Experimental Studies of the Molecular Pathways Regulated by Exercise and Resveratrol in Heart, Skeletal Muscle and the Vasculature

Multiple dietary supplements do not affect metabolic and cardiovascular health

(2016) Andreea Soare et al.   Aging-US

Resveratrol improves muscle function but not oxidative capacity in young mdx mice

(2014) Bradley S. Gordon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

(2014) Julie A. Mattison et al.   Cell Metabolism

Chronic aerobic exercise training attenuates aortic stiffening and endothelial dysfunction through preserving aortic mitochondrial function in aged rats

(2014) Qi Gu et al.   EXPERIMENTAL GERONTOLOGY

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

(2014) Louise Lantier et al.   FASEB JOURNAL

Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure

(2014) X.S. Gu et al.   GENETICS AND MOLECULAR RESEARCH

Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice

(2014) Xia Cao et al.   HYPERTENSION RESEARCH

Skeletal Muscle Mitochondria in the Elderly: Effects of Physical Fitness and Exercise Training

(2014) Nicholas T. Broskey et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men

(2014) Jesper Olesen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

(2014) Tomáš Šimůnek et al.   Pharmacological Reports

Can resveratrol help to maintain metabolic health?

(2014) Patrick Schrauwen et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Protective effect of resveratrol against pressure overload-induced heart failure

(2014) Prakash K. Gupta et al.   Food Science & Nutrition

Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice

(2013) Vernon W. Dolinsky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovariectomized mice

(2013) FLAVIA DE OLIVEIRA et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span

(2013) Julia Marchal et al.   Annals of the New York Academy of Sciences

High-Dose Resveratrol Treatment for 2 Weeks Inhibits Intestinal and Hepatic Lipoprotein Production in Overweight/Obese Men

(2013) Satya Dash et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

(2013) Vernon W. Dolinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Treadmill Exercise Prevents Learning and Memory Impairment in Alzheimer’s Disease-Like Pathology

(2013) An T. Dao et al.   Current Alzheimer Research

Resveratrol Attenuates Exercise-Induced Adaptive Responses in Rats Selectively Bred for Low Running Performance

(2013) Nikolett Hart et al.   Dose-Response

Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients

(2013) Ali Movahed et al.   Evidence-based Complementary and Alternative Medicine

Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation

(2013) Jesper Olesen et al.   EXPERIMENTAL GERONTOLOGY

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals

(2013) Anna-Maria Joseph et al.   EXPERIMENTAL GERONTOLOGY

Impact of exercise training on redox signaling in cardiovascular diseases

(2013) Juliane C. Campos et al.   FOOD AND CHEMICAL TOXICOLOGY

Resveratrol enhances exercise training responses in rats selectively bred for high running performance

(2013) Nikolett Hart et al.   FOOD AND CHEMICAL TOXICOLOGY

Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism

(2013) Albino Carrizzo et al.   HYPERTENSION

Sirtuin 1-mediated Effects of Exercise and Resveratrol on Mitochondrial Biogenesis

(2013) Keir J. Menzies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults

(2013) Rachel H.X. Wong et al.   JOURNAL OF HYPERTENSION

Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

(2013) Lasse Gliemann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Atrial Fibrillation Promotion by Endurance Exercise

(2013) Eduard Guasch et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Resveratrol Protects against Physical Fatigue and Improves Exercise Performance in Mice

(2013) Ruei-Er Wu et al.   MOLECULES

Effects of Resveratrol on the Recovery of Muscle Mass Following Disuse in the Plantaris Muscle of Aged Rats

(2013) Brian T. Bennett et al.   PLoS One

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

(2013) Kazuhiko Higashida et al.   PLOS BIOLOGY

One-Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease

(2012) João Tomé-Carneiro et al.   AMERICAN JOURNAL OF CARDIOLOGY

Resveratrol Reverses Remodeling in Hearts with Large, Old Myocardial Infarctions through Enhanced Autophagy-Activating AMP Kinase Pathway

(2012) Hiromitsu Kanamori et al.   AMERICAN JOURNAL OF PATHOLOGY

Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism

(2012) Danna M. Breen et al.   ATHEROSCLEROSIS

Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension

(2012) Fernanda R Roque et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress

(2012) Séverine Gratia et al.   CARDIOVASCULAR RESEARCH

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

(2012) Jun Yoshino et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Resveratrol improves myocardial ischemia and ischemic heart failure in mice by antagonizing the detrimental effects of fractalkine*

