Article
Biochemistry & Molecular Biology
Ana Paula Garcia Bochi, Guilherme da Silva Ferreira, Vanessa Del Bianco, Paula Ramos Pinto, Leticia Gomes Rodrigues, Mayara da Silva Trevisani, Luzia Naoko Shinohara Furukawa, Kely Cristina Soares Bispo, Alexandre Alves da Silva, Ana Paula Pereira Velosa, Edna Regina Nakandakare, Ubiratan Fabres Machado, Walcy Paganelli Rosolia Teodoro, Marisa Passarelli, Sergio Catanozi
Summary: This study found that aerobic exercise training can prevent dyslipidemia, insulin resistance, and atherogenesis induced by severe low-sodium diet. Aerobic exercise training can improve arterial lipid infiltration, reduce AT1 receptor levels, and improve peripheral insulin resistance caused by dietary restriction. Additionally, the effects of aerobic exercise training are independent of improvements in plasma lipid profile.
Article
Nutrition & Dietetics
Pauline S. Effting, Anand Thirupathi, Alexandre P. Muller, Barbara C. Pereira, Diane M. Sepa-Kishi, Luis F. B. Marqueze, Franciane T. F. Vasconcellos, Renata T. Nesi, Talita C. B. Pereira, Luiza W. Kist, Mauricio R. Bogo, Rolando B. Ceddia, Ricardo A. Pinho
Summary: This study found that ladder climbing, as a model of resistance exercise, can reverse the metabolic and inflammatory effects of high-fat diet-induced obesity in mice. The training reduced body weight, adipocyte size, improved glycemic control, and reduced inflammation in skeletal muscles.
Article
Nutrition & Dietetics
Blanca Gavilan-Carrera, Alba Ruiz-Cobo, Francisco Jose Amaro-Gahete, Alberto Soriano-Maldonado, Jose Antonio Vargas-Hitos
Summary: This study found that a 12-week aerobic training intervention did not improve anthropometry, body composition, or adherence to the Mediterranean diet in women with SLE.
Article
Pharmacology & Pharmacy
Ping-Ting Xiao, Zhi-Shen Xie, Yu-Jia Kuang, Shi-Yu Liu, Chun Zeng, Ping Li, E-Hu Liu
Summary: The study identified FKBP38 as an endogenous inhibitor of mTOR, which decreases lipid content by suppressing the mTOR/P70S6K/SREBPs pathway, effectively improving hyperlipidemia and insulin resistance.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Medicinal
Lizbeth DeSelm, Bayard Huck, Ruoxi Lan, Constantin Neagu, Justin Potnick, Yufang Xiao, Xiaoling Chen, Reinaldo Jones, Thomas E. Richardson, Brian H. Heasley, Thomas Haxell, Joseph Moore, Hui Tian, Katrin Georgi, Felix Rohdich, Amanda Sutton, Theresa Johnson, Igor Mochalkin, Jennifer Jackson, Jing Lin, Lindsey Crowley, Andreas Machl, Anderson Clark, Erik Wilker, Brian Sherer, Andreas Goutopoulos
Summary: A novel class of quinazoline carboxamides was discovered as dual p70S6k/Akt inhibitors for treating tumors driven by alterations to the PAM pathway. The lead compound, M2698, showed promising results in in vivo studies by displaying tumor control in multiple PAM pathway-driven tumors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Marcella Ramos Sant'Ana, Guilherme Francisco Peruca, Chadi Pellegrini Anaruma, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, Diego Gomes de Melo, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Leandro Pereira de Moura
Summary: The study showed that short-term combined training can reduce glucose levels and fatty liver, improve hepatic insulin sensitivity, and reduce complications caused by fatty liver.
Article
Biotechnology & Applied Microbiology
Yingnan Dai, Yeping Chen, Guoqian Wei, Li Zha, Xueqi Li
Summary: This study demonstrated that Ivabradine attenuated myocardial infarction in rats by enhancing autophagy, and the PI3K/AKT/mTOR/p70S6K pathway might be involved in this process. Activation of autophagy by Ivabradine could be a potential therapeutic strategy for the treatment of myocardial infarction.
