Protein modification by acrolein: Relevance to pathological conditions and inhibition by aldehyde sequestering agents

Aldose reductase (AKR1B3) regulates the accumulation of advanced glycosylation end products (AGEs) and the expression of AGE receptor (RAGE)

(2011) Shahid P. Baba et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Design, Synthesis, ADME Properties, and Pharmacological Activities of β-Alanyl-D-histidine (D-Carnosine) Prodrugs with Improved Bioavailability

(2011) Marica Orioli et al.   ChemMedChem

Acrolein and Neuro Disorders

(2011) Bob Weinhold   ENVIRONMENTAL HEALTH PERSPECTIVES

Brain infarction correlates more closely with acrolein than with reactive oxygen species

(2010) Ryotaro Saiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Elevated Levels of Volatile Organic Carcinogen and Toxicant Biomarkers in Chinese Women Who Regularly Cook at Home

(2010) S. S. Hecht et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Formation of a Vitamin C Conjugate of Acrolein and Its Paraoxonase-Mediated Conversion into 5,6,7,8-Tetrahydroxy-4-oxooctanal

(2010) Nicholas G. Kesinger et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxazaphosphorines: new therapeutic strategies for an old class of drugs

(2010) Bérénice Giraud et al.   Expert Opinion on Drug Metabolism & Toxicology

Lipid peroxidation product acrolein as a predictive biomarker of prostate carcinoma relapse after radical surgery

(2010) Zajim Custovic et al.   FREE RADICAL RESEARCH

β-Dicarbonyl enolates: a new class of neuroprotectants

(2010) Richard M. LoPachin et al.   JOURNAL OF NEUROCHEMISTRY

α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells

(2010) Zhihui Feng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells

(2010) Lu Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol Protects Human Retinal Pigment Epithelial Cells from Acrolein-Induced Damage

(2010) Shwu-Jiuan Sheu et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouse

(2010) G. Leung et al.   NEUROSCIENCE

Protective effects of the aqueous extract ofScutellaria baicalensisagainst acrolein-induced oxidative stress in cultured human umbilical vein endothelial cells

(2010) Xing-Wei Zhang et al.   PHARMACEUTICAL BIOLOGY

Exposure to acrolein by inhalation causes platelet activation

(2010) Srinivas D. Sithu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification of α-β unsaturated aldehydes as sources of toxicity to activated sludge biomass in polyester manufacturing wastewater

(2010) R. A. Caffaro-Filho et al.   WATER SCIENCE AND TECHNOLOGY

Change in optical properties of stratum corneum induced by protein carbonylation in vitro

(2010) I. Iwai et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury

(2010) Youngnam Cho et al.   Journal of Biological Engineering

Potential Role of Acrolein in Neurodegeneration and in Alzheimers Disease

(2010) Dang Thanh Nam et al.   Current Molecular Pharmacology

Intermediate Filament Carbonylation During Acute Acrolein Toxicity in A549 Lung Cells: Functional Consequences, Chaperone Redistribution, and Protection by Bisulfite

(2009) Philip C. Burcham et al.   ANTIOXIDANTS & REDOX SIGNALING

Water-Soluble α,β-Unsaturated Aldehydes of Cigarette Smoke Induce Carbonylation of Human Serum Albumin

(2009) Graziano Colombo et al.   ANTIOXIDANTS & REDOX SIGNALING

Edaravone Inhibits Protein Carbonylation by a Direct Carbonyl-Scavenging Mechanism: Focus on Reactivity, Selectivity, and Reaction Mechanisms

(2009) Giancarlo Aldini et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of acrolein-conjugated protein in plasma of patients with brain infarction

(2009) Madoka Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Natural Polyphenols as Direct Trapping Agents of Lipid Peroxidation-Derived Acrolein and 4-Hydroxy-trans-2-nonenal

(2009) Qin Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Modification by Acrolein: Formation and Stability of Cysteine Adducts

(2009) Jian Cai et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation

(2009) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toxicity of smoke extracts towards A549 lung cells: Role of acrolein and suppression by carbonyl scavengers

(2009) Philip C. Burcham et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Design, Synthesis, and Evaluation of Carnosine Derivatives as Selective and Efficient Sequestering Agents of Cytotoxic Reactive Carbonyl Species

(2009) Giulio Vistoli et al.   ChemMedChem

Intense correlation between protein-conjugated acrolein and primary Sjögren's syndrome

(2009) Kyohei Higashi et al.   CLINICA CHIMICA ACTA

Effects of acrolein, a natural occurring aldehyde, on the anticoagulant serpin antithrombin

(2009) I. Martínez-Martínez et al.   FEBS LETTERS

Traditional reactive carbonyl scavengers do not prevent the carbonylation of brain proteins induced by acute glutathione depletion

(2009) J. Zheng et al.   FREE RADICAL RESEARCH

Modulation of cellular function by polyamines

(2009) Kazuei Igarashi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Trapping Effects of Green and Black Tea Extracts on Peroxidation-Derived Carbonyl Substances of Seal Blubber Oil

(2009) Qin Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury

(2009) Kristin Hamann et al.   JOURNAL OF NEUROCHEMISTRY

Increased Sensitivity of Glutathione S-Transferase P-Null Mice to Cyclophosphamide-Induced Urinary Bladder Toxicity

(2009) D. J. Conklin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cruciferous Nutraceutical 3H-1,2-dithiole-3-thione Protects Human Primary Astrocytes Against Neurocytotoxicity Elicited by MPTP, MPP+, 6-OHDA, HNE and Acrolein

(2009) Zhenquan Jia et al.   NEUROCHEMICAL RESEARCH

Intense Correlation Between Brain Infarction and Protein-Conjugated Acrolein

(2009) Ryotaro Saiki et al.   STROKE

Trifluoroethanol increases albumin’s susceptibility to chemical modification

(2008) Heather D. Craig et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Transient Increase in Plasma Oxidized LDL During the Progression of Atherosclerosis in Apolipoprotein E Knockout Mice

(2008) Rina Kato et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acrolein, IL-6 and CRP as markers of silent brain infarction

(2008) Madoka Yoshida et al.   ATHEROSCLEROSIS

Oxidative stress as a biomarker of respiratory disturbance in patients with severe motor and intellectual disabilities

(2008) Naoyuki Tanuma et al.   BRAIN & DEVELOPMENT

Potent Induction of Total Cellular and Mitochondrial Antioxidants and Phase 2 Enzymes by Cruciferous Sulforaphane in Rat Aortic Smooth Muscle Cells: Cytoprotection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   Cardiovascular Toxicology

Potentialities and Pitfalls Accompanying Chemico-Pharmacological Strategies against Endogenous Electrophiles and Carbonyl Stress

(2008) Philip C. Burcham   CHEMICAL RESEARCH IN TOXICOLOGY

Genome-Wide Transcriptional Responses to Acrolein

(2008) Colin A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Albumin Is the Main Nucleophilic Target of Human Plasma: A Protective Role Against Pro-atherogenic Electrophilic Reactive Carbonyl Species?

(2008) Giancarlo Aldini et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes

(2008) Rhea Mehta et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Evaluation of N ε-(3-formyl-3,4-dehydropiperidino)lysine as a novel biomarker for the severity of diabetic retinopathy

(2008) X. Zhang et al.   DIABETOLOGIA

Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury

(2008) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity

(2008) Mubeen A. Ansari et al.   FREE RADICAL BIOLOGY AND MEDICINE

A tandem MS precursor-ion scan approach to identify variable covalent modification of albumin Cys34: a new tool for studying vascular carbonylation

(2008) Giancarlo Aldini et al.   JOURNAL OF MASS SPECTROMETRY

Critical role of acrolein in secondary injury followingex vivospinal cord trauma

(2008) Kristin Hamann et al.   JOURNAL OF NEUROCHEMISTRY

Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): Characterization of conjugation products by ESI-MSn and theoretical calculations

(2008) Giangiacomo Beretta et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quenching of α,β-unsaturated aldehydes by green tea polyphenols: HPLC–ESI–MS/MS studies

(2008) Giangiacomo Beretta et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Carbonyl-Scavenging Drugs & Protection Against Carbonyl Stress-Associated Cell Injury

(2008) P. Burcham et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases

(2008) Richard M. LoPachin et al.   NEUROTOXICOLOGY

Upregulation of cellular glutathione by 3H-1,2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity

(2008) Zhenquan Jia et al.   NEUROTOXICOLOGY

Protein Carbonyls Damage the Water-Holding Capacity of the Stratum Corneum

(2008) I. Iwai et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Acrolein health effects

(2008) O Faroon et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine

(2007) Alejandro Gugliucci   LIFE SCIENCES