Chemistry, bioactivity, biosynthesis, and total synthesis of stemmadenine alkaloids

Directed Biosynthesis of New to Nature Alkaloids in a Heterologous Nicotiana benthamiana Expression Host

(2022) Marianna Boccia et al.   Frontiers in Plant Science

Selective anti-proliferative Activity of indole alkaloids from Rhazya stricta Decne leaves

(2019) Zainab H. Abdul-Hameed et al.   LETTERS IN ORGANIC CHEMISTRY

Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow

(2019) G. D. C. Mendis et al.   Scientific Reports

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark

(2019) R. Cimanga Kanyanga et al.   JOURNAL OF ETHNOPHARMACOLOGY

Total Syntheses of Echitamine, Akuammiline, Rhazicine, and Pseudoakuammigine

(2019) Xiang Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon–Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea

(2019) Soon-Kit Wong et al.   JOURNAL OF NATURAL PRODUCTS

Six-Step Total Synthesis of (±)-Conolidine

(2019) Guoqing Chen et al.   JOURNAL OF NATURAL PRODUCTS

Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity

(2019) Bao-Bao Shi et al.   PHYTOCHEMISTRY

Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity

(2019) Tsuyoshi Arita et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Total Synthesis of Hybridaphniphylline B

(2018) Wenhao Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine

(2018) Yang Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle

(2018) Lorenzo Caputi et al.   SCIENCE

Flabellipparicine, a Flabelliformide-Apparicine-Type Bisindole Alkaloid from Tabernaemontana divaricata

(2018) You-Sheng Cai et al.   JOURNAL OF NATURAL PRODUCTS

Alstoscholactine and Alstolaxepine, Monoterpenoid Indole Alkaloids with γ-Lactone-Bridged Cycloheptane and Oxepane Moieties from Alstonia scholaris

(2018) Premanand Krishnan et al.   ORGANIC LETTERS

Structurally Diverse Indole Alkaloids from Ochrosia elliptica

(2017) Yan-Hui Fu et al.   HETEROCYCLES

Indole Alkaloids from Hunteria zeylanica

(2017) Mei-Fen Bao et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis of (±)/(+)-Subincanadine E and Determination of Absolute Configuration

(2017) Manojkumar G. Kalshetti et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of Longeracinphyllin A

(2017) Jian Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Geissoschizine synthase controls flux in the formation of monoterpenoid indole alkaloids in a Catharanthus roseus mutant

(2017) Yang Qu et al.   PLANTA

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate

(2017) Evangelos C. Tatsis et al.   Nature Communications

Total Synthesis of (+)-Conolidine by the Gold(I)-Catalyzed Cascade Cyclization of a Conjugated Enyne

(2016) Saori Naoe et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Total Syntheses of Aspidodasycarpine, Lonicerine, and the Proposed Structure of Lanciferine

(2016) Yong Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Arborisidine and Arbornamine, Two Monoterpenoid Indole Alkaloids with New Polycyclic Carbon–Nitrogen Skeletons Derived from a Common Pericine Precursor

(2016) Suet-Pick Wong et al.   ORGANIC LETTERS

Kopsiyunnanines L and M, Strychnos-related monoterpenoid indole alkaloids from Yunnan Kopsia arborea

(2016) Mariko Kitajima et al.   TETRAHEDRON

Total synthesis of conolidine and apparicine

(2016) Noriyuki Takanashi et al.   TETRAHEDRON LETTERS

Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone

(2015) Lu Liu et al.   FITOTERAPIA

A Novel Alkaloid fromAspidosperma pyricollum(Apocynaceae) and Complete1H and13C Chemical Shift Assignments

(2015) Hádria M. do Carmo et al.   HELVETICA CHIMICA ACTA

Ervatamines A–I, Anti-inflammatory Monoterpenoid Indole Alkaloids with Diverse Skeletons from Ervatamia hainanensis

(2015) Dong-Bo Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Arboridinine, a Pentacyclic Indole Alkaloid with a New Cage Carbon–Nitrogen Skeleton Derived from a Pericine Precursor