Article
Nutrition & Dietetics
Jiabao Yan, Cuiru Ren, Yunlong Dong, Jibran A. A. Wali, Hongjie Song, Ying Zhang, Hengrui Zhang, Guangning Kou, David Raubenheimer, Zhenwei Cui
Summary: Ketogenic diet combined with moderate aerobic exercise effectively reduces body weight and fat mass, with no significant adverse effects except for an increase in circulating triglyceride level. Aerobic exercise further improves blood parameters and hepatic condition in mice fed with ketogenic diet.
Article
Nutrition & Dietetics
Linda A. Gallo, Tania F. Gallo, Sophia L. Young, Amelia K. Fotheringham, Johanna L. Barclay, Jacqueline L. Walker, Karen M. Moritz, Lisa K. Akison
Summary: There is a lack of data on whether Australian university students are meeting specific nutrient guidelines, and the study found that a large proportion of students do not meet recommendations for fruits, vegetables, fibre, calcium, and potassium. Female students especially showed low intakes of calcium and iron. Majority of students met the physical activity requirements, but there were signs of early insulin resistance in some students. Increasing intake of fruits, vegetables, and dairy, as well as focusing on iron-rich foods for females, could help correct nutrient deficiencies. While these deficiencies did not show immediate health concerns, they can have long-term effects on overall health.
Review
Endocrinology & Metabolism
Fatemeh Kazeminasab, Fatemeh Sharafifard, Maryam Miraghajani, Nasim Behzadnejad, Sara K. Rosenkranz
Summary: Exercise training has positive effects on insulin resistance and body weight in children and adolescents with overweight or obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Katherine Veras, Camila Ferraz Lucena, Julia Goedcke, Fabiana S. Evangelista, Angelo Carpinelli, Carla Roberta de Oliveira Carvalho
Summary: This study evaluated the effects of moderated aerobic treadmill exercise training on pancreatic islet cell viability and function in mice consuming a high-fat and sucrose diet. The results showed that exercise training can slow down and prevent adverse metabolic effects associated with consuming a westernized diet.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ji Zhao, Li-Ya Ma, Yong-Xin Xie, Ling-Qin Zhu, Wen-Si Ni, Rui Wang, Ya-Nan Song, Xiao-Yu Li, Hui-Fang Yang
Summary: Cyfluthrin is a widely used insecticide in sanitary pest control due to its wide insecticidal spectrum, high efficiency, low toxicity, low residue, and good biodegradability. However, the presence of residual cyfluthrin in the environment poses a risk to soil organisms and human health. This study investigates the mechanism of testicular injury induced by cyfluthrin and identifies the involvement of the STING gene and AMPK/mTOR/P70S6K autophagy pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Chen Yang, Yanchun Li, Wanye Hu, Xu Wang, Jiayu Hu, Chen Yuan, Chaoting Zhou, Hairui Wang, Jing Du, Ying Wang, Xiangmin Tong
Summary: TEOA inhibits proliferation and migration of pancreatic cancer cells by inducing mitochondrial dysfunction and ROS-dependent autophagic cell death, suggesting its potential as a promising therapeutic agent for pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Hamideh Dinari Ghozhdi, Ali Heidarianpour, Maryam Keshvari, Hassan Tavassoli
Summary: The study demonstrates that both aerobic exercise training and resistance exercise training can reduce the levels of serum adipocytokines in diabetic and non-diabetic rats. Additionally, a 4-week de-training period was found to be sufficient to reverse the metabolic adaptations gained from exercise training.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Biochemistry & Molecular Biology
Luciana da Costa Oliveira, Gustavo Paroschi Morais, Franciane Pereira de Oliveira, Milene Montavoni Mata, Allice Santos Cruz Veras, Alisson Luiz da Rocha, Lucila Leico Kagohara Elias, Giovana Rampazzo Teixeira, Camila de Moraes, Dennys E. Cintra, Eduardo R. Ropelle, Leandro P. de Moura, Jose R. Pauli, Ellen C. de Freitas, Rodrigo Rorato, Adelino Sanchez R. da Silva
