Review
Biochemistry & Molecular Biology
Julieann Puleo, Kornelia Polyak
Summary: Evading immune-mediated destruction is a critical step in tumor evolution, and the immune system is a strong selective pressure in tumorigenesis. Analyzing tumor immune evasion from a Darwinian perspective can provide important insights into the mechanisms of primary immune escape and acquired resistance to immunotherapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Immunology
Mariam Oladejo, Yvonne Paterson, Laurence M. Wood
Summary: Tumor immunotherapy promises to improve patient survival, with Listeria-based vaccines emerging as a promising treatment. Clinical trials have shown Listeria-based vaccines to be effective in activating anti-tumor immunity and eradicating tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Khalid Otmani, Redouane Rouas, Philippe Lewalle
Summary: Currently, microRNAs play a central role in tumorigenesis and have opened up a new avenue for understanding the communication between immune and tumor cells. The transfer of onco-miRs from tumor cells to cells in the tumor microenvironment through exosomes is an important aspect of this dialogue. This review discusses recent advances in the role of oncomiRs in promoting cancer development and modulating the immune response in the tumor immune microenvironment. MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression and can enhance or inhibit cancer development. They are categorized as oncogenes (oncomiRs) or tumor suppressor (TS) miRNAs, depending on whether they promote or suppress tumor growth. MiRNAs not only regulate pathways in cancer cells but also in the cells surrounding the tumor. It has been shown that miRNAs can be transferred between different cell types, with exosomes serving as the primary carriers. Communication between the tumor and its surrounding stromal cells through exosomes and miRNAs is crucial for cancer progression and immune suppression. Understanding the role of oncomiRs in immune suppression will aid in the development of miRNAs as biomarkers for impaired antitumor immune function and potential targets for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiongyu Hao, Yong Wu, Yanyuan Wu, Piwen Wang, Jaydutt V. Vadgama
Summary: Exosomes are small membrane-bound extracellular vesicles that mediate targeted information transfer by carrying molecular cargo. Tumor-derived exosomes (TEX) differ from normal cell-derived exosomes and have the ability to disrupt receptor discharge and intercellular cross-talk. TEX progressively weakens the immune system defenses by activating suppressive pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
You Wayne Cheah, Rawipa Intakul, Muhammad Abdus Salam, Joby Sebastian, Phuoc Hoang Ho, Prakhar Arora, Olov Ohrman, Derek Creaser, Louise Olsson
Summary: This study explores the liquefaction of Kraft lignin assisted by pyrolysis oil in a paraffin solvent. It is shown that the complex composition of pyrolysis oil can aid the depolymerization of lignin and suppress the formation of char. The functional groups present in pyrolysis oil, such as hydroxyl, methoxy, and propyl groups, have a synergistic effect in stabilizing reactive lignin intermediates. A reaction network is proposed to explain why the co-processing of pyrolysis oil and Kraft lignin completely suppressed solid char formation.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Physics, Multidisciplinary
Urska Andrensek, Primoz Ziherl, Matej Krajnc
Summary: We investigate the elasticity of an unsupported epithelial monolayer and discover that it may wrinkle even in the absence of the underlying substrate. We derive an exact elasticity theory from a cell-based model and find that wrinkling is driven by the differential apico-basal surface tension. By introducing a phantom substrate with finite stiffness beyond a critical tension, our theory is mapped onto that for supported plates, suggesting a new mechanism for tissues to control their surface patterns autonomously.
PHYSICAL REVIEW LETTERS
(2023)
Article
Oncology
Zhuo Liu, Liyuan Ge, Lei Liu, Xun Zhao, Kewei Chen, Yuxuan Li, Abudureyimujiang Aili, Min Lu, Xinlong Pei, Dengyang Han, Shudong Zhang, Lulin Ma
Summary: This study retrospectively analyzed 19 cases of retroperitoneal tumor with venous tumor thrombus and proposed a new tumor thrombus grading system. The study concluded that retroperitoneal tumor resection and removal of venous tumor thrombi are safe and effective for the treatment of such diseases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Chemical
Walid Djema, Terence Bayen, Olivier Bernard
Summary: This paper investigates the problem of species separation in minimal time. The evolution of two competing microorganism populations for the same resource is described using the Droop model. The paper focuses on solving an optimal control problem subject to a controlled system with five dimensions. The objective is to select the desired species in minimal time and synthesize an optimal feedback control. The paper provides properties of optimal controls and utilizes the Pontryagin Maximum Principle and a study of singular arcs for analysis. The theoretical results are validated using numerical examples with microalgae and a direct method in optimal control.
