Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations
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Title
Blocking the interaction between HIV-1 integrase and human LEDGF/p75: mutational studies, virtual screening and molecular dynamics simulations
Authors
Keywords
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Journal
Molecular BioSystems
Volume 10, Issue 3, Pages 526
Publisher
Royal Society of Chemistry (RSC)
Online
2013-12-03
DOI
10.1039/c3mb70418a
References
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Note: Only part of the references are listed.- Allosteric inhibition of HIV-1 integrase activity
- (2013) Alan Engelman et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Structural and Functional Role of INI1 and LEDGF in the HIV-1 Preintegration Complex
- (2013) Benoit Maillot et al. PLoS One
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- Identification of old drugs as potential inhibitors of HIV-1 integrase – human LEDGF/p75 interaction via molecular docking
- (2012) Guoping Hu et al. JOURNAL OF MOLECULAR MODELING
- The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
- (2012) Frauke Christ et al. VIROLOGY
- Pharmacophore modelling and atom-based 3D-QSAR studies onN-methyl pyrimidones as HIV-1 integrase inhibitors
- (2011) Karnati Konda Reddy et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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- (2010) Frauke Christ et al. Nature Chemical Biology
- Computational studies of the interaction between the HIV-1 integrase tetramer and the cofactor LEDGF/p75: Insights from molecular dynamics simulations and the Informational spectrum method
- (2010) Cristina Tintori et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Strand transfer inhibitors of HIV-1 integrase: Bringing IN a new era of antiretroviral therapy
- (2009) Damian J. McColl et al. ANTIVIRAL RESEARCH
- Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex
- (2009) Manuel Tsiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75
- (2008) Li Du et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Integrase, LEDGF/p75 and HIV replication
- (2008) E. M. Poeschla CELLULAR AND MOLECULAR LIFE SCIENCES
- Identification and Characterization of PWWP Domain Residues Critical for LEDGF/p75 Chromatin Binding and Human Immunodeficiency Virus Type 1 Infectivity
- (2008) M.-C. Shun et al. JOURNAL OF VIROLOGY
- Insights into the interactions between HIV-1 integrase and human LEDGF/p75 by molecular dynamics simulation and free energy calculation
- (2008) Yaxue Zhao et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
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