Summary: Consuming a high-fat diet leads to hypothalamic inflammation and disrupts the leptin pathway, resulting in dysregulated hypothalamic neuronal activities and increased risk of obesity. Intermittent fasting and exercise training have been shown to effectively modulate hypothalamic inflammation and neuronal activity. However, it is unknown whether combining these interventions can better restore hypothalamic homeostasis in the presence of a high-fat diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Ana Paula Coelho Figueira Freire, Fabio Santos Lira, Ana Elisa von Ah Morano, Telmo Pereira, Manuel-Joao Coelho-E-Silva, Armando Caseiro, Diego Giulliano Destro Christofaro, Osmar Marchioto Junior, Gilson Pires Dorneles, Luciele Guerra Minuzzi, Ricardo Aurino Pinho, Bruna Spolador de Alencar Silva
Summary: COVID-19 can affect the autonomic nervous system and endothelial function, and its multiorgan effects may be caused by deregulations in the ANS. Investigating the differences in ANS response in overweight/obese and physically inactive individuals who had COVID-19 compared to those who did not is necessary.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Gabriel Calheiros Antunes, Robson Damasceno de Lima, Renan Fudoli Lins Vieira, Ana Paula Azevedo Macedo, Vitor Rosetto Munoz, Erika Pereira Zambalde, Caio Felipe Romeiro, Fernando Moreira Simabuco, Patricia Oliveira Prada, Adelino Sanchez Ramos da Silva, Eduardo Rochete Ropelle, Dennys Esper Cintra, Jose Rodrigo Pauli
Summary: Resistance exercise training has anti-inflammatory effects in obese mice, reducing IKKe phosphorylation and hepatic fat content. It also improves hepatic fat metabolism and glycaemic homeostasis in obese mice.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
V. R. Munoz, R. C. Gaspar, M. C. S. Mancini, R. D. de Lima, R. F. L. Vieira, B. M. Crisol, G. C. Antunes, J. C. S. Trombeta, I. L. P. Bonfante, F. M. Simabuco, A. S. R. da Silva, C. R. Cavaglieri, E. R. Ropelle, D. E. Cintra, J. R. Pauli
Summary: The study found that short-term aerobic exercise can improve overall glucose and insulin sensitivity as well as hepatic metabolism in aged rodents. These effects contribute to late-life metabolic health and help prevent the development of age-related T2D.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Gabriel Keine Kuga, Camila de Oliveira Ramos, Renan Fudoli Vieira, Thaiane da Silva Rios, Vitor Rosetto Munoz, Marcella Ramos Sant'ana, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Leandro Pereira Moura, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: Long-term high-fat diet affects adipose tissue and leads to metabolic disorders. Short-term high-fat diet affects neuronal signaling pathways. Flaxseed oil containing omega-3 fatty acids protects against increased food intake and fasting glucose, but not inflammation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Ana P. Pinto, Vitor R. Munoz, Maria Eduarda A. Tavares, Jonathas R. dos Santos, Macario A. Rebelo, Luciane C. Alberici, Fernando M. Simabuco, Giovana R. Teixeira, Jose R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Ellen C. Freitas, Donato A. Rivas, Adelino S. R. da Silva
Summary: Aging can alter the structure and function of the liver, while exercise training may have positive effects on autophagy processes, mitochondrial function, and cellular senescence in the liver. This study investigates the effects of aging and exercise on hepatic circadian markers, autophagy, and mitochondria activity using both mouse models and human datasets. The findings suggest that exercise can improve liver function and maintain mitochondrial and autophagy markers associated with liver diseases.