(2012) Wanling Xuan et al.   CRITICAL CARE MEDICINE

Resveratrol: A Natural Polyphenol with Multiple Chemopreventive Properties (Review)

(2012) Fabrizia Brisdelli et al.   CURRENT DRUG METABOLISM

Effects of Physical Exercise on Inflammatory Markers of Atherosclerosis

(2012) A. Pinto et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondria express enhanced quality as well as quantity in association with aerobic fitness across recreationally active individuals up to elite athletes

(2012) Robert A. Jacobs et al.   JOURNAL OF APPLIED PHYSIOLOGY

Post-translational Modification of Serine/Threonine Kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at Lysine Residue 97 Directly Inhibits Kinase Activity

(2012) Timothy D. Calamaras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regular treadmill exercise restores cardioprotective signaling pathways in obese mice independently from improvement in associated co-morbidities

(2012) Sandrine Pons et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Potentiating exercise training with resveratrol

(2012) R. Ventura-Clapier   JOURNAL OF PHYSIOLOGY-LONDON

Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats

(2012) Vernon W. Dolinsky et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance

(2012) Jill P. Crandall et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Potential Adverse Cardiovascular Effects From Excessive Endurance Exercise

(2012) James H. O'Keefe et al.   MAYO CLINIC PROCEEDINGS

Resveratrol Attenuates Ischemia/Reperfusion Injury in Neonatal Cardiomyocytes and Its Underlying Mechanism

(2012) Min Shen et al.   PLoS One

Of mice and men: The benefits of caloric restriction, exercise, and mimetics

(2011) Evi M. Mercken et al.   AGEING RESEARCH REVIEWS

Acute exercise activates AMPK and eNOS in the mouse aorta

(2011) José M. Cacicedo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

An acute bout of high-intensity interval training increases the nuclear abundance of PGC-1α and activates mitochondrial biogenesis in human skeletal muscle

(2011) Jonathan P. Little et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial biogenesis and PGC-1α deacetylation by chronic treadmill exercise: differential response in cardiac and skeletal muscle

(2011) Ling Li et al.   BASIC RESEARCH IN CARDIOLOGY

Calorie restriction and resveratrol in cardiovascular health and disease

(2011) Vernon W. Dolinsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

(2011) C. Zhang et al.   CARDIOVASCULAR RESEARCH

Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells

(2011) Min-Bin Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

(2011) Silvie Timmers et al.   Cell Metabolism

Exercise Protects Against Myocardial Ischemia–Reperfusion Injury via Stimulation of β 3 -Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols

(2011) John W. Calvert et al.   CIRCULATION RESEARCH

Resveratrol Improves Cardiovascular Function in DOCA-Salt Hypertensive Rats

(2011) Vincent Chan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats

(2011) Siddhartha R. Bhatt et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway

(2011) Sijo J. Thandapilly et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat

(2011) Iman Momken et al.   FASEB JOURNAL

Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms

(2011) Georgina M Ellison et al.   HEART

Determinants of time trial performance and maximal incremental exercise in highly trained endurance athletes

(2011) R. A. Jacobs et al.   JOURNAL OF APPLIED PHYSIOLOGY

Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation

(2011) Chung-Lan Kao et al.   Journal of Atherosclerosis and Thrombosis

Repeated Sprints Alter Signaling Related to Mitochondrial Biogenesis in Humans

(2011) FABIO R. SERPIELLO et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment

(2011) Keisuke Fujitaka et al.   NUTRITION RESEARCH

Effect of Exercise Training on Peak Oxygen Consumption in Patients with Cancer: A Meta-Analysis

(2011) L. W. Jones et al.   ONCOLOGIST

Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to Heart Failure

(2011) Stéphanie Rimbaud et al.   PLoS One

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise in Obesity, Metabolic Syndrome, and Diabetes

(2011) Tim Church   PROGRESS IN CARDIOVASCULAR DISEASES

Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat

(2010) J. Behbahani et al.   AMERICAN JOURNAL OF HYPERTENSION

Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72

(2010) Andreas N. Kavazis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol

(2010) Gnanapragasam Arunachalam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes

(2010) Agnieszka Biala et al.   BLOOD PRESSURE

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Resveratrol Improves Myocardial Perfusion in a Swine Model of Hypercholesterolemia and Chronic Myocardial Ischemia

(2010) M. P. Robich et al.   CIRCULATION

Cardiac Arrhythmogenic Remodeling in a Rat Model of Long-Term Intensive Exercise Training

