Article
Agriculture, Dairy & Animal Science
Jaco Bakker, Melissa A. de la Garza
Summary: This article provides a comprehensive review of endocrine disorders in non-human primates (NHP) through an extensive literature search. The diagnosis of endocrine disorders in NHP is often incidental and lacks clinical signs. The pancreas is the most commonly affected endocrine organ, and diabetes mellitus is the most clinically significant disorder. Currently, there is no standard procedure for diagnosing, monitoring, or treating endocrine disorders in NHP.
Review
Cell Biology
Chiaho Shih, Szu-Yao Wu, Shu-Fan Chou, Ta-Tung Thomas Yuan
Summary: Mutant 97L of HBc in chronic hepatitis B patients exhibits an immature secretion phenotype, contrary to the dogma of wild type HBV virion secretion predominantly containing mature double-stranded DNA genomes. Aberrant behaviors in virion secretion were observed in other naturally occurring HBc variants, possibly mediated by compensatory mutations. Virion secretion regulated by HBV genome maturity could be a potential target for antiviral drug development.
Article
Biochemistry & Molecular Biology
Md Sharear Saon, Brent M. Znosko
Summary: RNA folding is hierarchical and involves predicting secondary structure before tertiary structure. Secondary structure prediction is based on free energy minimization, and for accurate prediction, all types of secondary structure motifs need to be characterized. The current model for predicting the stability of pentaloops, a specific secondary structure motif, is not accurate enough. By identifying common pentaloops and conducting experiments, a new pentaloop-specific model with improved accuracy was derived.
Article
Veterinary Sciences
Jared A. Jaffey, Ogi Okwumabua, Thomas K. Graves, Layla Al-Nakkash, Ross Monasky, Alec Wilson, Shankar Thangamani
Summary: The intestinal mycobiome is altered in diabetic dogs, with an increased prevalence of Candida spp. and higher quantitative fungal growth. Female dogs are more likely to have fungi colonization. Our results suggest that glycemic control may be associated with the growth of Candida spp. in diabetic dogs.
VETERINARY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Richard Kwamla Amewu, Patrick Opare Sakyi, Dorcas Osei-Safo, Ivan Addae-Mensah
Summary: Cancer is a complex disease with drugs targeting potential multiple targets being proposed as cutting-edge treatments. However, drug resistance, systemic toxicity, and ineffectiveness in various cancer treatments remain widespread issues. Therefore, efficient therapeutic agents targeting multiple targets in different cancer cells are suggested.
Article
Evolutionary Biology
Martin M. Vila-Aiub, Heping Han, Qin Yu, Federico Garcia, Stephen B. Powles
Summary: The study on single and double EPSPS mutations in glyphosate-resistant weed species indicated significant impact on survival and reproductive capabilities of Eleusine indica plants, with the double TIPS mutation favoring plant reproduction.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Immunology
Qiaoli Peng, Runhong Zhou, Na Liu, Hui Wang, Haoran Xu, Meiqing Zhao, Dawei Yang, Ka-Kit Au, Haode Huang, Li Liu, Zhiwei Chen
Summary: This study found that spike mutations in SARS-CoV-2 variants can enhance viral transmissibility and immune evasion, affecting vaccine immunogenicity. Designing vaccines targeting these variants is crucial to overcome immune evasion from current vaccines and neutralizing antibodies.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li-Kun Yang, Zhi-Shuai Hou, Ya-Xiong Tao
Summary: GPCRs are crucial in transmitting extracellular signals and regulating physiological functions. Mutations in GPCRs can lead to diseases and studying biased agonism provides insights into disease pathogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
Munkhzaya Byambaragchaa, Tae-Young Ahn, Seung-Hee Choi, Myung-Hwa Kang, Kwan-Sik Min
Summary: This study investigated mutations involved in the activation of FSH receptor (FSHR) and found that the activating mutant eFSHR-D566G greatly enhances signal transduction in response to FSH, even without agonist treatment.
Review
Medicine, General & Internal
Livia-Cristiana Baicoianu-Nilescu, Ana-Maria Gheorghe, Mara Carsote, Mihai Cristian Dumitrascu, Florica Sandru
Summary: Non-endocrine findings in MEN1 syndrome include skin lesions, particularly tumor-type lesions. This narrative review summarizes the clinical presentation of cutaneous tumors and other dermatological issues in patients with MEN1, and also discusses the association between MEN1 gene and melanomas.
Review
Chemistry, Applied
Chuan-he Tang
Summary: This review discusses the utilization of naturally occurring protein architectures as nanovehicles for hydrophobic nutraceuticals or drugs, through a disassembly and reassembly strategy. Various strategies and techniques for mediating the disassembly and reassembly of these architectures are comprehensively reviewed. Reassembled protein nanoparticles have been shown to be outstanding nanovehicles for improving water dispersion and bioactivities of nutraceuticals or drugs.
FOOD HYDROCOLLOIDS
(2021)
Article
Microbiology
C. M. Senthil Kumar, T. K. Jacob, S. Devasahayam, C. Geethu, V. Hariharan
Summary: This study reports the natural infection of Conogethes punctiferalis by the entomopathogenic fungus Metarhizium pingshaense, which showed high virulence against the pest. The isolated strain holds promise for the development of a potential mycoinsecticide against C. punctiferalis.
MICROBIOLOGICAL RESEARCH
(2021)
Article
Chemistry, Physical
Yugang Liu, Huiping Xia, Shiyin Guo, Xiangyang Lu, Chaoxi Zeng
Summary: In this study, it was found that ursolic acid can form self-stabilized Pickering emulsion with excellent sediment stability except under low water fraction or low particle concentration conditions. Additionally, the viscoelastic properties of the emulsions can be improved by increasing particle concentration or water fraction.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Endocrinology & Metabolism
Amanda J. Seabrook, Jessica E. Harris, Sofia B. Velosa, Edward Kim, Aideen M. McInerney-Leo, Trisha Dwight, Jason Hockings, Nicholas G. Hockings, Judy Kirk, Paul J. Leo, Amanda J. Love, Catherine Luxford, Mhairi Marshall, Ozgur Mete, David J. Pennisi, Matthew A. Brown, Anthony J. Gill, Gregory Hockings, Roderick J. Clifton-Bligh, Emma L. Duncan
Summary: Pathogenic germline MAX variants are associated with multiple tumors including pheochromocytoma, ganglioneuroma, neuroblastoma, and pituitary neuroendocrine tumors. Clinical, genetic, immunohistochemical, and functional studies on affected families confirmed the associations. Immunohistochemistry and functional studies provided additional evidence for the roles of MAX variants in tumor development.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Genetics & Heredity
Sally Badawi, Feda E. Mohamed, Nesreen R. Alkhofash, Anne John, Amanat Ali, Bassam R. Ali
Summary: This study investigated the potential effects of 28 missense variants on the subcellular trafficking and targeting of the ACE2 receptor. The results showed that none of the studied missense variants had a significant impact on ACE2 intracellular trafficking and subcellular targeting to the plasma membrane, including the predicted deleterious variants. Further research is needed to investigate the effects of ACE2 variants on viral susceptibility and severity.
Article
Oncology
Sara Molatore, Andrea Kuegler, Martin Irmler, Tobias Wiedemann, Frauke Neff, Annette Feuchtinger, Johannes Beckers, Mercedes Robledo, Federico Roncaroli, Natalia S. Pellegata
ENDOCRINE-RELATED CANCER
(2018)
Article
Biology
Vanja Radulovic, Theresa Heider, Sabine Richter, Simone Moertl, Michael J. Atkinson, Natasa Anastasov
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2017)
Article
Biology
Ramesh Yentrapalli, Juliane Merl-Pham, Omid Azimzadeh, Lisa Mutschelknaus, Carsten Peters, Stefanie M. Hauck, Michael J. Atkinson, Soile Tapio, Simone Moertl
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2017)
Article
Multidisciplinary Sciences
Valerie Brd O'Leary, Sarah Hain, Doris Maugg, Jan Smida, Omid Azimzadeh, Soile Tapio, Saak Victor Ovsepian, Michael John Atkinson
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
I. Gonzalez-Vasconcellos, R. Schneider, N. Anastasov, S. Alonso-Rodriguez, B. Sanli-Bonazzi, J. L. Fernandez, M. J. Atkinson
SCIENTIFIC REPORTS
(2017)
Article
Biology
