Chromatin and the DNA damage response: The cancer connection

Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage

(2011) Feng Gong et al.   CELL CYCLE

The chromatin remodeling factor BRG1 stimulates nucleotide excision repair by facilitating recruitment of XPC to sites of DNA damage

(2011) Ling Zhang et al.   CELL CYCLE

Chromatin dynamics and the repair of DNA double strand breaks

(2011) Ye Xu et al.   CELL CYCLE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

HP1α recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

(2011) Céline Baldeyron et al.   JOURNAL OF CELL BIOLOGY

UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways

(2011) M. G. Vrouwe et al.   JOURNAL OF CELL SCIENCE

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

(2011) V. Ginjala et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

Histone acetylation by CBP and p300 at double-strand break sites facilitates SWI/SNF chromatin remodeling and the recruitment of non-homologous end joining factors

(2011) H Ogiwara et al.   ONCOGENE

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

(2011) Kristen L. Meerbrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mammalian INO80 complex is recruited to DNA damage sites in an ARP8 dependent manner

(2010) Shu-ichiro Kashiwaba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

Breaking the Diffraction Barrier: Super-Resolution Imaging of Cells

(2010) Bo Huang et al.   CELL

Assembly and function of DNA double-strand break repair foci in mammalian cells

(2010) Simon Bekker-Jensen et al.   DNA REPAIR

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

A cooperative activation loop among SWI/SNF, γ-H2AX and H3 acetylation for DNA double-strand break repair

(2010) Han-Sae Lee et al.   EMBO JOURNAL

Protein phosphatase 1γ is responsible for dephosphorylation of histone H3 at Thr 11 after DNA damage

(2010) Midori Shimada et al.   EMBO REPORTS

Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway

(2010) Xiaofeng Jiang et al.   FEBS LETTERS

p300-mediated Acetylation of Histone H3 Lysine 56 Functions in DNA Damage Response in Mammals

(2010) Rahul K. Vempati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

(2010) Ye Xu et al.   JOURNAL OF CELL BIOLOGY

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

(2010) Dorthe Helena Larsen et al.   JOURNAL OF CELL BIOLOGY

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

(2010) Ismail Hassan Ismail et al.   JOURNAL OF CELL BIOLOGY

Mass spectrometry–based proteomics in cell biology

(2010) Tobias C. Walther et al.   JOURNAL OF CELL BIOLOGY

MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

(2010) G. G. Sharma et al.   MOLECULAR AND CELLULAR BIOLOGY

MOF and H4 K16 Acetylation Play Important Roles in DNA Damage Repair by Modulating Recruitment of DNA Damage Repair Protein Mdc1

(2010) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

The ACF1 Complex Is Required for DNA Double-Strand Break Repair in Human Cells

(2010) Li Lan et al.   MOLECULAR CELL

Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1

(2010) Michael S.Y. Huen et al.   MOLECULAR CELL

Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage

(2010) Hisanobu Oda et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

(2010) Shinichiro Nakada et al.   NATURE

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes

(2010) Beth A. Helmink et al.   NATURE

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human ISWI chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites

(2010) F. Erdel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

(2010) D. M. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination

(2010) G. J. Grundy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway

(2010) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deficiency in Bre1 Impairs Homologous Recombination Repair and Cell Cycle Checkpoint Response to Radiation Damage in Mammalian Cells

(2010) Sophia B. Chernikova et al.   RADIATION RESEARCH

Involvement of Global Genome Repair, Transcription Coupled Repair, and Chromatin Remodeling in UV DNA Damage Response Changes during Development

(2010) Hannes Lans et al.   PLoS Genetics

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

(2009) Sabrina Pinato et al.   BMC MOLECULAR BIOLOGY

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

RAD6-Mediated Transcription-Coupled H2B Ubiquitylation Directly Stimulates H3K4 Methylation in Human Cells

(2009) Jaehoon Kim et al.   CELL

Recruitment of heterochromatin protein 1 to DNA repair sites

(2009) Miroslaw Zarebski et al.   CYTOMETRY PART A

14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response

(2009) Duaa H. Mohammad et al.   DNA REPAIR

53BP1 promotes ATM activity through direct interactions with the MRN complex

(2009) Ji-Hoon Lee et al.   EMBO JOURNAL

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

(2009) Yusuke Sato et al.   EMBO JOURNAL

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells

(2009) Jorrit V Tjeertes et al.   EMBO JOURNAL

Heterochromatin protein 1α: a hallmark of cell proliferation relevant to clinical oncology

(2009) Leanne De Koning et al.   EMBO Molecular Medicine

Modulation of Nucleotide Excision Repair by Mammalian SWI/SNF Chromatin-remodeling Complex

(2009) Qun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterochromatin protein 1 is recruited to various types of DNA damage

(2009) Martijn S. Luijsterburg et al.   JOURNAL OF CELL BIOLOGY

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

(2009) Jurgen A. Marteijn et al.   JOURNAL OF CELL BIOLOGY

The ubiquitin landscape at DNA double-strand breaks

(2009) Troy E. Messick et al.   JOURNAL OF CELL BIOLOGY

The Emerging Role of HP1 in the DNA Damage Response

(2009) C. Dinant et al.   MOLECULAR AND CELLULAR BIOLOGY

Human SNF5/INI1, a Component of the Human SWI/SNF Chromatin Remodeling Complex, Promotes Nucleotide Excision Repair by Influencing ATM Recruitment and Downstream H2AX Phosphorylation

(2009) A. Ray et al.   MOLECULAR AND CELLULAR BIOLOGY

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations

(2009) Noriko Shimazaki et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Linkage-Specific Avidity Defines the Lysine 63-Linked Polyubiquitin-Binding Preference of Rap80

(2009) Joshua J. Sims et al.   MOLECULAR CELL

Dealing with DNA damage: Relationships between checkpoint and repair pathways

(2009) Daniël O. Warmerdam et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

CBP/p300-mediated acetylation of histone H3 on lysine 56

(2009) Chandrima Das et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

BRIT1/MCPH1 links chromatin remodelling to DNA damage response

(2009) Guang Peng et al.   NATURE CELL BIOLOGY

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

(2009) Jun Huang et al.   NATURE CELL BIOLOGY

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

(2009) Yingli Sun et al.   NATURE CELL BIOLOGY

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

(2009) Simon Bekker-Jensen et al.   NATURE CELL BIOLOGY

The emerging role of nuclear architecture in DNA repair and genome maintenance

(2009) Tom Misteli et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation

(2009) Gyula Timinszky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis

(2009) P Nagarajan et al.   ONCOGENE

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

(2009) G. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

(2009) A. J. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

The essential function of HP1β: a case of the tail wagging the dog?

(2009) Mustafa Billur et al.   TRENDS IN BIOCHEMICAL SCIENCES

Assembly of checkpoint and repair machineries at DNA damage sites

(2009) Michael S.Y. Huen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Crosstalk between histone modifications during the DNA damage response

(2009) Haico van Attikum et al.   TRENDS IN CELL BIOLOGY

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

(2008) Midori Shimada et al.   CELL

Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites

(2008) Qianzheng Zhu et al.   DNA REPAIR

The human actin-related protein hArp5: Nucleo-cytoplasmic shuttling and involvement in DNA repair

(2008) Kumiko Kitayama et al.   EXPERIMENTAL CELL RESEARCH

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

(2008) G. Schotta et al.   GENES & DEVELOPMENT

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

(2008) E. Shema et al.   GENES & DEVELOPMENT

HP1-β is required for development of the cerebral neocortex and neuromuscular junctions

(2008) Rebecca Aucott et al.   JOURNAL OF CELL BIOLOGY

Loss of the Epigenetic Tumor Suppressor SNF5 Leads to Cancer without Genomic Instability

(2008) E. S. McKenna et al.   MOLECULAR AND CELLULAR BIOLOGY

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

(2008) Nabieh Ayoub et al.   NATURE

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

(2008) Andrew Xiao et al.   NATURE

Activation of ATM depends on chromatin interactions occurring before induction of DNA damage

(2008) Yong-Chul Kim et al.   NATURE CELL BIOLOGY

Chromatin structure and DNA damage repair

(2008) Christoffel Dinant et al.   Epigenetics & Chromatin