(2010) Begoña Benito et al.   CIRCULATION

Assessing the cost-effectiveness of drug and lifestyle intervention following opportunistic screening for pre-diabetes in primary care

(2010) M. Y. Bertram et al.   DIABETOLOGIA

Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

(2010) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exercise training reduces insulin resistance and upregulates the mTOR/p70S6k pathway in cardiac muscle of diet-induced obesity rats

(2010) Cleber Medeiros et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Trans- but Not Cis-Resveratrol Impairs Angiotensin-II-Mediated Vascular Inflammation through Inhibition of NF- B Activation and Peroxisome Proliferator-Activated Receptor-  Upregulation

(2010) C. Rius et al.   JOURNAL OF IMMUNOLOGY

Resveratrol Arrests and Regresses the Development of Pressure Overload- but Not Volume Overload-Induced Cardiac Hypertrophy in Rats

(2010) Peter Wojciechowski et al.   JOURNAL OF NUTRITION

Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats

(2010) Hale Z. Toklu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

(2010) R.H.X. Wong et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome

(2010) Michael P. Robich et al.   SURGERY

Resveratrol Prevents the Development of Pathological Cardiac Hypertrophy and Contractile Dysfunction in the SHR Without Lowering Blood Pressure

(2009) S. J. Thandapilly et al.   AMERICAN JOURNAL OF HYPERTENSION

Resveratrol induces mitochondrial biogenesis in endothelial cells

(2009) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

(2009) Zoltan Ungvari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Resveratrol prevents hyperglycemia-induced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase

(2009) Qiang Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol Supplementation Gender Independently Improves Endothelial Reactivity and Suppresses Superoxide Production in Healthy Rats

(2009) Selen Soylemez et al.   CARDIOVASCULAR DRUGS AND THERAPY

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

A theoretical study of the structure–radical scavenging activity of trans-resveratrol analogues and cis-resveratrol in gas phase and water environment

(2009) Damian Mikulski et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway

(2009) Elizabeth D. Brookins Danz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol treatment protects against doxorubicin-induced cardiotoxicity by alleviating oxidative damage

(2009) Elif Tatlidede et al.   FREE RADICAL RESEARCH

Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

(2009) Anna Csiszar et al.   HYPERTENSION

Role of Proinflammatory Cytokines and Redox Homeostasis in Exercise-Induced Delayed Progression of Hypertension in Spontaneously Hypertensive Rats

(2009) Deepmala Agarwal et al.   HYPERTENSION

Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis

(2009) Keita Inanaga et al.   HYPERTENSION RESEARCH

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal Muscle AMP-activated Protein Kinase Is Essential for the Metabolic Response to Exercisein Vivo

(2009) Robert S. Lee-Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

(2008) Ryohei Miyazaki et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

(2008) Leonor Rivera et al.   BIOCHEMICAL PHARMACOLOGY

Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated mice

(2008) Takatoshi Murase et al.   BIOGERONTOLOGY

Resveratrol Attenuates Ventricular Arrhythmias and Improves the Long-Term Survival in Rats with Myocardial Infarction

(2008) You-Ren Chen et al.   CARDIOVASCULAR DRUGS AND THERAPY

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Resveratrol treatment in mice does not elicit the bradycardia and hypothermia associated with calorie restriction

(2008) Jared R. Mayers et al.   FASEB JOURNAL

Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: Role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor

(2008) Suresh Varma Penumathsa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Exercise Protects Against Doxorubicin Cardiotoxicity

(2008) Karen Y. Wonders et al.   INTEGRATIVE CANCER THERAPIES

Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt

(2008) Anita Y. M. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol reduces infarct size and improves ventricular function after myocardial ischemia in rats

(2008) Jeng-Feng Lin et al.   LIFE SCIENCES

Comparative Analysis of Bioactivities of Four Polygonum Species

(2008) Wu-Yang Huang et al.   PLANTA MEDICA

Effects of dietary polyphenols on gene expression in human vascular endothelial cells

(2008) Sonja K. Nicholson et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Exercise, oxidative stress and hormesis

(2007) Zsolt Radak et al.   AGEING RESEARCH REVIEWS

Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin

(2007) Istvan Lekli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Physical (in)activity and endothelium-derived constricting factors: overlooked adaptations

(2007) D. H. J. Thijssen et al.   JOURNAL OF PHYSIOLOGY-LONDON