A comparative study of integrase-binding domain of homologous HRP2 and LEDGF/p75 protein: from sequence to structural characterisation

Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations

(2013) Karnati Konda Reddy et al.   Molecular BioSystems

Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41

(2013) Ashraf I Khasawneh et al.   Retrovirology

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

(2012) Frauke Christ et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor

(2012) Hao Wang et al.   NUCLEIC ACIDS RESEARCH

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells

(2012) Rik Schrijvers et al.   Retrovirology

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

(2012) Rik Schrijvers et al.   PLoS Pathogens

Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase

(2010) Pawan Gupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CoMFA and CoMSIA 3D-QSAR studies on quionolone caroxylic acid derivatives inhibitors of HIV-1 integrase

(2010) Peng Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

Evaluating the Performance of the ff99SB Force Field Based on NMR Scalar Coupling Data

(2009) Lauren Wickstrom et al.   BIOPHYSICAL JOURNAL

Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity

(2008) M.-C. Shun et al.   JOURNAL OF VIROLOGY