Sisko Salomaa, Elisabeth Cardis, Simon D. Bouffler, Michael J. Atkinson, Nobuyuki Hamada
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2020)
Article
Cell Biology
Aglaja Kopf, Joerg Renkawitz, Robert Hauschild, Irute Girkontaite, Kerry Tedford, Jack Merrin, Oliver Thorn-Seshold, Dirk Trauner, Hans Haecker, Klaus-Dieter Fischer, Eva Kiermaier, Michael Sixt
JOURNAL OF CELL BIOLOGY
(2020)
Review
Biology
Sisko Salomaa, Simon D. Bouffler, Michael J. Atkinson, Elisabeth Cardis, Nobuyuki Hamada
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2020)
Article
Biology
Carmen Kessel, Michael J. Atkinson, Thomas E. Schmid, Klaus Trott, Jan J. Wilkens, Natasa Anastasov, Michael Rosemann, Omid Azimzadeh, Soile Tapio, Simone Moertl, Ulrike M. Kulka, Michael Abend, Matthias Port, Christina Beinke, Mona Mustafa, Frauke Neff, Daniela Pfeiffer, Pascal Berberat, Stephanie E. Combs
Summary: The MSc Radiation Biology program has been evaluated over the last five years, showing a diverse student cohort with different nationalities and undergraduate backgrounds. Measures taken after regular quality meetings and student feedback have led to improvements in curriculum, workload, teacher training, and examination regulations.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Cell Biology
Aglaja Kopf, Eva Kiermaier
Summary: The organization of microtubule arrays in immune cells is crucial for their effector functions in immune responses. Leukocytes mainly use centrosomes for microtubule nucleation, allowing for plastic MTOC localization and dynamics to adapt to different environmental conditions, highlighting the importance of microtubule involvement in cell shape maintenance and physical coherence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paul Kern, Nora R. Balzer, Nelli Blank, Cornelia Cygon, Klaus Wunderling, Franziska Bender, Alex Frolov, Jan-Peter Sowa, Lorenzo Bonaguro, Thomas Ulas, Mirka Homrich, Eva Kiermaier, Christoph Thiele, Joachim L. Schultze, Ali Canbay, Reinhard Bauer, Elvira Mass
Summary: Creld2 plays a crucial role in regulating protein folding and cell stress response, enhancing the UPR and regulating energy expenditure. Lack of Creld2 may lead to UPR dysregulation and hepatic steatosis.
Article
Cell Biology
Thomas Quast, Karolin Zoelzer, Donald Guu, Luis Alvarez, Carsten Kuesters, Eva Kiermaier, U. Benjamin Kaupp, Waldemar Kolanus
Summary: This study used a combination of microfluidics and quantitative in vitro live cell imaging to investigate the chemotactic sensing strategy of dendritic cells (DCs). The results showed that spatial sensing mechanisms are essential for the persistent chemotaxis of DCs in stable gradients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Ann-Kathrin Weier, Mirka Homrich, Stephanie Ebbinghaus, Pavel Juda, Eliska Mikova, Robert Hauschild, Lili Zhang, Thomas Quast, Elvira Mass, Andreas Schlitzer, Waldemar Kolanus, Sven Burgdorf, Oliver J. Gruss, Miroslav Hons, Stefan Wieser, Eva Kiermaier
Summary: Centrosomes play a crucial role in immune cell interactions and immune response initiation. Immune activation leads to the emergence of extra centrosomes in leukocytes, which contribute to cell migration, secretion of inflammatory cytokines, and optimized T cell responses. These findings highlight the previously underestimated importance of extra centrosomes in cell and tissue homeostasis.
JOURNAL OF CELL BIOLOGY
(2022)
Editorial Material
Biology
Isabel Stoetzel, Eva Kiermaier
Summary: The centrosome plays a crucial role in determining which branches extending from the body of microglia will successfully engulf and clear away dead neurons.
Article
Endocrinology & Metabolism
Simona Borsari, Elena Pardi, Natalia S. Pellegata, Misu Lee, Federica Saponaro, Liborio Torregrossa, Fulvio Basolo, Elena Paltrinieri, Maria Chiara Zatelli, Gabriele Materazzi, Paolo Miccoli, Claudio Marcocci, Filomena Cetani