The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review

The genetic basis for aortic aneurysmal disease

(2014) Athanasios Saratzis et al.   HEART

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

(2014) E. Tsika et al.   HUMAN MOLECULAR GENETICS

Pharmacological chaperones stabilize retromer to limit APP processing

(2014) Vincent J Mecozzi et al.   Nature Chemical Biology

Frequency of the ASP620ASN mutation in VPS35 and Arg1205His mutation in EIF4G1 in familial Parkinson's disease from South Italy

(2014) Monica Gagliardi et al.   NEUROBIOLOGY OF AGING

Progranulin protein levels are differently regulated in plasma and CSF

(2014) A. M. Nicholson et al.   NEUROLOGY

The SORL1 polymorphism rs985421 may confer the risk for amnestic mild cognitive impairment and Alzheimer's disease in the Han Chinese population

(2014) Chunhui Jin et al.   NEUROSCIENCE LETTERS

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

The Retromer Complex Is Required for Rhodopsin Recycling and Its Loss Leads to Photoreceptor Degeneration

(2014) Shiuan Wang et al.   PLOS BIOLOGY

Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype

(2013) G Izzo et al.   Clinics

DNAJC13 mutations in Parkinson disease

(2013) Carles Vilariño-Güell et al.   HUMAN MOLECULAR GENETICS

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

(2013) Xin Wang et al.   NATURE MEDICINE

Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration

(2013) Corey T. McMillan et al.   NEUROBIOLOGY OF AGING

Whole exome sequencing of rare variants in EIF4G1 and VPS35 in Parkinson disease

(2013) K. Nuytemans et al.   NEUROLOGY

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Association between the SORL1 rs2070045 polymorphism and late-onset Alzheimer's disease: Interaction with the ApoE genotype in the Chinese Han population

(2013) Xiaofan Xue et al.   NEUROSCIENCE LETTERS

The Genetic Variation of SORCS1 Is Associated with Late-Onset Alzheimer’s Disease in Chinese Han Population

(2013) Wei Xu et al.   PLoS One

Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort

(2013) Lyzel S. Elias-Sonnenschein et al.   PLoS One

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

(2013) Akinori Miyashita et al.   PLoS One

Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction

(2013) Tilman Breiderhoff et al.   PLoS One

Genome-Wide Profiling of the Activity-Dependent Hippocampal Transcriptome

(2013) Guido Hermey et al.   PLoS One

A mechanism for retromer endosomal coat complex assembly with cargo

(2013) M. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer

(2013) Jordan Follett et al.   TRAFFIC

SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET

(2013) Simon Glerup et al.   Cell Reports

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)

(2013) C Reitz et al.   Translational Psychiatry

Discovery and replication of gene influences on brain structure using LASSO regression

(2013) Omid Kohannim   Frontiers in Neuroscience

Identification of Alzheimer Disease Risk Genotype That Predicts Efficiency of SORL1 Expression in the Brain

(2012) Safak Caglayan   ARCHIVES OF NEUROLOGY

Frequency of the D620N Mutation in VPS35 in Parkinson Disease

(2012) Kishore R. Kumar et al.   ARCHIVES OF NEUROLOGY

Multi-compartmental modeling of SORLA’s influence on amyloidogenic processing in Alzheimer’s disease

(2012) Angelyn Lao et al.   BMC Systems Biology

SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population

(2012) Hui-Fu Wang et al.   BRAIN RESEARCH

Association of SORL1 Alleles with Late-Onset Alzheimer's Disease. Findings from the GIGAS_LOAD Study and Mega-Analysis

(2012) Paolo Olgiati et al.   Current Alzheimer Research

SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer’s disease

(2012) Liang-Hao Guo et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Genome-wide analysis of epistasis in body mass index using multiple human populations

(2012) Wen-Hua Wei et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The retromer complex - endosomal protein recycling and beyond

(2012) M. N. J. Seaman   JOURNAL OF CELL SCIENCE

A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants

(2012) Manu Sharma et al.   JOURNAL OF MEDICAL GENETICS

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

(2012) A. W. Fjorback et al.   JOURNAL OF NEUROSCIENCE

Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes

(2012) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Rab GTPase regulation of retromer-mediated cargo export during endosome maturation

(2012) Ting-Ting Liu et al.   MOLECULAR BIOLOGY OF THE CELL

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

(2012) C Pottier et al.   MOLECULAR PSYCHIATRY

VPS35mutation in Japanese patients with typical Parkinson's disease

(2012) Maya Ando et al.   MOVEMENT DISORDERS

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

(2012) Akhil Bhalla et al.   NEUROBIOLOGY OF DISEASE

Identification of VPS35 mutations replicated in French families with Parkinson disease

(2012) S. Lesage et al.   NEUROLOGY

Npas4: A Neuronal Transcription Factor with a Key Role in Social and Cognitive Functions Relevant to Developmental Disorders

(2012) Laurence Coutellier et al.   PLoS One

Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in thetrans-Golgi network

(2012) Regina Wai-Yan Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sortilin-related VPS10 domain containing receptor 1 and Alzheimer's disease-associated allelic variations preferentially exist in female or type 2 diabetes mellitus patients in southern Han Chinese

(2012) Yanqin HE et al.   Psychogeriatrics

Sortilin: a receptor to regulate neuronal viability and function

(2012) Anders Nykjaer et al.   TRENDS IN NEUROSCIENCES

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease

(2011) Christiane Reitz   ARCHIVES OF NEUROLOGY

Sortilin: An unusual suspect in cholesterol metabolism

(2011) Joseph B. Dubé et al.   BIOESSAYS

RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons

(2011) Liang Qiang et al.   CELL

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

(2011) Vanessa Schmidt et al.   EMBO JOURNAL

Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

(2011) Sarah Felice Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin

(2011) Gina M. Finan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei

(2011) V. L. Koumandou et al.   JOURNAL OF CELL SCIENCE

cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression

(2011) E. Benito et al.   JOURNAL OF NEUROSCIENCE

Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-Methyl-D-Aspartate Receptor 2C (NR2C)

(2011) L. Cai et al.   MOLECULAR AND CELLULAR BIOLOGY

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

(2011) Paul Temkin et al.   NATURE CELL BIOLOGY

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

Retromer disruption promotes amyloidogenic APP processing

(2011) Christopher P. Sullivan et al.   NEUROBIOLOGY OF DISEASE

Impact of Genetic Variation in SORCS1 on Memory Retention

(2011) Christiane Reitz et al.   PLoS One

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

(2011) B. Balana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

(2011) K. Deinhardt et al.   Science Signaling

Rare Copy Number Variation Discovery and Cross-Disorder Comparisons Identify Risk Genes for ADHD

(2011) A. C. Lionel et al.   Science Translational Medicine

SNX-BAR-Mediated Endosome Tubulation is Co-ordinated with Endosome Maturation

(2011) Jan R.T. van Weering et al.   TRAFFIC

Amyloid-β-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population

(2010) Mei Ning et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma

(2010) Minerva M. Carrasquillo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk

(2010) Christiane Reitz et al.   ANNALS OF NEUROLOGY

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

(2010) Benjamin E.L. Lauffer et al.   JOURNAL OF CELL BIOLOGY

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

(2010) M. E. Harbour et al.   JOURNAL OF CELL SCIENCE

Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-  Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

(2010) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

(2010) Sandra I Vieira et al.   Molecular Neurodegeneration

Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

(2010) A Christoforou et al.   MOLECULAR PSYCHIATRY

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease

(2010) Elliott J. Mufson et al.   NEUROSCIENCE LETTERS

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

(2010) D. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EHD proteins: key conductors of endocytic transport

(2010) Naava Naslavsky et al.   TRENDS IN CELL BIOLOGY

Implication of Sex and SORL1 Variants in Italian Patients With Alzheimer Disease

(2009) Elena Cellini et al.   ARCHIVES OF NEUROLOGY

Association of SORL1 gene variants with Alzheimer's disease

(2009) Heike Kölsch et al.   BRAIN RESEARCH

The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport

(2009) Zhi Hong et al.   CELL RESEARCH

The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

(2009) Thomas Wassmer et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

A Genome-Wide Association Study Identifies a Novel Major Locus for Glycemic Control in Type 1 Diabetes, as Measured by Both A1C and Glucose

(2009) A. D. Paterson et al.   DIABETES

Proteomic Analysis of GLUT4 Storage Vesicles Reveals LRP1 to Be an Important Vesicle Component and Target of Insulin Signaling

(2009) Mark P. Jedrychowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5

(2009) M. N. J. Seaman et al.   JOURNAL OF CELL SCIENCE

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

(2009) Karrie E Grear et al.   Molecular Neurodegeneration

Sequence variation in SORL1 and dementia risk in Swedes

(2009) Chandra A. Reynolds et al.   NEUROGENETICS

SORL1 is genetically associated with Alzheimer disease in a Japanese population

(2009) Ryo Kimura et al.   NEUROSCIENCE LETTERS

The Function of Activity-Regulated Genes in the Nervous System

(2009) Sven Loebrich et al.   PHYSIOLOGICAL REVIEWS

A Role for the CHC22 Clathrin Heavy-Chain Isoform in Human Glucose Metabolism

(2009) S. Vassilopoulos et al.   SCIENCE

Association of Distinct Variants in SORL1 With Cerebrovascular and Neurodegenerative Changes Related to Alzheimer Disease

(2008) Karen T. Cuenco   ARCHIVES OF NEUROLOGY

Possible Association between SORL1 and Alzheimer Disease?

(2008) Joseph H. Lee et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population

(2008) Karolien Bettens et al.   HUMAN MUTATION

Genomic convergence to identify candidate genes for Alzheimer Disease on chromosome 10

(2008) Xueying Liang et al.   HUMAN MUTATION

Opposing Activities of the Snx3-Retromer Complex and ESCRT Proteins Mediate Regulated Cargo Sorting at a Common Endosome

(2008) Todd I. Strochlic et al.   MOLECULAR BIOLOGY OF THE CELL

Activity-dependent regulation of inhibitory synapse development by Npas4

(2008) Yingxi Lin et al.   NATURE

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Influence of SORL1 gene variants: Association with CSF amyloid-β products in probable Alzheimer's disease

(2008) Heike Kölsch et al.   NEUROSCIENCE LETTERS

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex

(2008) Brett M. Collins et al.   TRAFFIC

SORL1 haplotypes modulate risk of Alzheimer's disease in Chinese

(2007) E.K. Tan et al.   NEUROBIOLOGY OF AGING

SORL1 variants and risk of late-onset Alzheimer’s disease

(2007) Yonghong Li et al.   NEUROBIOLOGY OF DISEASE