Drosophila melanogaster as a model organism for Alzheimer’s disease

Drosophilaas a screening tool to study human neurodegenerative diseases

(2013) Sarah Lenz et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease–like symptoms

(2013) Minglin Lang et al.   NEUROBIOLOGY OF AGING

Transsynaptic Coordination of Synaptic Growth, Function, and Stability by the L1-Type CAM Neuroglian

(2013) Eva-Maria Enneking et al.   PLOS BIOLOGY

A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

(2013) Renee D. Read et al.   PLoS Genetics

A Novel Inhibitor of Amyloid β (Aβ) Peptide Aggregation

(2012) Angela Fortner McKoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in Drosophila

(2012) Hannes Voßfeldt et al.   PLoS One

Epidermal growth factor receptor is a preferred target for treating Amyloid- -induced memory loss

(2012) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β depresses excitatory cholinergic synaptic transmission in Drosophila

(2012) Liqun Fang et al.   Neuroscience Bulletin

A Targeted In Vivo RNAi Screen Reveals Deubiquitinases as New Regulators of Notch Signaling

(2012) Junzheng Zhang et al.   G3-Genes Genomes Genetics

Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease

(2012) Minglin Lang et al.   PLoS Genetics

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

(2011) Surendra S. Ambegaokar et al.   HUMAN MOLECULAR GENETICS

Insights fromDrosophilamodels of Alzheimer's disease

(2010) Catherine M. Cowan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Drosophila as a model to study age-related neurodegenerative disorders: Alzheimer's disease

(2010) Julia Maeve Bonner et al.   EXPERIMENTAL GERONTOLOGY

A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration

(2010) Kanae Iijima-Ando et al.   HUMAN MOLECULAR GENETICS

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in aDrosophilamodel of Alzheimer’s disease

(2009) Thomas Rival et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Aβ exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease

(2009) James Folwell et al.   EXPERIMENTAL NEUROLOGY

What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?

(2009) Dawn Teschendorf et al.   Molecular Neurodegeneration

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Protein folding diseases and neurodegeneration: Lessons learned from yeast

(2008) Joris Winderickx et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of Novel Genes That Modify Phenotypes Induced by Alzheimer's  -Amyloid Overexpression in Drosophila

(2008) W. Cao et al.   GENETICS

Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function

(2008) Katia Carmine-Simmen et al.   NEUROBIOLOGY OF DISEASE

Aβ42 Mutants with Different Aggregation Profiles Induce Distinct Pathologies in Drosophila

(2008) Koichi Iijima et al.   PLoS One

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE