Article
Chemistry, Organic
Stefanie E. Weber, Juliane Gass, Haoxuan Zeng, Maike Erb-Brinkmann, Rainer Schobert
Summary: In this study, a stereoisomer of macrocidin B was synthesized, showing a weaker herbicidal effect compared to macrocidin A and no similar inhibitory effect on biofilms of Staphylococcus aureus.
Article
Chemistry, Multidisciplinary
Pawel M. Szczepanik, Andrey A. Mikhaylov, Ondrej Hylse, Roman Kucera, Petra Dadova, Marek Necas, Lukas Kubala, Kamil Paruch, Jakub Svenda
Summary: We report a new synthetic strategy for the flexible preparation of forskolin-like molecules. Stereoselective Michael addition and ring-opening metathesis paired with ring closure were key steps in achieving the concise assembly of the tricyclic core. Late-stage functionalization sequences transformed the tricyclic intermediates into a set of different forskolin-like molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Leonardo Kleebauer, Lieby Zborovsky, Kay Hommernick, Maria Seidel, John B. Weston, Roderich D. Suessmuth
Summary: A study synthesized and evaluated six analogues of albicidin with isosteric replacement of the key amide link, achieving protease stability while maintaining antibacterial activity. Three analogues showed up to eight times higher antibacterial activity compared to natural albicidin.
Article
Biochemistry & Molecular Biology
Junaid Ali, Mohamad Mosa Mubarak, Calvin Samuel, Hadiya Amin Kantroo, Abbass Malik, Zahoor Ahmad, Viswanathan Baskar
Summary: This study synthesized and screened a series of antimony-containing compounds, which exhibited potential bioactivity against cancer cells and bacteria.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Organic
Lan-Qin Zhao, Yun-Li Zhao, Ying-Jie He, Xing-Wei Yang, Xiao-Dong Luo
Summary: Tuberindines A and B, truffle alkaloids with intriguing structures, were discovered in Tuber indicum and have shown antihyperuricemic activity, suggesting their potential value as dietary supplements.
Article
Chemistry, Multidisciplinary
Seema Dhiman, Johann F. Ulrich, Paul Wienecke, Thomas Wichard, Hans-Dieter Arndt
Summary: Chemical mediators play a crucial role in controlling symbiotic interactions in the environment. This study presents a fully stereoselective total synthesis of (-)-thallusin, a differentiation factor in algae, and shows its potent bioactivity in Ulva mutabilis. SAR investigations suggest that (-)-thallusin triggers different pathways in Ulva that can be separated by chemical editing of the compound structure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Qing Huang, Youyi Wang, Huaimo Wu, Man Yuan, Changwu Zheng, Hongxi Xu
Summary: Xanthones are a diverse group of secondary metabolites found in various plants, fungi, lichens, and bacteria, with a majority in families such as Gentianaceae, Polygalaceae, and Clusiaceae. Xanthone glucosides, an important branch of xanthones, have potential improved characteristics after glycosylation. This review provides a comprehensive literature survey on naturally occurring xanthone glucosides, exploring their isolation, structure, bioactivity, and synthesis.
Article
Chemistry, Organic
Franziska Gillsch, Haoxuan Zeng, Sofia Baer, Hedda Schrey, Rainer Schobert
Summary: This study successfully synthesized the metabolites of Ophiosphaerella korrae, Ophiofuranones A and B. The compounds were found to be non-toxic against tumor cells, fibroblasts, and various bacteria and fungi at relevant concentrations.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Natallia V. Dubashynskaya, Anton N. Bokatyi, Tatiana S. Sall, Tatiana S. Egorova, Yuliya A. Nashchekina, Yaroslav A. Dubrovskii, Ekaterina A. Murashko, Elena N. Vlasova, Elena V. Demyanova, Yury A. Skorik
Summary: Polymeric drug delivery systems enhance the properties of antibiotics by increasing bioavailability, providing controlled-release, and reducing toxicity. This study describes the modification of conjugates based on colistin and hyaluronic acid with vitamin B12, which improved intestinal permeability, achieved slow release, and retained antimicrobial activity. These vitamin B12-modified conjugates may be promising oral delivery systems with improved biopharmaceutical properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Franziska Gillsch, Fredrick Mbui, Ursula Bilitewski, Rainer Schobert
Summary: The Penicillium metabolite thiocarboxylic A (1a) and three analogues were successfully synthesized in a modular synthetic route, which is of great significance for biological studies.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Plant Sciences
Armando Alcazar Magana, Naofumi Kamimura, Amala Soumyanath, Jan F. Stevens, Claudia S. Maier
Summary: Caffeoylquinic acids (CQAs) are plant metabolites consumed by humans through dietary intake and are beneficial for health due to their anti-inflammatory and antioxidant properties. Recent research has discovered new biosynthetic pathways and enzymes that transform CQAs, while also highlighting the need for unified nomenclature and synthetic diets for research purposes. Ongoing studies focus on biotransformation by gut microbiota, enzymatic pathways, and bioactivity assessment with potential for drug development.
Article
Chemistry, Physical
Olga Dlugosz, Marta Sochocka, Michal Ochnik, Marcin Banach
Summary: The study suggests that silver nanoparticles demonstrate the highest antimicrobial activity, especially those with a size of 97 nm. However, silver nanoparticles do not exhibit viral properties compared to copper and bimetallic nanoparticles, which have higher virus titres. Additionally, bimetallic nanoparticles combining silver and copper show no genotoxicity compared to pure metal nanoparticles.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Veselin Nasufovic, Florian Kuellmer, Johanna Boessneck, Hans-Martin Dahse, Helmar Goerls, Peter Bellstedt, Pierre Stallforth, Hans-Dieter Arndt
Summary: The first total synthesis of geodiamolide H, an actin-stabilizing marine natural product, was achieved in this study. Geodiamolide H and synthetic analogues were characterized for toxicity and antiproliferative effects, revealing a non-natural analogue with significant potential for tool compound design.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
First Ambar Wati, Mardi Santoso, Ziad Moussa, Sri Fatmawati, Arif Fadlan, Zaher M. A. Judeh
Summary: Trisindolines are heterocyclic nitrogen compounds with diverse bioactivities, synthesized by reacting isatins with indoles, showing anticancer, antimicrobial, antitubercular, antifungal activities, among others.
