Article
Multidisciplinary Sciences
Ashish Saxena, Matthew S. Walters, Jae-Hung Shieh, Ling-Bo Shen, Kazunori Gomi, Robert J. Downey, Ronald G. Crystal, Malcolm A. S. Moore
Summary: The airway basal cells communicate with endothelial cells through exosome-enriched EVs, promoting cell survival via VEGFR2 activation and involvement of VEGFA. However, downstream signaling pathways involved in airway basal cell EVs may be distinct from other signaling pathways.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Takahiro Horinouchi, Soichi Miwa
Summary: This study compared the properties of mainstream smoke from heat-not-burn cigarettes and combustion cigarettes, finding that the cytotoxicity of heat-not-burn cigarette smoke was lower and exhibited inhibitory effects in human vascular endothelial cells.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Respiratory System
Qing Song, Ping Chen, Xiang-Ming Liu
Summary: COPD is a common chronic respiratory disease with smoking as a main risk factor. Recent research indicates that pulmonary vascular endothelial cell apoptosis plays a role in the pathogenesis of COPD.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Hongmei Tang, Yun Zhang, Qiao Wang, Ziling Zeng, Xiaoyun Wang, Yuejiao Li, Zhibin Wang, Ning Ma, Guofeng Xu, Xiaolin Zhong, Linlin Guo, Xiefang Yuan, Xing Wang
Summary: This study found that astaxanthin can attenuate DNA damage and apoptosis caused by cigarette smoke, and reduce the activation of Caspase-3. Astaxanthin can also decrease the production of intracellular reactive oxygen species by suppressing the expression of NOX4 and DUOX1.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Substance Abuse
Guibin Liang, Zhihui He, Huaihuai Peng, Menghao Zeng, Xuefeng Zhang
Summary: This study found that cigarette smoke extract can promote the apoptosis and senescence of EPCs by upregulating the expression of p300, thereby inhibiting the transition of EPCs from the G1 phase to the S phase, affecting telomerase synthesis, and reducing EPCs proliferation.
TOBACCO INDUCED DISEASES
(2023)
Article
Integrative & Complementary Medicine
Kenta Murata, Nina Fujita, Ryuji Takahashi
Summary: This study found that NYT can alleviate cigarette smoke-induced cell injury and inflammation by inhibiting the JNK signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Cell Biology
Jing Zhao, Haibo Xia, Yan Wu, Lu Lu, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Liu
Summary: Cigarette smoke is a main risk factor for emphysema, and a recent study found that circular RNA can regulate cigarette smoke-induced autophagy and apoptosis in alveolar epithelial cells by inhibiting miRNA. This discovery provides new insights and information for the diagnosis and treatment of emphysema.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Immunology
Lijing Wang, Qiong Chen, Qiao Yu, Jian Xiao, Hongjun Zhao
Summary: In this study, it was found that exosomes derived from cigarette smoke extract-treated mouse airway epithelial cells promoted M1 macrophage polarization by upregulating TREM-1 expression, thereby aggravating the development of COPD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Environmental Sciences
Jung-Min Park, Haerin Jeong, Yoon-Seok Seo, Van Quan Do, Seong-Jin Choi, Kyuhong Lee, Kyung-Chul Choi, Won Jun Choi, Moo-Yeol Lee
Summary: The presence of bicarbonate in the experimental conditions influences the superoxide generation induced by cigarette smoke, with peroxidase treatment reducing more than half of the superoxide production. This suggests that peroxides and peroxy acids are the main contributors to superoxide production in this process.
Article
Immunology
Yuqiang Pei, Jing Zhang, Jingge Qu, Yafei Rao, Danyang Li, Xiaoyan Gai, Yahong Chen, Ying Liang, Yongchang Sun
Summary: C3 is a pivotal element in the complement system and plays a critical role in the pathogenesis of COPD. CSE induces the expression of C3 in airway epithelial cells and C3 knockdown exacerbates oxidative stress and apoptosis caused by CSE, revealing a potential mechanism of C3 in COPD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Bangrong Cai, Mengya Liu, Jinxing Li, Dujuan Xu, Jiansheng Li
Summary: Overall, this study found that cigarette smoke extract (CSE) could oxidize PTEN in BEAS-2B cells, mainly through ROS from DUOX1 and 2 of NADPH oxidases leading to oxidative inactivation of PTEN and Trx-1, resulting in Akt activation and potentially contributing to the development of COPD. This suggests that PTEN could be a potential target for new therapies in COPD treatment.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Meng-Yu Zhang, Ying-Xiao Jiang, Yi-Can Yang, Jian-Yu Liu, Chen Huo, Xiu-Li Ji, Yi-Qing Qu
Summary: The study found that cigarette smoke induces inflammation and promotes pyroptosis in 16HBE cells through the ROS/NLRP3/caspase-1 pathway.
