Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis

Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2

(2012) Akihiko Nishikimi et al.   CHEMISTRY & BIOLOGY

A Three-Gene Model to Robustly Identify Breast Cancer Molecular Subtypes

(2012) Benjamin Haibe-Kains et al.   JNCI-Journal of the National Cancer Institute

Strategies for the discovery and development of therapies for metastatic breast cancer

(2012) Bedrich L. Eckhardt et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

(2012) H. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation

(2011) Jennifer F. Raven et al.   CELL CYCLE

ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells

(2011) Shyamal D Desai et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

(2011) Haizhong Feng et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon-β Signaling Contributes to Ras Transformation

(2011) Yu-Chen Tsai et al.   PLoS One

DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4

(2010) Fumiyuki Sanematsu et al.   CIRCULATION RESEARCH

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

 1-integrin is dispensable for the induction of ErbB2 mammary tumors but plays a critical role in the metastatic phase of tumor progression

(2010) L. Huck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Stat3-Dependent Transcription Regulatory Network Involved in Metastatic Progression

(2009) J. J. Ranger et al.   CANCER RESEARCH

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement

(2008) Victoria Sanz-Moreno et al.   CELL

ShcA signalling is essential for tumour progression in mouse models of human breast cancer

(2008) Josie Ursini-Siegel et al.   EMBO JOURNAL

Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice

(2008) K. Strumane et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

uPAR promotes formation of the p130Cas–Crk complex to activate Rac through DOCK180

(2008) Harvey W. Smith et al.   JOURNAL OF CELL BIOLOGY

Signaling through ShcA Is Required for Transforming Growth Factor  - and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion

(2008) J. J. Northey et al.   MOLECULAR AND CELLULAR BIOLOGY