Review
Biochemistry & Molecular Biology
Minghui Fan, Liangbang Zou, Kaidi Tian, Guoqing Chen, Kai Cheng, Yong Li
Summary: This review provides a comprehensive coverage of stemmadenine alkaloids from early reports to July 2022, and briefly describes their diverse biological activities. Furthermore, the proposed biosynthetic pathway for stemmadenine and the conversion of stemmadenine-type alkaloids into vallesamine-type congeners are discussed in detail. Additionally, successful synthetic strategies to access the strained stemmadenine scaffolds are fully reviewed.
NATURAL PRODUCT REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Miguel A. Romero, Jose A. Gonzalez-Delgado, Johan Mendoza, Jesus F. Arteaga, Nuno Basilio, Uwe Pischel
ISRAEL JOURNAL OF CHEMISTRY
(2018)
Article
Mathematics, Applied
G. Sosa Jones, J. Arteaga, O. Jimenez
COMPUTERS & MATHEMATICS WITH APPLICATIONS
(2018)
Article
Agricultural Engineering
Juliana Navarro-Rocha, Alejandro F. Barrero, Jesus Burillo, A. Sonia Olmeda, Azucena Gonzalez-Coloma
INDUSTRIAL CROPS AND PRODUCTS
(2018)
Article
Engineering, Environmental
Francisco Rios, Alejandro Fernandez-Arteaga, Mercedes Fernandez-Serrano, Encarnacion Jurado, Manuela Lechuga
JOURNAL OF HAZARDOUS MATERIALS
(2018)
Article
Plant Sciences
Jose F. Quilez del Moral, Alvaro Perez, Maria del Mar Herrador, Alejandro F. Barrero
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Agriculture, Multidisciplinary
Sergio Perez-Burillo, Silvia Pastoriza, Alejandro Fernandez-Arteaga, German Luzon, Nuria Jimenez-Hernandez, Giuseppe D'Auria, M. Pilar Francino, Jose Angel Rufian-Henares
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Chemistry, Organic
Miguel A. Romero, Pedro Mateus, Beatriz Matos, Angel Acuna, Luis Garcia-Rio, Jesus F. Arteaga, Uwe Pischel, Nuno Basilio
JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Alberto Galisteo Pretel, Helena Perez del Pulgar, Estela Guerrero de Leon, Jose Luis Lopez-Perez, A. Sonia Olmeda, Azucena Gonzalez-Coloma, Alejandro F. Barrero, Jose Francisco Quilez del Moral
Article
Plant Sciences
Jose Francisco Quilez del Moral, Alvaro Perez, Alejandro F. Barrero
PHYTOCHEMISTRY REVIEWS
(2020)
Article
Chemistry, Organic
Jose A. Gonzalez-Delgado, Jesus F. Arteaga
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Fabio M. F. Santos, Zoe Dominguez, Joao P. L. Fernandes, Catia Parente Carvalho, Daniel Collado, Ezequiel Perez-Inestrosa, Maria V. Pinto, Adelaide Fernandes, Jesus F. Arteaga, Uwe Pischel, Pedro M. P. Gois
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Jose A. Gonzalez-Delgado, Miguel A. Romero, Francisco Bosca, Jesus F. Arteaga, Uwe Pischel
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Chemistry, Multidisciplinary
Antonio M. Borrero-Lopez, David B. Guzman, Jose Antonio Gonzalez-Delgado, Jesus F. Arteaga, Concepcion Valencia, Uwe Pischel, Jose M. Franco
Summary: The new photocured bioadhesive, using o-nitrobenzyl-protected precursor as a phototrigger for the release of diamine cadaverine, demonstrates faster curing with UV light and superior adhesion performance, reaching lap shear strength values of up to 4600 kPa. Characterization with FTIR spectroscopy reveals a well-balanced urethane/urea composition and in-depth chemical analysis, showing the direct impact on adhesion properties. Additionally, the material bonds a variety of surfaces and has approximately the same viscoelastic properties as a result of the favored fast formation of urea bonds.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Medicinal
Silvia Baldo, Patricia Antunes, Joao Falcao Felicidade, Fabio M. F. Santos, Jesus F. Arteaga, Fabio Fernandes, Uwe Pischel, Sandra N. Pinto, Pedro M. P. Gois
Summary: This study demonstrates that fluorescent boronic-acid derived salicylidenehydrazone complexes can be used as fluorescent linkers to monitor the delivery of proteasome inhibitor to cancer cells. The complexes were optimized for stability and sequestered by lipid droplets within cells, limiting hydrolysis and drug release. Conjugation with a cell-penetrating peptide improved cytoplasmic availability and potency against cancer cells.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
David Guzman Rios, Miguel A. Romero, Jose A. Gonzalez-Delgado, Jesus F. Arteaga, Uwe Pischel
Summary: The [Ru(bpy)2(Nor)2]2+ complex is an efficient catalyst for the aldol reaction of acetone with activated benzaldehydes in a buffered aqueous solution. The role of the metal as an activator for nornicotine organocatalyst ligands enhances catalytic activity by about 4.5 times compared to free nornicotine. The study provides insights into the synergistic effect of organic catalysts and metals.
JOURNAL OF ORGANIC CHEMISTRY
(2022)