Article
Biochemistry & Molecular Biology
Ignazio Restivo, Alessandro Attanzio, Ilenia Concetta Giardina, Francesca Di Gaudio, Luisa Tesoriere, Mario Allegra
Summary: Research shows that exposure to cigarette smoke can induce apoptosis in red blood cells, involving the initiation of DISC formation by p38 MAPK and activation of caspase-8/caspase-3 through ceramide generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yuting Cui, Yingmin Liang, Mary S. M. Ip, Judith C. W. Mak
Summary: TSPO is closely associated with mitochondrial permeability transition pore (mPTP) and apoptosis in lung epithelium. Cigarette smoke medium induces apoptosis and TSPO plays a crucial role in regulating mitochondrial dysfunction. Targeting TSPO with specific antagonists may be beneficial in combating smoking-related diseases like COPD.
Article
Plant Sciences
Fang Cao, Kai-Rong Qin, Kai Kang, Guoshuang Zheng, Weidan Wang, Xiuzhi Zhang, Dewei Zhao
Summary: Ginkgo biloba L. extract (EGb) has been widely used for its diverse pharmacological properties. This study aimed to investigate the effect and mechanism of EGb in preventing steroid-induced necrosis of the femoral head (SINFH).
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Min Yang, Ping Chen, Hong Peng, Hongliang Zhang, Yan Chen, Shan Cai, Qianjin Lu, Chaxiang Guan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2015)
Article
Cell Biology
Yong Zhou, Guo-Ying Sun, Tian Liu, Jia-Xi Duan, Hui-Fang Zhou, Kin Sing Lee, Bruce D. Hammock, Xiang Fang, Jian-Xin Jiang, Cha-Xiang Guan
CELL AND TISSUE RESEARCH
(2016)
Article
Pathology
Wen-Zhuo Ran, Liang Dong, Chun-Yan Tang, Yong Zhou, Guo-Ying Sun, Tian Liu, Yong-Ping Liu, Cha-Xiang Guan
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2015)
Article
Infectious Diseases
Yan Qiu, Yansen Wang, Nan Lin, Mingxiang Huang, Yunhong Tan, Qing Wang, Yi Jiang, Haican Liu, Jiao Liu, Jingrui Zhang, Jue Wang, Xinchan Chen, Dongping Wang, Guilian Li, Zhongnan Chen, Lishui Zhang, Dixun Bao, Lili Zhao, Chaxiang Guan, Kanlgin Wan
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Pharmacology & Pharmacy
Hong-Xia Pei, Rong Hua, Cha-Xiang Guan, Xiang Fang
Letter
Biology
Deng Luo, Wenzhuo Ran, Gongfang Zhao, Chaxiang Guan, Chen Wang, Weiping Jia
SCIENCE CHINA-LIFE SCIENCES
(2016)
Correction
Cell Biology
Yong Zhou, Jun Yang, Guo-Ying Sun, Tian Liu, Jia-Xi Duan, Hui-Fang Zhou, Kin Sing Lee, Bruce D. Hammock, Xiang Fang, Jian-Xin Jiang, Cha-Xiang Guan
CELL AND TISSUE RESEARCH
(2016)
Article
Cell Biology
Liang Dong, Yong Zhou, Zhao-Qiong Zhu, Tian Liu, Jia-Xi Duan, Jun Zhang, Ping Li, Bruce D. Hammcok, Cha-Xiang Guan
Article
Multidisciplinary Sciences
Tian Liu, Yong Zhou, Ping Li, Jia-Xi Duan, Yong-Ping Liu, Guo-Ying Sun, Li Wan, Liang Dong, Xiang Fang, Jian-Xin Jiang, Cha-Xiang Guan
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Li Peng, Yong Zhou, Liang Dong, Rui-Qi Chen, Guo-Ying Sun, Tian Liu, Wen-Zhuo Ran, Xiang Fang, Jian-Xin Jiang, Cha-Xiang Guan
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Yong Zhou, Ping Li, Jia-Xi Duan, Tian Liu, Xin-Xin Guan, Wen-Xiu Mei, Yong-Ping Liu, Guo-Ying Sun, Li Wan, Wen-Jing Zhong, Dong-Sheng Ouyang, Cha-Xiang Guan
Article
Critical Care Medicine
Yong Zhou, Tian Liu, Jia-Xi Duan, Ping Li, Guo-Ying Sun, Yong-Ping Liu, Jun Zhang, Liang Dong, Kin Sing Stephen Lee, Bruce D. Hammock, Jian-Xin Jiang, Cha-Xiang Guan
Article
Respiratory System
Zhihui Shi, Yan Chen, Jun Cao, Huihui Zeng, Yue Yang, Ping Chen, Hong Luo, Hong Peng, Shan Cai, Chaxiang Guan
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2017)
Article
Biochemistry & Molecular Biology
Guo-Ying Sun, Hui-Hui Yang, Xin-Xin Guan, Wen-Jing Zhong, Yong-Ping Liu, Ming-Yuan Du, Xiao-Qin Luo, Yong Zhou, Cha-Xiang Guan
MOLECULAR IMMUNOLOGY
(2018)
Article
Oncology
Yan Qiu, Li Wan, Haican Liu, Kanglin Wan, Chaxiang Guan, Yi Jiang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2015)