Review
Plant Sciences
Luis Cervela-Cardona, Benjamin Alary, Paloma Mas
Summary: A fundamental principle shared by all organisms is the conversion of nutrients into energy, requiring precise spatiotemporal programming. Cellular metabolism can adapt to external time, relying on the circadian clock. The circadian clock plays a prevalent role in controlling the timing of mitochondrial activity and cellular energy in Arabidopsis thaliana, with evidence showing metabolic signals can feedback to the clock.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Takahiro N. Uehara, Saori Takao, Hiromi Matsuo, Ami N. Saito, Eisuke Ota, Azusa Ono, Kenichiro Itami, Toshinori Kinoshita, Takafumi Yamashino, Junichiro Yamaguchi, Norihito Nakamichi
Summary: A novel synthetic small molecule called TU-892 has been found to affect the amount of PRR7 protein, leading to lengthening of the circadian clock period in plants. The study showed that TU-892 treatment upregulates the expression of CCA1 gene and reduces the amount of PRR7 protein. This novel clock modulator provides new tools and avenues for studying the circadian clock in plants.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Beata Siemiatkowska, Matteo Chiara, Bhaskara G. Badiger, Matteo Riboni, Francesca D'Avila, Daniele Braga, Mohamed Abd Allah Salem, Damiano Martignago, Sara Colanero, Massimo Galbiati, Patrick Giavalisco, Chiara Tonelli, Thomas E. Juenger, Lucio Conti
Summary: Transcriptional reprogramming prior to morphological and physiological acclimation is crucial in drought stress responses, with the phytohormone abscisic acid (ABA) being the key signal regulating gene expression. GIGANTEA (GI) is identified as a key regulator of ABA-regulated transcriptional and physiological responses, controlling oscillations in ABA signals through DNA binding or function of different classes of transcription factors (TFs). GI plays a role in establishing a phase of reduced ABA sensitivity and related physiological responses by interacting with TFs at target regions.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Plant Sciences
Daniel A. Careno, Soledad Perez Santangelo, Richard C. Macknight, Marcelo J. Yanovsky
Summary: Circadian rhythms are regulated by a set of clock genes, and this study identified LSM1 and XRN4 as factors involved in mRNA decay pathway that affects clock function in plants.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Plant Sciences
Hikari Ikeda, Taiga Uchikawa, Yohei Kondo, Nozomu Takahashi, Takuma Shishikui, Masaaki K. Watahiki, Akane Kubota, Motomu Endo
Summary: Plants adapt to environmental changes through circadian clocks, and this study found that root hair elongation in Arabidopsis is controlled by both light and the circadian clock. Genes encoding major components of the central oscillator regulate the rhythmicity of root hair length. Grafting experiments showed that TOC1 in shoots is responsible for the generation of root hair rhythmicity.
PLANT AND CELL PHYSIOLOGY
(2023)
Article
Plant Sciences
Takahiro N. Uehara, Takashi Nonoyama, Kyomi Taki, Keiko Kuwata, Ayato Sato, Kazuhiro J. Fujimoto, Tsuyoshi Hirota, Hiromi Matsuo, Akari E. Maeda, Azusa Ono, Tomoaki T. Takahara, Hiroki Tsutsui, Takamasa Suzuki, Takeshi Yanai, Steve A. Kay, Kenichiro Itami, Toshinori Kinoshita, Junichiro Yamaguchi, Norihito Nakamichi
Summary: This study demonstrates the necessity of CDKC;2 in maintaining the circadian period in Arabidopsis. Through chemical biology and genetic approaches, it was found that CDKC;2 maintains transcriptional activity by phosphorylating the C-terminal domain of RNA polymerase II, affecting clock gene expression and period length.
PLANT AND CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Article
Plant Sciences
Luis Cervela-Cardona, Takuya Yoshida, Youjun Zhang, Masaaki Okada, Alisdair Fernie, Paloma Mas
Summary: The Arabidopsis clock component TOC1 plays a crucial role in the diurnal regulation of metabolism by repressing the expression of the TCA-related gene FUMARASE 2 at night. This regulation affects the accumulation of fumarate and contributes to the molecular and physiological energy-deprivation phenotypes of TOC1 over-expressing plants.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Article
Plant Sciences
Ami N. Saito, Akari E. Maeda, Tomoaki T. Takahara, Hiromi Matsuo, Michiya Nishina, Azusa Ono, Katsuhiro Shiratake, Michitaka Notaguchi, Takeshi Yanai, Toshinori Kinoshita, Eisuke Ota, Kazuhiro J. Fujimoto, Junichiro Yamaguchi, Norihito Nakamichi
Summary: The circadian clock, an internal time-keeping system, coordinates physiological processes. BML-259, a small molecule with CDK5/CDK2 inhibition activity, lengthens Arabidopsis circadian clock periods.
PLANT AND CELL PHYSIOLOGY
(2022)
Article
Plant Sciences
Xingwei Wang, Yanfei Hu, Wei Wang
Summary: This study compares the circadian characteristics of Arabidopsis and soybean, revealing notable differences and contrasting biological activities under circadian regulation.
