Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway

Mutant huntingtin-impaired degradation of β-catenin causes neurotoxicity in Huntington's disease

(2010) Juliette D Godin et al.   EMBO JOURNAL

Mouse models of Huntington's disease and methodological considerations for therapeutic trials

(2009) Robert J. Ferrante   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin

(2009) Gerardo A Morfini et al.   NATURE NEUROSCIENCE

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease

(2008) Chuan-En Wang et al.   HUMAN MOLECULAR GENETICS

ABL2/ARG Tyrosine Kinase Mediates SEMA3F-induced RhoA Inactivation and Cytoskeleton Collapse in Human Glioma Cells

(2008) Akio Shimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Microtubule Assembly in Osteoblasts Stimulates Bone Morphogenetic Protein 2 Expression and Bone Formation through Transcription Factor Gli2

(2008) M. Zhao et al.   MOLECULAR AND CELLULAR BIOLOGY

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

(2008) Barbara L. Apostol et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1  and oxidative phosphorylation

(2008) Z. Arany et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular functions of GEF-H1, a microtubule-regulated Rho-GEF: is altered GEF-H1 activity a crucial determinant of disease pathogenesis?

(2008) Jörg Birkenfeld et al.   TRENDS IN CELL BIOLOGY

Pharmacological inhibition of RhoA signaling prevents connective tissue growth factor induction in endothelial cells exposed to non-uniform shear stress

(2007) Iwona Cicha et al.   ATHEROSCLEROSIS

Diverse roles of Rho family GTPases in neuronal development, survival, and death

(2007) Daniel et al.   Frontiers in Bioscience-Landmark