Bioactive oligosaccharide natural products

Moenomycin Resistance Mutations in Staphylococcus aureus Reduce Peptidoglycan Chain Length and Cause Aberrant Cell Division

(2013) Yuriy Rebets et al.   ACS Chemical Biology

Tuning the Moenomycin Pharmacophore To Enable Discovery of Bacterial Cell Wall Synthesis Inhibitors

(2013) Christian M. Gampe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insights into the Mechanism of the Antibiotic-Synthesizing Enzyme MoeO5 from Crystal Structures of Different Complexes

(2012) Feifei Ren et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ABC transporter genes from Streptomyces ghanaensis moenomycin biosynthetic gene cluster: roles in antibiotic production and export

(2012) Bohdan Ostash et al.   ARCHIVES OF MICROBIOLOGY

Discovery of nosokophic acid, a predicted intermediate of moenomycins, from nosokomycin-producing Streptomyces sp. K04-0144

(2012) Nobuhiro Koyama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae

(2012) Tina Strobel et al.   BMC GENOMICS

Draft genome sequence of Streptomyces coelicoflavus ZG0656 reveals the putative biosynthetic gene cluster of acarviostatin family α-amylase inhibitors

(2012) X. Guo et al.   LETTERS IN APPLIED MICROBIOLOGY

The structural biology of enzymes involved in natural product glycosylation

(2012) Shanteri Singh et al.   NATURAL PRODUCT REPORTS

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of Staphylococcus aureus transglycosylase in complex with a lipid II analog and elucidation of peptidoglycan synthesis mechanism

(2012) C.-Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Streptomyces ghanaensis pleiotropic regulatory gene wblA gh influences morphogenesis and moenomycin production

(2011) Mariia Rabyk et al.   BIOTECHNOLOGY LETTERS

Differential Effects of Thiopeptide and Orthosomycin Antibiotics on Translational GTPases

(2011) Aleksandra Mikolajka et al.   CHEMISTRY & BIOLOGY

Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics

(2011) Christian M. Gampe et al.   TETRAHEDRON

Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin

(2010) Shinichiro Fuse et al.   ACS Chemical Biology

Structure and Mechanism of ORF36, an Amino Sugar Oxidizing Enzyme in Everninomicin Biosynthesis,

(2010) Jessica L. Vey et al.   BIOCHEMISTRY

High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase

(2010) Ting-Jen Rachel Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. II: Structure elucidation

(2010) Ryuji Uchida et al.   JOURNAL OF ANTIBIOTICS

Nosokomycins, new antibiotics discovered in an in vivo-mimic infection model using silkworm larvae. I: Fermentation, isolation and biological properties

(2010) Ryuji Uchida et al.   JOURNAL OF ANTIBIOTICS

Genetic factors that influence moenomycin production in streptomycetes

(2010) Roman Makitrynskyy et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Structures of human pancreatic α-amylase in complex with acarviostatins: Implications for drug design against type II diabetes

(2010) Xiaohong Qin et al.   JOURNAL OF STRUCTURAL BIOLOGY

Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity

(2010) Bohdan Ostash et al.   NATURAL PRODUCT REPORTS

Complete Characterization of the Seventeen Step Moenomycin Biosynthetic Pathway

(2009) Bohdan Ostash et al.   BIOCHEMISTRY

Biosynthetic genes for aminoglycoside antibiotics

(2009) Fumitaka Kudo et al.   JOURNAL OF ANTIBIOTICS

Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin

(2009) Holly Heaslet et al.   JOURNAL OF STRUCTURAL BIOLOGY

Brønsted Acid-Promoted Glycosylations of Disaccharide Glycal Substructures of the Saccharomicins

(2009) Bradley R. Balthaser et al.   ORGANIC LETTERS

Structural Analysis of the Contacts Anchoring Moenomycin to Peptidoglycan Glycosyltransferases and Implications for Antibiotic Design

(2008) Yanqiu Yuan et al.   ACS Chemical Biology

Profiling of Acarviostatin Family Secondary Metabolites Secreted byStreptomyces coelicoflavusZG0656 Using Ultraperformance Liquid Chromatography Coupled with Electrospray Ionization Mass Spectrometry

(2008) Peng Geng et al.   ANALYTICAL CHEMISTRY

Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification

(2008) Christopher J. Thibodeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of α-amylase

(2008) Peng Geng et al.   CARBOHYDRATE RESEARCH

Taxonomy of theStreptomycesstrain ZG0656 that produces acarviostatin α-amylase inhibitors and analysis of their effects on blood glucose levels in mammalian systems

(2008) P. Geng et al.   JOURNAL OF APPLIED MICROBIOLOGY

The gac-gene cluster for the production of acarbose from Streptomyces glaucescens GLA.O—Identification, isolation and characterization

(2008) Yvonne Rockser et al.   JOURNAL OF BIOTECHNOLOGY

A Unifying Nitrososynthase Involved in Nitrosugar Biosynthesis

(2008) Yunfeng Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics

(2008) T.-J. R. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two novel aminooligosaccharides isolated from the culture of Streptomyces coelicoflavus ZG0656 as potent inhibitors of α-amylase

(2007) Peng Geng et al.   CARBOHYDRATE RESEARCH