Article
Multidisciplinary Sciences
Magdalena Woloszynska, Sabine Le Gall, Pia Neyt, Tommaso M. Boccardi, Marion Grasser, Gernot Laengst, Stijn Aesaert, Griet Coussens, Stijn Dhondt, Eveline Van De Slijke, Leonardo Bruno, Jorge Fung-Uceda, Paloma Mas, Marc Van Montagu, Dirk Inze, Kristiina Himanen, Geert De Jaeger, Klaus D. Grasser, Mieke Van Lijsebettens
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Plant Sciences
Meixuezi Tong, Kyounghee Lee, Daphne Ezer, Sandra Cortijo, Jaehoon Jung, Varodom Charoensawan, Mathew S. Box, Katja E. Jaeger, Nozomu Takahashi, Paloma Mas, Philip A. Wigge, Pil Joon Seo
Article
Multidisciplinary Sciences
Raquel Martins-Noguerol, Antonio Javier Moreno-Perez, Acket Sebastien, Manuel Adrian Troncoso-Ponce, Rafael Garces, Brigitte Thomasset, Joaquin J. Salas, Enrique Martinez-Force
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Sebastien Acket, Anthony Degournay, Yannick Rossez, Stephane Mottelet, Pierre Villon, Adrian Troncoso-Ponce, Brigitte Thomasset
Article
Multidisciplinary Sciences
Briardo Llorente, Salvador Torres-Montilla, Luca Morelli, Igor Florez-Sarasa, Jose Tomas Matus, Miguel Ezquerro, Lucio D'Andrea, Fakhreddine Houhou, Eszter Majer, Belen Pico, Jaime Cebolla, Adrian Troncoso, Alisdair R. Fernie, Jose-Antonio Daros, Manuel Rodriguez-Concepcion
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Plant Sciences
Antonio J. Moreno-Perez, Jose M. Santos-Pereira, Raquel Martins-Noguerol, Cristina DeAndres-Gil, M. Adrian Troncoso-Ponce, Monica Venegas-Caleron, Rosario Sanchez, Rafael Garces, Joaquin J. Salas, Juan J. Tena, Enrique Martinez-Force
Summary: Histone modifications play a crucial role in plant development. This study investigated the relationship between epigenetic modifications H3K4me3 and the expression of fatty acid-related genes and transcription factors in developing sunflower seeds, revealing the cooperation of transcription factors VIV1 and FUS3 in regulating WRINKLED 1, a key transcriptional factor in glycolysis and fatty acid synthesis in oilseeds.
Article
Agricultural Engineering
M. F. Rodriguez-Rodriguez, A. J. Moreno-Perez, S. Makni, M. A. Troncoso-Ponce, S. Acket, B. Thomasset, R. Sanchez, M. Venegas-Caleron, R. Garces, E. Martinez-Force, J. J. Salas
Summary: Camelina sativa is a preferred oil crop in plant biotechnology due to its agronomic performance, oil quality, and ease of transformation. Various strategies have been used to increase the levels of saturated and omega-7 fatty acids in camelina plants, with silencing CsKASII and expressing different alleles of thioesterases being effective methods. Co-expression of CsSAD also led to significant accumulation of omega-7 fatty acids by increasing intraplastidial desaturase activity. The different transformants produced in this study showed altered physical properties in their oils, as investigated through calorimetry studies.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Raquel Martins-Noguerol, Sebastien Acket, M. Adrian Troncoso-Ponce, Rafael Garces, Brigitte Thomasset, Monica Venegas-Caleron, Joaquin J. Salas, Enrique Martinez-Force, Antonio J. Moreno-Perez
Summary: In this study, the sunflower L1P1 and L1P2 genes were successfully isolated, sequenced, cloned, and characterized, with their expression in different tissues and impact on fatty acid and glycerolipid composition evaluated. Lipidomic studies in Arabidopsis revealed lipid remodeling in lines overexpressing these enzymes, indicating the potential regulatory role of these sunflower proteins on lipid metabolism.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Chemistry, Applied
Raquel Martins-Noguerol, Ignacio M. Perez-Ramos, Luis Matias, Xoaquin Moreira, Marta Francisco, Alberto Garcia-Gonzalez, Adrian M. Troncoso-Ponce, Brigitte Thomasset, Enrique Martinez-Force, Antonio J. Moreno-Perez, Jesus Cambrolle
Summary: This study analyzed the fruit yield, lipid, and phenolic composition of seeds from the edible halophyte Crithmum maritimum grown in different types of soil. The results showed that the seed oil content was high and had high nutritional value, while the phenolic composition contained a high amount of quercetin-type compounds with pharmaceutical interest. The study suggests that C. maritimum can be cultivated in soils with no agronomical relevance to produce seeds as a sustainable source of high-quality oil and phenolics for industrial purposes.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Review
Plant Sciences
Lu Xiong, Wenguan Zhou, Paloma Mas
Summary: The circadian clock and light signaling pathways are closely interconnected, and chromatin remodeling plays a crucial role in regulating transcription timing and light-dependent responses.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Cell Biology
Masaaki Okada, Zhiyuan Yang, Paloma Mas
Summary: This study identified the circadian components and transcriptional networks involved in generating rhythms in pistils. It revealed that pistils have organ-specific circadian autonomy and that clock activators and repressors have distinct expression patterns and regulatory functions. Genetic interaction studies also showed a hierarchy of repressing activities that contribute to the robustness and precision of the pistil clock. Additionally, the study found that circadian function in pistils primarily governs responses to environmental stimuli and photosynthesis, and controls pistil growth and seed production.
DEVELOPMENTAL CELL
(2022)
Article
Plant Sciences
Wei Wei Chen, Nozomu Takahash, Yoshito Hirata, James Ronald, Silvana Porco, Seth J. Davis, Dmitri A. Nusinow, Steve A. Kay, Paloma Mas
Article
Biotechnology & Applied Microbiology
Qingxin Song, Tien-Yu Huang, Helen H. Yu, Atsumi Ando, Paloma Mas, Misook Ha, Z. Jeffrey Chen
Article
Biology
Kyounghee Lee, Paloma Mas, Pil Joon Seo
COMMUNICATIONS BIOLOGY
(2019)
Review
Biotechnology & Applied Microbiology
Z. Jeffrey Chen, Paloma Mas