Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification

WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells

(2021) Yanan Li et al.   Frontiers in Cell and Developmental Biology

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

(2020) Florian J. Weisel et al.   NATURE IMMUNOLOGY

Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis

(2020) Miriam L. Fichtner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells

(2020) Christian T. Mayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Class-Switch Recombination Occurs Infrequently in Germinal Centers

(2019) Jonathan A. Roco et al.   IMMUNITY

Sequence features of variable region determining physicochemical properties and polyreactivity of therapeutic antibodies

(2019) Maxime Lecerf et al.   MOLECULAR IMMUNOLOGY

A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses

(2018) Simon Le Gallou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Abrogation of Lupus Nephritis in Somatic Hypermutation–Deficient MRL/lpr Mice

(2018) Fengqi Hao et al.   JOURNAL OF IMMUNOLOGY

Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination

(2018) Deborah L. Burnett et al.   SCIENCE

Metabolic Links between Plasma Cell Survival, Secretion, and Stress

(2018) Wing Y. Lam et al.   TRENDS IN IMMUNOLOGY

Triple Fluorescence staining to Evaluate Mechanism-based Apoptosis following Chemotherapeutic and Targeted Anti-cancer Drugs in Live Tumor Cells

(2018) Pradip De et al.   Scientific Reports

Intracellular transport is accelerated in early apoptotic cells

(2018) Bo Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics

(2017) Toshihiro Tanaka et al.   HEPATOLOGY

Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome

(2017) Fabio Candotti   JOURNAL OF CLINICAL IMMUNOLOGY

B cell–derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity

(2017) Tanvi Arkatkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The microanatomic segregation of selection by apoptosis in the germinal center

(2017) Christian T. Mayer et al.   SCIENCE

IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression

(2017) Nicolas Hipp et al.   Nature Communications

B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6

(2016) Shaun W. Jackson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Germinal center B cells recognize antigen through a specialized immune synapse architecture

(2016) Carla R Nowosad et al.   NATURE IMMUNOLOGY

The Roles of mTOR Complexes in Lipid Metabolism

(2015) Alexandre Caron et al.   Annual Review of Nutrition

FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production

(2015) Danyal Butt et al.   IMMUNITY

Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies

(2015) Carin I.M. Dahlberg et al.   JOURNAL OF AUTOIMMUNITY

Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients

(2015) Francesca Pala et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome

(2015) Nikita S. Kolhatkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis

(2015) Luca Piccoli et al.   Nature Communications

The role of somatic hypermutation in the generation of pathogenic antibodies in SLE

(2012) Kristin Schroeder et al.   AUTOIMMUNITY

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice

(2012) M. Recher et al.   BLOOD

Elimination of Germinal-Center-Derived Self-Reactive B Cells Is Governed by the Location and Concentration of Self-Antigen

(2012) Tyani D. Chan et al.   IMMUNITY

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

(2012) Giovanni Di Zenzo et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of VH gene rearrangement and somatic hypermutation in type 1 autoimmune pancreatitis

(2012) Fumihiro Okumura et al.   PATHOLOGY INTERNATIONAL

Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells

(2011) M. Adriani et al.   BLOOD

BH3-only protein Noxa regulates apoptosis in activated B cells and controls high-affinity antibody formation

(2011) F. M. Wensveen et al.   BLOOD

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

(2011) Shirly Becker-Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

(2011) Min Wei et al.   NATURE IMMUNOLOGY

B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses

(2010) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome

(2009) M. Bosticardo et al.   BLOOD

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

(2008) B. Mietzner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA