Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses

Autophagy takes place in mutated p53 neuroblastoma cells in response to hypoxia mimetic CoCl2

(2013) Thomas Naves et al.   BIOCHEMICAL PHARMACOLOGY

The TP53 tumor suppressor and autophagy in malignant lymphoma

(2012) Zijun Y. Xu-Monette et al.   Autophagy

p53 Ser15phosphorylation disrupts the p53–RPA70 complex and induces RPA70-mediated DNA repair in hypoxia

(2012) Esha Madan et al.   BIOCHEMICAL JOURNAL

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

(2012) Sophie Doublier et al.   BMC CANCER

The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

(2012) Madhavsai Gajjar et al.   CANCER CELL

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

(2012) Claudia Capparelli et al.   CELL CYCLE

mTORC1 and p53

(2012) Paul Hasty et al.   CELL CYCLE

AG490 Promotes HIF-1α Accumulation by Inhibiting Its Hydroxylation

(2012) R. Fernandez-Sanchez et al.   CURRENT MEDICINAL CHEMISTRY

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

(2012) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer metabolism: current perspectives and future directions

(2012) C Muñoz-Pinedo et al.   Cell Death & Disease

Phosphorylation of Carbonic Anhydrase IX Controls Its Ability to Mediate Extracellular Acidification in Hypoxic Tumors

(2011) P. Ditte et al.   CANCER RESEARCH

Revisiting the ABCs of Multidrug Resistance in Cancer Chemotherapy

(2011) Amit K. Tiwari et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain

(2011) Eliska Svastova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chaperoning of Mutant p53 Protein by Wild-type p53 Protein Causes Hypoxic Tumor Regression

(2011) Rajan Gogna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia

(2011) Mikael Altun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α effects on angiogenic potential in human small cell lung carcinoma

(2011) Jun Wan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The metabolic advantage of tumor cells

(2011) Maurice Israël et al.   Molecular Cancer

Hypoxia and Senescence: The Impact of Oxygenation on Tumor Suppression

(2011) S. M. Welford et al.   MOLECULAR CANCER RESEARCH

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element

(2011) J Xu et al.   ONCOGENE

Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death

(2011) C Wanka et al.   ONCOGENE

The asparaginyl hydroxylase factor-inhibiting HIF is essential for tumor growth through suppression of the p53–p21 axis

(2011) J Pelletier et al.   ONCOGENE

Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival

(2011) Sigve Andersen et al.   PLoS One

Systems Analysis of ATF3 in Stress Response and Cancer Reveals Opposing Effects on Pro-Apoptotic Genes in p53 Pathway

(2011) Yujiro Tanaka et al.   PLoS One

Two-phase dynamics of p53 in the DNA damage response

(2011) X.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frataxin participates to the hypoxia-induced response in tumors

(2011) I Guccini et al.   Cell Death & Disease

Reciprocal influence of the p53 and the hypoxic pathways

(2011) A Sermeus et al.   Cell Death & Disease

HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers

(2010) Yoshifumi Baba et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWIST

(2010) C.-C. Tsai et al.   BLOOD

Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease

(2010) Marielle Ousset et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Role of autophagy in suppression of inflammation and cancer

(2010) Eileen White et al.   CURRENT OPINION IN CELL BIOLOGY

Hypoxia and energetic tumour metabolism

(2010) M Christiane Brahimi-Horn et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output

(2010) Lihong Chen et al.   EMBO JOURNAL

Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors

(2010) Dermot O'Toole et al.   ENDOCRINE-RELATED CANCER

Renal Oxygenation Suppresses VHL Loss-Induced Senescence That Is Caused by Increased Sensitivity to Oxidative Stress

(2010) S. M. Welford et al.   MOLECULAR AND CELLULAR BIOLOGY

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

(2010) Hakan Cam et al.   MOLECULAR CELL

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

(2010) Zhaohui Feng et al.   TRENDS IN CELL BIOLOGY

The key hypoxia regulated gene CAIX is upregulated in basal-like breast tumours and is associated with resistance to chemotherapy

(2009) E Y Tan et al.   BRITISH JOURNAL OF CANCER

Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model

(2009) An Wouters et al.   CANCER LETTERS

Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors

(2009) A.-T. Henze et al.   CANCER RESEARCH

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Kinases as Upstream Regulators of the HIF System: Their Emerging Potential as Anti-Cancer Drug Targets

(2009) Elitsa Dimova et al.   CURRENT PHARMACEUTICAL DESIGN

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Targeting Hypoxia in Cancer Cells by Restoring Homeodomain Interacting Protein-Kinase 2 and p53 Activity and Suppressing HIF-1α

(2009) Lavinia Nardinocchi et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Clinicopathologic significance of HIF-1α, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer

(2008) Sung Yong Oh et al.   BMC CANCER

Poorer outcome in stromal HIF-2α- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis

(2008) A H G Cleven et al.   BRITISH JOURNAL OF CANCER

p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway

(2008) N.V. Khromova et al.   CANCER LETTERS

ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer

(2008) T. Migita et al.   CANCER RESEARCH

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths

(2008) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mRNA controls p53 activity by managing Mdm2 functions

(2008) Marco M. Candeias et al.   NATURE CELL BIOLOGY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE

PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

(2008) G Xenaki et al.   ONCOGENE

New roles for pyruvate kinase M2: working out the Warburg effect

(2008) Emily C. Ferguson et al.   TRENDS IN BIOCHEMICAL SCIENCES