Article
Biochemistry & Molecular Biology
Jose R. Pauli, Vitor R. Munoz, Renan Fudoli Lins Vieira, Susana C. B. R. Nakandakari, Ana Paula Azevedo Macedo, Robson Damasceno de Lima, Gabriel Calheiros Antunes, Fernando M. Simabuco, Adelino Sanchez Ramos da Silva, Leandro P. de Moura, Eduardo R. Ropelle, Dennys E. Cintra, Rania A. Mekary, Iman Zaghloul
Summary: This study aimed to investigate the effects of gliadin on liver metabolism and inflammation and whether aerobic exercise could mitigate these effects in rodents. The results showed that gliadin administration impaired weight gain, increased gluconeogenesis and lipogenesis, and induced hepatic inflammation compared to the control group. However, exercise in combination with gliadin administration resulted in weight recovery, improved insulin sensitivity, and a reduction in gluconeogenesis, lipogenesis, and hepatic inflammation compared to the gliadin group.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Cell Biology
Gustavo Paroschi Morais, Ivo Vieira de Sousa Neto, Bruno Brieda Marafon, Eduardo R. R. Ropelle, Dennys E. E. Cintra, Jose R. Pauli, Adelino S. R. da Silva
Summary: The mechanisms of autophagy and mitochondrial function in Alzheimer's disease (AD) have been interconnected by the transcription factor EB (TFEB). Chronic exercise can activate TFEB, promoting autophagy and mitochondrial biogenesis, which may contribute to brain health and prevent AD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patricia Brito Rodrigues, Marcella Neves Datilo, Marcella Ramos Sant'Ana, Guilherme Augusto da Silva Nogueira, Rodrigo Miguel Marin, Susana Castelo Branco Ramos Nakandakari, Leandro Pereira de Moura, Adelino Sanchez Ramos da Silva, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Dennys Esper Cintra
Summary: This study tested a short-term exposure model of high-fat diets on gut alterations in mice, finding that high-fat diets resulted in increased body weight and intestinal inflammation, while flaxseed oil provided some protection against gut permeability.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Letter
Neurosciences
Jose Rodrigo Pauli, Adelino Sanchez Ramos da Silva, Ellen Cristini de Freitas
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Biochemistry & Molecular Biology
Isio Carvalho de Souza, Aline Luri Takejima, Rossana Baggio Simeoni, Luize Kremer Gamba, Victoria Stadler Tasca Ribeiro, Katia Martins Foltz, Lucia de Noronha, Meila Bastos de Almeida, Jose Rocha Faria Neto, Katherine Athayde Teixeira de Carvalho, Paulo Cesar Lock da Silveira, Ricardo Aurino Pinho, Julio Cesar Francisco, Luiz Cesar Guarita-Souza
Summary: This study aimed to evaluate the effect of BMSCs and AM therapeutic strategies on tissue repair and found that AM + BMSCs could promote skin wound healing by promoting the production of new collagen through extracellular signaling.
Article
Engineering, Biomedical
Iago Carvalho Vendramini, Calue Papcke, Pedro Soares da Veiga Neto, Christiano Francisco dos Santos, Ricardo Aurino de Pinho, Eduardo Mendonca Scheeren
Summary: The study aimed to investigate the influence of pre-sarcopenia/sarcopenia on the ability of older adults to recover postural stability during balance perturbation. The results showed that older adults with pre-sarcopenia/sarcopenia required greater ankle plantarflexor activation to remain standing in response to perturbation compared to those without sarcopenia.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2023)
Article
Immunology
Bruna Spolador de Alencar Silva, Telmo Pereira, Luciele Guerra Minuzzi, Camila Souza Padilha, Caique Figueiredo, Tiago Olean-Oliveira, Ivete Vera Medeiros dos Santos, Ana Elisa von Ah Morano, Osmar Marchioto, Jose Procopio Jabur Ribeiro, Vanessa Ribeiro Dos Santos, Marilia Seelaender, Alexandre Abilio Teixeira, Ronaldo Vagner T. Dos Santos, Valdir de Aquino Lemos, Ana Paula Coelho Figueira Freire, Gilson Pires Dorneles, Bruna Marmett, Andre Olean-Oliveira, Marcos F. S. Teixeira, Patricia M. Seraphim, Armando Caseiro, Ricardo Aurino Pinho, Hashim Islam, Jonathan Peter Little, Karsten Krueger, Jose Cesar Rosa-Neto, Manuel-Joao Coelho-E-Silva, Fabio Santos Lira
Summary: This study aimed to evaluate the association between physical activity and immunometabolic responses in young adults after mild-to-moderate COVID-19 infection. The results showed that COVID-19 patients had lower physical activity levels and exhibited impacts on lung function, immune cell phenotype, and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Luis F. B. Marqueze, Amanda K. Costa, Giulia S. Pedroso, Franciane F. Vasconcellos, Bruna I. Pilger, Schellen Kindermann, Vanessa M. Andrade, Tatyana Nery, Ana C. B. Alves, Aderbal A. Silva, Stephanie R. S. Carvalhal, Matheus F. Zazula, Katya Naliwaiko, Luiz C. Fernandes, Zsolt Radak, Ricardo A. Pinho
Summary: This study investigated the effects of physical training on behavior, redox balance, and genomic stability in models of aggressive brain cancer. The results showed that moderate aerobic exercise could have a beneficial impact on GBM treatment by improving behavior and reducing genomic instability.