Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides

In Vitro Selection of Anti-Akt2 Thioether-Macrocyclic Peptides Leading to Isoform-Selective Inhibitors

(2012) Yuuki Hayashi et al.   ACS Chemical Biology

Getting in Shape: Controlling Peptide Bioactivity and Bioavailability Using Conformational Constraints

(2012) Jonathan E. Bock et al.   ACS Chemical Biology

Reprogramming the Genetic Code: From Triplet to Quadruplet Codes

(2012) Kaihang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Macrocyclic Peptides Armed with a Mechanism-Based Warhead: Isoform-Selective Inhibition of Human Deacetylase SIRT2

(2012) Jumpei Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery, Biosynthesis, and Engineering of Lantipeptides

(2012) Patrick J. Knerr et al.   Annual Review of Biochemistry

Bioengineering natural product biosynthetic pathways for therapeutic applications

(2012) Ming-Cheng Wu et al.   CURRENT OPINION IN BIOTECHNOLOGY

In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors

(2012) Yollete V. Guillen Schlippe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Synthesis and Biological Activity of Analogues of the Lantibiotic Epilancin 15X

(2012) Patrick J. Knerr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Selection of Functional Lantipeptides

(2012) Frank T. Hofmann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation

(2012) Kazuhiro Iwasaki et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance

(2012) Arthur C. Rand et al.   MedChemComm

Flexizymes: Their Evolutionary History and the Origin of Catalytic Function

(2011) Jumpei Morimoto et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthesis of the Backbone Cyclic Peptide Sunflower Trypsin Inhibitor-1 Promoted by the Induced Peptidyl-tRNA Drop-off

(2011) Taek Jin Kang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ribosomal Synthesis of Backbone-Macrocyclic Peptides Containing γ-Amino Acids

(2011) Yukinori Ohshiro et al.   CHEMBIOCHEM

Ribosomal synthesis of backbone macrocyclic peptides

(2011) Takayuki Katoh et al.   CHEMICAL COMMUNICATIONS

Artificial lantipeptides from in vitro translations

(2011) Florian P. Seebeck et al.   CHEMICAL COMMUNICATIONS

Natural Product-Like Macrocyclic N-Methyl-Peptide Inhibitors against a Ubiquitin Ligase Uncovered from a Ribosome-Expressed De Novo Library

(2011) Yusuke Yamagishi et al.   CHEMISTRY & BIOLOGY

Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147

(2011) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fresh from the biologic pipeline—2010

(2011) Jim Kling   NATURE BIOTECHNOLOGY

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

Flexizymes for genetic code reprogramming

(2011) Yuki Goto et al.   Nature Protocols

The RNA origin of transfer RNA aminoacylation and beyond

(2011) H. Suga et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Beyond the Canonical 20 Amino Acids: Expanding the Genetic Lexicon

(2010) Travis S. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A flexizyme that selectively charges amino acids activated by a water-friendly leaving group

(2009) Nobuyoshi Niwa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

E6AP promotes the degradation of the PML tumor suppressor

(2009) I Louria-Hayon et al.   CELL DEATH AND DIFFERENTIATION

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides

(2009) Yuki Goto et al.   CHEMICAL COMMUNICATIONS

Translation Initiation with Initiator tRNA Charged with Exotic Peptides

(2009) Yuki Goto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the Lantibiotic Lactocin S Using Peptide Cyclizations on Solid Phase

(2009) Avena C. Ross et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Diverse backbone-cyclized peptides via codon reprogramming

(2009) Takashi Kawakami et al.   Nature Chemical Biology

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

The use of a cysteinyl prolyl ester (CPE) autoactivating unit in peptide ligation reactions

(2009) Toru Kawakami et al.   TETRAHEDRON

Reprogramming the Translation Initiation for the Synthesis of Physiologically Stable Cyclic Peptides

(2008) Yuki Goto et al.   ACS Chemical Biology

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ribosomal synthesis of nonstandard peptidesThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

(2008) Taek Jin Kang et al.   Biochemistry and Cell Biology

How Nature Morphs Peptide Scaffolds into Antibiotics

(2008) Elizabeth M. Nolan et al.   CHEMBIOCHEM

Messenger RNA-Programmed Incorporation of Multiple N-Methyl-Amino Acids into Linear and Cyclic Peptides

(2008) Takashi Kawakami et al.   CHEMISTRY & BIOLOGY

Synthesis of biopolymers using genetic code reprogramming

(2008) Atsushi Ohta et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Ribosomal Synthesis of Polypeptoids and Peptoid−Peptide Hybrids

(2008) Takashi Kawakami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomal Synthesis ofN-Methyl Peptides

(2008) Alexander O. Subtelny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomal Synthesis of Bicyclic Peptides via Two Orthogonal Inter-Side-Chain Reactions

(2008) Yusuke Sako et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme

(2008) Hong Xiao et al.   NATURE

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Initiating translation with D-amino acids

(2008) Y. Goto et al.   RNA