Article
Multidisciplinary Sciences
Masataka Michigami, Kentaro Takahashi, Haruna Yamashita, Zhengmao Ye, Ikuhiko Nakase, Ikuo Fujii
Summary: The generation of ligand-targeting peptidedrug conjugates (PDCs) provides a new approach for targeted intracellular drug delivery utilizing receptor-mediated endocytosis. The designed helix-loop-helix (HLH) peptide acts as the drug carrier, forming a ternary complex with VEGF and its receptor, leading to internalization into cells via VEGF receptor-mediated endocytosis. These HLH peptides and their PDCs show great potential as a new modality for targeted molecular therapy.
Article
Biochemistry & Molecular Biology
Shurong Liu, Ye Tian, Sujun Jiang, Zihua Wang
Summary: Tumor-targeting peptide-drug conjugates (PDCs) have gained attention for their potential in cancer therapy. This study presents a novel PDC molecule based on a HER-2-targeting peptide and an acid-sensitive hydrazone bond, aiming to enhance the anti-tumor effect of the drug DOX while minimizing its toxic side effects. The PDC demonstrated high cellular uptake and cytotoxicity in vitro, and effectively inhibited the growth of HER2-positive breast cancer xenografts in mice in vivo. This research offers a promising approach to overcome limitations of DOX in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Craig McDonald, Vicky L. Morrison, David McGloin, Susanna Carola Fagerholm
Summary: This study examined the role of kindlin-3 in integrin function in T cells. It was found that a mutation in the kindlin-3 binding site significantly reduced adhesion of effector T cells to the integrin ligand ICAM-1. The study also revealed that kindlin-3 binding directly affects catch bond formation and bond strength of integrin-ligand bonds.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Azam Saghaeidehkordi, Shiuan Chen, Sun Yang, Kamaljit Kaur
Summary: Chemotherapy is the main treatment for triple-negative breast cancer (TNBC), but it can be toxic to nonmalignant cells and tissues. A study showed that the K1 targeting peptide-Dox conjugate (PDC) had specific toxicity towards TNBC cells and reduced off-target toxicity, resulting in significantly improved antitumor efficacy.
Article
Biochemistry & Molecular Biology
Mayuko Suzuki, Kouta Iwaki, Moeki Kikuchi, Kei Fujiwara, Nobuhide Doi
Summary: The study found that the fusogenic peptide S19 enhances the endosomal escape efficiency of TAT-fused proteins. Mutagenesis analysis showed that the amino acids with high beta-sheet forming propensities in S19 are important for the intracellular uptake of S19-TAT fusion proteins. The appropriate linking position and order of S19 and TAT peptides were also investigated, and both the previous C-terminal S19-TAT tag and the N-terminal TAT-S19 tag promote the cytoplasmic delivery of the fusion protein.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Victor Pui-Yan Ma, Yuesong Hu, Anna Kellner, Joshua M. Brockman, Arventh Velusamy, Aaron T. Blanchard, Brian D. Evavold, Ronen Alon, Khalid Salaita
Summary: T cells defend against cancer and viral infections by binding to specific peptide antigens on target cells. It has been found that the forces transmitted through the LFA-1 /ICAM-1 complex can tune T cell signaling and enhance T cell activation and TCR discrimination.
Article
Electrochemistry
Junyu Zhang, Xinwei Wei, Yong Qiu, Weijie Yu, Yingying Xue, Yizhou Xiong, Shimeng Mou, Hangming Xiong, Yanjie Hu, Yong Zhou, Kejing Ying, Liujing Zhuang, Hao Wan, Ping Wang
Summary: Interest in measuring the mechanical properties of cardiomyocytes for drug screening and evaluation has been growing, including their contraction force and viscoelasticity. This study used Love Wave biosensors to investigate the viscoelasticity of HL-1 cardiomyocytes treated with doxorubicin hydrochloride (ADM), finding a decrease in cell viscoelasticity with increasing ADM dose. Despite lacking beating function, HL-1 cardiomyocytes were able to react to drugs and the Love Wave biosensor showed potential for early assessment of drug cardiotoxicity.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Materials Science, Multidisciplinary
Lingling Pan, Dawei Jiang, Luqi Pan, Zhizhen Meng, Yangyang Zhuang, Yueyue Huang, Fanrong Ye, Changcan Shi, Jie Chen, Jingye Pan
Summary: This study reports a strategy to specifically target inflammation sites using anti-ICAM-1 antibody bonded antibacterial peptide polymeric nanoparticles. The nanoparticles exhibit ideal antibacterial properties and targeting capabilities to inflammation endothelial cells, offering a potential treatment for sepsis.
MATERIALS & DESIGN
(2022)
Article
Pharmacology & Pharmacy
Jafrin Jobayer Sonju, Achyut Dahal, Sitanshu S. Singh, Xin Gu, William D. Johnson, Chandra Mohan Reddy Muthumula, Sharon A. Meyer, Seetharama D. Jois
Summary: This research focuses on the use of a pH-sensitive liposomal formulation and a targeting ligand conjugated cytotoxic drug to achieve targeted delivery of chemotherapy. The results showed promising in vitro and in vivo studies, indicating improved anticancer treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
George Leonidis, Anastasia Koukiali, Ioanna Sigala, Katerina Tsimaratou, Dimitris Beis, Thomas Giannakouros, Eleni Nikolakaki, Vasiliki Sarli
Summary: This study presents the optimized synthesis of JH-VII-139-1 and its c(RGDyK) peptide conjugates, and investigates their chemostability, cytotoxic and antiangiogenic properties. Most conjugates retained mid nanomolar-level inhibitory activity against SRPK1 kinase, and two conjugates showed antiproliferative effects against multiple cancer cells. In vivo zebrafish screening assays demonstrated the ability of the synthesized conjugates to inhibit intersegmental vessels. Additionally, flow cytometry experiments revealed receptor-mediated endocytosis of the conjugates in specific cancer cells.
Article
Nanoscience & Nanotechnology
Jiaojiao Chen, Yarong Song, Wenqian Yang, Jianhui Guo, Saihui Zhang, Dong Wan, Yonghui Liu, Jie Pan
Summary: In this study, tumor-targeted polymeric micelles were synthesized, and drug release was achieved through extracellular enzyme response and intracellular reduction response, thereby improving the disadvantages of chemotherapy drugs. The experiments demonstrated that this method had good anti-tumor activity in vivo and reduced toxic side effects on normal tissues.
ACS APPLIED NANO MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Su Jeong Song, Joon Sig Choi
Summary: Self-assembled peptide nanostructures are gaining attention as drug delivery systems due to their enhanced biocompatibility and biodegradability compared to polymer-based carriers. In this study, an enzyme-responsive peptide nanoparticle system was introduced, which showed effective controlled release of cargo molecules. The system exhibited good cellular uptake and biocompatibility, and demonstrated superior anticancer effects compared to the control groups.
Article
Medicine, Research & Experimental
Ryuto Tomabechi, Miki Miyasato, Taeka Sato, Tappei Takada, Kei Higuchi, Hisanao Kishimoto, Yoshiyuki Shirasaka, Katsuhisa Inoue
Summary: SLC46A3 plays an important role in therapeutic modalities, and the function of SLC46A3 can be evaluated quickly and conveniently using the fluorescent probe 5-CF.
MOLECULAR PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Zihua Zeng, Jianjun Qi, Quanyuan Wan, Youli Zu
Summary: Doxorubicin (DOX) is a common anti-tumor drug that has been utilized to form aptamer-drug conjugates for targeted cancer therapy. The synthesized Apt-TNM-DOX conjugate has high drug payloads and pH-dependent drug release, allowing for specific targeting of lymphoma cells in a simple and non-toxic manner. This targeted therapeutic approach may reduce non-specific side effects associated with traditional chemotherapy.
Article
Oncology
Yuqi Yang, Shuhang Wang, Peiwen Ma, Yale Jiang, Keman Cheng, Yue Yu, Ning Jiang, Huilei Miao, Qiyu Tang, Funan Liu, Yan Zha, Ning Li
Summary: Drug conjugates are substances that combine a tumor-homing carrier and a cytotoxic agent through a linker, designed to deliver a highly toxic drug directly to cancer cells to enhance treatment efficacy and reduce side effects. They have the potential to revolutionize current cancer treatment strategies. Besides antibody-drug conjugates, other types of drug conjugates have emerged that overcome limitations of antibodies.
Article
Computer Science, Artificial Intelligence
Siew Mooi Lim, Md. Nasir Sulaiman, Abu Bakar Md. Sultan, Norwati Mustapha, Bimo Ario Tejo
APPLIED ARTIFICIAL INTELLIGENCE
(2015)
Article
Biology
Swi See Ang, Abu Bakar Salleh, Adam Leow Thean Chor, Yahaya M. Normi, Bimo Ario Tejo, Mohd Basyaruddin Abdul Rahman
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2015)
Article
Biotechnology & Applied Microbiology
Yin Hui Chow, Yee Jiun Yap, Chin Ping Tan, Mohd Shamsul Anuar, Bimo Ario Tejo, Pau Loke Show, Arbakariya Bin Ariff, Eng-Poh Ng, Tau Chuan Ling
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2015)
Article
Chemistry, Organic
Azira Muhamad, Kok Lian Ho, Mohd Basyaruddin Abdul Rahman, Bimo A. Tejo, Dusan Uhrin, Wen Siang Tan
ORGANIC & BIOMOLECULAR CHEMISTRY
(2015)
Article
Chemistry, Physical
Rajiv K. Kar, Kamal H. Mroue, Dinesh Kumar, Bimo A. Tejo, Anirban Bhunia
JOURNAL OF PHYSICAL CHEMISTRY B
(2016)
Article
Virology
Siti Aisyah Abdul Ahmad, Uma D. Palanisamy, Bimo A. Tejo, Miaw Fang Chew, Hong Wai Tham, Sharifah Syed Hassan
Article
Biochemistry & Molecular Biology
Swi See Ang, Abu Bakar Salleh, Leow Thean Chor, Yahaya M. Normi, Bimo Ario Tejo, Mohd Basyaruddin Abdul Rahman, Mariam-Aisha Fatima
Article
Chemistry, Physical
Saadi Bayat, Bimo Ario Tejo, Abu Bakar Salleh, Emilia Abdulmalek, Yahaya M. Normi, Mohd Basyaruddin Abdul Rahman
Article
Chemistry, Medicinal
Aida Baharuddin, Asfarina Amir Hassan, Rozana Othman, Yongtao Xu, Meilan Huang, Bimo Ario Tejo, Rohana Yusof, Noorsaadah Abdul Rahman, Shatrah Othman
CHEMICAL & PHARMACEUTICAL BULLETIN
(2014)
Article
Biochemistry & Molecular Biology
Muhammad A. M. Latif, Bimo A. Tejo, Roghayeh Abedikargiban, Mohd B. Abdul Rahman, Nuno M. Micaelo
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2014)
Review
Oncology
Nian N. N. Maarof, Abdulsamad Alsalahi, Emilia Abdulmalek, Sharida Fakurazi, Bimo Ario Tejo, Mohd Basyaruddin Abdul Rahman
Summary: Randomized controlled trials have shown that first- and second-line afatinib monotherapy can improve survival in patients with NSCLC, with potential promise for R/M HNSCC. Further randomized controlled trials are needed to gather additional survival data on the efficacy of afatinib in R/M HNSCC.
Article
Biology
Izzuddin Ahmad Nadzirin, Adam Leow Thean Chor, Abu Bakar Salleh, Mohd Basyaruddin Abdul Rahman, Bimo A. Tejo
Summary: Rheumatoid arthritis is an inflammatory autoimmune disease affecting about 0.24% of the world population, and PAD4 is believed to be responsible for its occurrence. Peptide inhibitors designed to target PAD4 can reduce its activity, with P2 (Cav) showing potential as an inhibitor against PAD4 based on experimental data.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Plant Sciences
Fatin Farhana Baharuddin, Nadiah Mad Nasir, Bimo Ario Tejo, Soo Peng Koh, Shuruti Ramakrishnan, Nur Qurratu Ain A. Nordin, Anis Nasuha Adzahar, Pavithren Devakrishnan, Salsabiilaa Mohd Razib
Summary: This study discovered six compounds in the mushroom Agaricus bisporus that inhibit tyrosinase, with compounds 11 and 13 showing strong inhibition. Molecular docking simulations further revealed their binding modes with the enzyme. Based on these findings, safe skin whitening agents and treatments for pigmentation-related diseases can be developed in the cosmetic industry.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Chian Ying Teo, Bimo A. Tejo, Adam Thean Chor Leow, Abu Bakar Salleh, Mohd Basyaruddin Abdul Rahman
CHEMICAL BIOLOGY & DRUG DESIGN
(2017)
Article
Food Science & Technology
C. H. Loo, R. Ismail, M. Basri, H. L. N. Lau, B. A. Tejo, H. Abu Hassan, Y. M. Choo, M. S. Kanthimathi
JOURNAL OF OIL PALM RESEARCH
(2014)