(2015) Suet-Pick Wong et al.   ORGANIC LETTERS

Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor-secovallesamine with unusual incorporation of a 3-ethylpyridine moiety

(2015) Jun-Lee Lim et al.   PHYTOCHEMISTRY

Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris

(2015) Xu-Jie Qin et al.   TETRAHEDRON

Scholarisines H–O, novel indole alkaloid derivatives from long-term stored Alstonia scholaris

(2015) Xing-Wei Yang et al.   TETRAHEDRON

Total Syntheses of Hyperforin and Papuaforins A-C, and Formal Synthesis of Nemorosone through a Gold(I)-Catalyzed Carbocyclization

(2014) Gabriel Bellavance et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-malarial activity of indole alkaloids isolated from Aspidosperma olivaceum

(2014) Talita PC Chierrito et al.   MALARIA JOURNAL

Total Synthesis of Indole Alkaloid (±)-Subincanadine E

(2014) Jingjing Tian et al.   ORGANIC LETTERS

Synthesis of (+)-Harmicine

(2014) Narshinha Argade et al.   SYNTHESIS-STUTTGART

Gardovatine, a novel Strychnos–Strychnos bisindole alkaloid with cytotoxicity from Gardneria oveta

(2013) Tao Feng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure Determination and Total Synthesis of (+)-16-Hydroxy-16,22-dihydroapparicine

(2013) Tomoyasu Hirose et al.   CHEMISTRY-A EUROPEAN JOURNAL

Alkaloids fromOchrosia borbonica

(2013) Bing-Jie Zhang et al.   HELVETICA CHIMICA ACTA

Total synthesis of the Daphniphyllum alkaloid daphenylline

(2013) Zhaoyong Lu et al.   Nature Chemistry

Total Synthesis and Stereochemical Revision of the Chlorinated Sesquiterpene (±)-Gomerone C

(2012) Nikolas Huwyler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strynuxlines A and B, Alkaloids with an Unprecedented Carbon Skeleton from Strychnos nux-vomica

(2012) Yanhui Fu et al.   JOURNAL OF NATURAL PRODUCTS

Enantioselective Cyclizations of Silyloxyenynes Catalyzed by Cationic Metal Phosphine Complexes

(2012) Jean-François Brazeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The first total synthesis and reassignment of the relative stereochemistry of 16-hydroxy-16,22-dihydroapparicine

(2012) Yoshihiko Noguchi et al.   TETRAHEDRON LETTERS

Relaxant effect and possible mechanism of 17-nor-subincanadine E in rabbit corpora cavernosa

(2011) Otacilio D Benvindo et al.   ASIAN JOURNAL OF ANDROLOGY

Synthesis of conolidine, a potent non-opioid analgesic for tonic and persistent pain

(2011) Michael A. Tarselli et al.   Nature Chemistry

Fast and Protecting-Group-Free Synthesis of (±)-Subincanadine C

(2011) Fangmiao Yu et al.   ORGANIC LETTERS

Angustilobine and andranginine type indole alkaloids and an uleine–secovallesamine bisindole alkaloid from Alstonia angustiloba

(2011) Wai-Foong Ku et al.   PHYTOCHEMISTRY

Pharmacological evaluation of Alstonia scholaris: Anti-inflammatory and analgesic effects

(2010) Jian-Hua Shang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Strychnan and Secoangustilobine A Type Alkaloids fromAlstonia spatulata.Revision of the C-20 Configuration of Scholaricine

(2010) Shin-Jowl Tan et al.   JOURNAL OF NATURAL PRODUCTS

Gold(I)-Catalyzed Enantioselective Polycyclization Reactions

(2010) Steven G. Sethofer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The first total synthesis of (±)-apparicine

(2009) M.-Lluïsa Bennasar et al.   CHEMICAL COMMUNICATIONS

Total Synthesis of the Bridged Indole Alkaloid Apparicine

(2009) M.-Lluïsa Bennasar et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Syntheses of (±)-Platencin and (−)-Platencin

(2009) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY