frontiers in Neurology

Climbing fiber-Purkinje cell synaptic pathology in tremor and cerebellar degenerative diseases

(2016) Sheng-Han Kuo et al.   ACTA NEUROPATHOLOGICA

Deep brain stimulation and climbing fiber synaptic pathology in essential tremor

(2016) Sheng-Han Kuo et al.   ANNALS OF NEUROLOGY

Stimulating at the right time: phase-specific deep brain stimulation

(2016) Hayriye Cagnan et al.   BRAIN

Resting State fMRI Demonstrates a Disturbance of the Cerebello-Cortical Circuit in Essential Tremor

(2016) Wenjie Yin et al.   BRAIN TOPOGRAPHY

Cerebellar Pathology in Early Onset and Late Onset Essential Tremor

(2016) Sheng-Han Kuo et al.   CEREBELLUM

Early- and late-onset essential tremor patients represent clinically distinct subgroups

(2016) Franziska Hopfner et al.   MOVEMENT DISORDERS

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

(2016) W. Jeffrey Elias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Excitatory Amino acid transporter expression in the essential tremor dentate nucleus and cerebellar cortex: A postmortem study

(2016) Jie Wang et al.   PARKINSONISM & RELATED DISORDERS

Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive

(2016) Yoshiko Matsumoto-Makidono et al.   Cell Reports

Bilateral cerebellar activation in unilaterally challenged essential tremor

(2016) Marja Broersma et al.   NeuroImage-Clinical

Motor network disruption in essential tremor: a functional and effective connectivity study

(2015) Arthur W. G. Buijink et al.   BRAIN

Resetting tremor by single and paired transcranial magnetic stimulation in Parkinson’s disease and essential tremor

(2015) Ming-Kuei Lu et al.   CLINICAL NEUROPHYSIOLOGY

Essential tremor is associated with disruption of functional connectivity in the ventral intermediate Nucleus-Motor Cortex-Cerebellum circuit

(2015) Weidong Fang et al.   HUMAN BRAIN MAPPING

Essential and aging-related tremor: Differences of central control

(2015) Muthuraman Muthuraman et al.   MOVEMENT DISORDERS

Rhythmic finger tapping reveals cerebellar dysfunction in essential tremor

(2015) A.W.G. Buijink et al.   PARKINSONISM & RELATED DISORDERS

Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor

(2014) Elan D. Louis et al.   BRAIN

The nature of tremor circuits in parkinsonian and essential tremor

(2014) Hayriye Cagnan et al.   BRAIN

Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum

(2014) Chi-Ying Lin et al.   BRAIN

Functional Brain Activity Relates to 0–3 and 3–8 Hz Force Oscillations in Essential Tremor

(2014) Kristina A. Neely et al.   CEREBRAL CORTEX

Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceau

(2014) Antonin Blot et al.   NATURE NEUROSCIENCE

Modulation of Electrotonic Coupling in the Inferior Olive by Inhibitory and Excitatory Inputs: Integration in the Glomerulus

(2014) Jornt R. De Gruijl et al.   NEURON

Cerebellar Inhibitory Input to the Inferior Olive Decreases Electrical Coupling and Blocks Subthreshold Oscillations

(2014) Yaara Lefler et al.   NEURON

Decreased EAAT2 protein expression in the essential tremor cerebellar cortex

(2014) Michelle Lee et al.   Acta Neuropathologica Communications

Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau

(2013) Sheng-Han Kuo et al.   ACTA NEUROPATHOLOGICA

Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains

(2013) Rachel Babij et al.   BRAIN

Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation

(2013) Hayriye Cagnan et al.   BRAIN

Balance in essential tremor during tandem gait: Is the first mis-step an important finding?

(2013) N. Cinar et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The inferior olivary nucleus: A postmortem study of essential tremor cases versus controls

(2013) Elan D. Louis et al.   MOVEMENT DISORDERS

Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans

(2013) L. B. Hills et al.   NEUROLOGY

Elevated brain harmane (1-methyl-9H-pyrido[3,4-b]indole) in essential tremor cases vs. controls

(2013) Elan D. Louis et al.   NEUROTOXICOLOGY

T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learning

(2013) R. Ly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Worsening essential tremor following deep brain stimulation: disease progression versus tolerance

(2012) C. G. Favilla et al.   BRAIN

Cortical magnetoencephalography of deep brain stimulation for the treatment of postural tremor

(2012) Allison T. Connolly et al.   Brain Stimulation

Essential tremor and tremor in Parkinson's disease are associated with distinct ‘tremor clusters’ in the ventral thalamus

(2012) David J. Pedrosa et al.   EXPERIMENTAL NEUROLOGY

Opsoclonus: Clinical and immunological features

(2012) Joanna C. Jen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Oscillating central motor networks in pathological tremors and voluntary movements. What makes the difference?

(2012) M. Muthuraman et al.   NEUROIMAGE

Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor

(2012) S. Thier et al.   NEUROLOGY

Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in essential tremor cases in Spain

(2012) Elan D. Louis et al.   NEUROTOXICOLOGY

Defective dentate nucleus GABA receptors in essential tremor

(2011) Sarah Paris-Robidas et al.   BRAIN

Increased number of Purkinje cell dendritic swellings in essential tremor

(2011) M. Yu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity

(2010) Aasef G. Shaikh et al.   BRAIN

Increased number of heterotopic Purkinje cells in essential tremor

(2010) S.-H. Kuo et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

"Hairy Baskets” Associated With Degenerative Purkinje Cell Changes in Essential Tremor

(2010) Cordelia R. Erickson-Davis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ablation of Glutamate Receptor GluR 2 in Adult Purkinje Cells Causes Multiple Innervation of Climbing Fibers by Inducing Aberrant Invasion to Parallel Fiber Innervation Territory

(2010) T. Miyazaki et al.   JOURNAL OF NEUROSCIENCE

GABAergic Dysfunction in Essential Tremor: An 11C-Flumazenil PET Study

(2010) H. Boecker et al.   JOURNAL OF NUCLEAR MEDICINE

Disappearance of essential tremor after stroke

(2010) Michel J.-M. Dupuis et al.   MOVEMENT DISORDERS

T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor

(2010) Adrian Handforth et al.   NEUROPHARMACOLOGY

CaV3.1 is a tremor rhythm pacemaker in the inferior olive

(2010) Y.-G. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological characterization of harmaline-induced tremor activity in mice

(2009) Neil E. Paterson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Essential Tremor After Ipsilateral Cerebellar Hemispherectomy: Support for the Thalamus as the Central Oscillator

(2009) Lama M. Chahine et al.   JOURNAL OF CHILD NEUROLOGY

Local Changes in the Excitability of the Cerebellar Cortex Produce Spatially Restricted Changes in Complex Spike Synchrony

(2009) S. P. Marshall et al.   JOURNAL OF NEUROSCIENCE

Synchronized brain network associated with essential tremor as revealed by magnetoencephalography

(2009) Alfons Schnitzler et al.   MOVEMENT DISORDERS

Older onset essential tremor: More rapid progression and more degenerative pathology

(2009) Elan D. Louis et al.   MOVEMENT DISORDERS

Variant in the sequence of the LINGO1 gene confers risk of essential tremor

(2009) Hreinn Stefansson et al.   NATURE GENETICS

Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor

(2008) E LOUIS   NEUROTOXICOLOGY