Article
Chemistry, Multidisciplinary
Sangmin Jeon, Eunsung Jun, Hyeyoun Chang, Ji Young Yhee, Eun-Young Koh, Yeounhee Kim, Jae Yun Jung, Eun Ji Jeong, Jong Won Lee, Man Kyu Shim, Hong Yeol Yoon, Suhwan Chang, Kwangmeyung Kim, Song Cheol Kim
Summary: This study compares the enhanced permeation and retention (EPR) effect of glycol chitosan nanoparticles (CNPs) in different pancreatic tumor models and highlights the importance of tumor microenvironment (TME) in the tumor-targeting ability of CNPs. The researchers establish patient-derived xenograft (PDX) models to predict the clinical EPR effect of CNPs in inter-patient TMEs. The findings provide a better understanding of inter-patient TME heterogeneity and complexity for personalized cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Lei Zhang, Jianli Ma, Lei Liu, Guozheng Li, Hui Li, Yi Hao, Xin Zhang, Xin Ma, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu
Summary: Cancer progression is a dynamic and evolving process that generates genetic diversity and heterogeneity through clonal and subclonal amplification based on random mutations. Traditional cancer treatment methods face the challenge of drug resistance, therefore integrating evolutionary dynamics into treatment regimens may be an effective approach. Adaptive therapy, as a potential treatment strategy, adjusts treatment cycles according to tumor evolution to control the growth of treatment-resistant cells.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Cell Biology
Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chevez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio
Summary: This study identifies an autocrine signaling pathway mediated by SFRP2 that suppresses nitric oxide production and promotes retinoblastoma growth.
Article
Oncology
Hanno S. Meyer, Benedikt Wiestler, Lisa S. Hoenikl, Claire Delbridge, Carl Ketterer, Jens Gempt, Bernhard Meyer
Summary: The mesial temporal lobe has distinct clinical and radiological features in tumor patients. In middle-aged and older patients, glioblastoma is the most common diagnosis, even without MRI contrast enhancement. Therefore, early resection may be justified in these patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiang Yu, Shan Gao, Di'an Wu, Zhengrui Li, Yan Mi, Tianyu Yang, Fan Sun, Lichen Wang, Ruoshui Liu, Shuli He, Qinggang Ge, Yang Lv, Andy (Yuanguang) Xu, Hao Zeng
Summary: The study demonstrates the highly efficient AC magnetic field heating of nanoparticles in physiological environments under clinically safe field parameters. High-performance magnetic bone cement shows effective hyperthermia suppression of tumor growth and significant enhancement of survival rate.
Article
Surgery
Gyu Young Pih, Ji Yong Ahn, Ji Young Choi, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study analyzed the risk factors and clinical outcomes of hemorrhagic duodenal GISTs, revealing a higher incidence of bleeding compared to gastric GISTs. Age, tumor size, and mitotic count were identified as risk factors for overall survival. Duodenal GISTs have a higher rate of tumor bleeding and re-bleeding after endoscopic hemostasis than gastric GISTs.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, Research & Experimental
Le Li, Zheng Chao, Un Waikeong, Jun Xiao, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma, Zhihua Wang, Zhiquan Hu, Xing Zeng
Summary: This study proposed a new metabolic classification method for renal cell carcinoma and revealed associations between metabolic profiles and immune infiltration. The subcluster with low metabolic profiles had the worst prognosis, highest invasiveness, enhanced immune infiltration but suppressive immunophenotypes. ACAA2 was identified as a tumor suppressor gene associated with increased immune infiltration and elevated PD-1 expression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Letter
Hematology
Giorgio Ottaviano, Susan Baird, Denise Bonney, Philip Connor, Michelle Cummins, Pamela Evans, Brenda Gibson, Rachel Hough, Danielle Ingham, Anne Kelly, Amrana Qureshi, Donna Lancaster, John Moppett, Alice Norton, Jeanette Payne, Simone Stockley, Sara Ghorashian, Persis Amrolia, Waseem Qasim, Ajay Vora
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Dermatology
Vignesh Jayarajan, Evangelia Kounatidou, Waseem Qasim, Wei-Li Di
Summary: Genetic skin diseases, though rare, are severe and currently lack curative treatments. Ex vivo gene modification therapy holds promise for treating these conditions by correcting mutant genes in patients' cells.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Oncology
Christos Georgiadis, Jane Rasaiyaah, Soragia Athina Gkazi, Roland Preece, Aniekan Etuk, Abraham Christi, Waseem Qasim
Summary: The use of base editing technology allows for the generation of CAR T cells with resistance to T cell fratricide, enabling enhanced cytotoxic effects against specific targets. Co-cultured 3CAR and 7CAR cells exhibit high cytotoxicity, particularly effective against CD3 + CD7 + T-ALL targets.
