EKLF/KLF1, a Tissue-Restricted Integrator of Transcriptional Control, Chromatin Remodeling, and Lineage Determination

Inhibition of erythropoiesis by Smad6 in human cord blood hematopoietic stem cells

(2012) Young-Ju Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tissue-Restricted Transcription from a Conserved Intragenic CpG Island in the Klf1 Gene in Mice1

(2012) Cherie M. Southwood et al.   BIOLOGY OF REPRODUCTION

Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis

(2012) L. C. Dore et al.   BLOOD

Characterization of the transcriptome profiles related to globin gene switching during in vitro erythroid maturation

(2012) Biaoru Li et al.   BMC GENOMICS

Systematic Functional Prioritization of Protein Posttranslational Modifications

(2012) