Sortilin: An unusual suspect in cholesterol metabolism

Sorting Out Sortilin

(2011) Alan R. Tall et al.   CIRCULATION RESEARCH

Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export

(2010) Mads Kjolby et al.   Cell Metabolism

Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease

(2010) Irina A. Kirpich et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials

(2010)   LANCET

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease

(2010) Elliott J. Mufson et al.   NEUROSCIENCE LETTERS

Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip

(2009) Philippa J. Talmud et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet

(2009) Sandra Jimena Hernández Vallejo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Large Scale Association Analysis of Novel Genetic Loci for Coronary Artery Disease

(2009)   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease

(2009) Patrick Linsel-Nitschke et al.   ATHEROSCLEROSIS

The Vps10p-domain receptor family

(2009) Guido Hermey   CELLULAR AND MOLECULAR LIFE SCIENCES

The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes

(2009) Jibin Zeng et al.   EXPERIMENTAL CELL RESEARCH

Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample

(2009) Matthew B. Lanktree et al.   JOURNAL OF LIPID RESEARCH

Plasma lipoproteins: genetic influences and clinical implications

(2009) Robert A. Hegele   NATURE REVIEWS GENETICS

Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia

(2008) Chris Wallace et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Endocytosis of Apolipoprotein A-V by Members of the Low Density Lipoprotein Receptor and the Vps10p Domain Receptor Families

(2008) Stefan K. Nilsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol

(2008) Nilesh J. Samani et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

LDL-cholesterol concentrations: a genome-wide association study

(2008) Manjinder S Sandhu et al.   LANCET

Translating molecular discoveries into new therapies for atherosclerosis

(2008) Daniel J. Rader et al.   NATURE

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

(2008) Cristen J Willer et al.   NATURE GENETICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE

Mapping the Genetic Architecture of Gene Expression in Human Liver

(2008) Eric E Schadt et al.   PLOS BIOLOGY