Article
Medicine, Research & Experimental
Julien Baruteau, Sharon C. Cunningham, Berna Seker Yilmaz, Dany P. Perocheau, Simon Eaglestone, Derek Burke, Adrian J. Thrasher, Simon N. Waddington, Leszek Lisowski, Ian E. Alexander, Paul Gissen
Summary: X-linked inherited ornithine transcarbamylase deficiency (OTCD) can lead to acute hyperammonemia despite current therapies, and liver transplantation is a curative option with risks. AAV vectors, specifically AAVLK03, were studied for treating OTCD in a non-human primate model and demonstrated safety and effectiveness in delivering the OTC gene to the liver.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2021)
Article
Cell Biology
Marc Descatoire, Remi Fritzen, Samuel Rotman, Genevieve Kuntzelman, Xavier Charles Leber, Stephanie Droz-Georget, Adrian J. Thrasher, Elisabetta Traggiai, Fabio Candotti
Summary: A main feature of Wiskott-Aldrich syndrome is increased susceptibility to autoimmunity, with WAS protein playing a key role in controlling peripheral tolerance in germinal center B cells, leading to the development of self-reactive antibodies and kidney pathology.
Article
Oncology
Giorgio Ottaviano, Waseem Qasim
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2022)
Review
Hematology
Waseem Qasim
Summary: Genome editing technologies, such as CRISPR/Cas9, are being used to overcome the challenges of allogeneic T-cell therapy for blood malignancies by disrupting TCR alpha beta and preventing graft-versus-host disease. Premanufactured banks of allogeneic donor-derived CAR T cells could help address the complex logistics and high costs of autologous therapies, if HLA-mismatched T-cell therapy can be successfully addressed. Clinical trials will be crucial in determining the safety and efficacy of these modified T-cell therapies.
Meeting Abstract
Hematology
Arnold Kloos, Christos Georgiadis, Annie Etuk, Soragia Athina Gkazi, Farhatullah Syed, Toni Braybrook, Hong Zhan, Renuka Kadirkamanathan, Nadine Kattre, Kerstin Goerlich, Thomas Fangmann, Axel Schambach, Martin G. Sauer, Michael Heuser, Waseem Qasim
Review
Biotechnology & Applied Microbiology
Chiara Bonini, Aude G. Chapuis, Michael Hudecek, Sonia Guedan, Chiara Magnani, Waseem Qasim
Summary: Gene editing technologies can address challenges in adoptive cellular therapy, such as therapy resistance, immune reactions, and immunosuppressive signals. These innovative approaches improve the efficacy and safety of cellular therapy, benefiting more patients.
HUMAN GENE THERAPY
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
A. Etuk, C. Georgiadis, R. Preece, W. Qasim
HUMAN GENE THERAPY
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
C. Georgiadis, G. Ottaviano, S. A. Gkazi, F. Syed, H. Zhan, A. Etuk, R. Preece, W. Qasim
HUMAN GENE THERAPY
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
O. Gough, R. Preece, H. Aldahshan, C. Georgiadis, W. Qasim
HUMAN GENE THERAPY
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
R. Kadirkamanathan, C. Georgiadis, A. Etuk, T. Braybrook, R. Preece, H. Zhan, W. Qasim
HUMAN GENE THERAPY
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
H. Aldahshan, R. Preece, H. Brezovjakova, C. Georgiadis, W. Qasim
HUMAN GENE THERAPY
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
H. Brezovjakova, V. Jayarajan, O. Gough, A. Etuk, A. Petrova, W. L. Di, W. Qasim
HUMAN GENE THERAPY
(2022)
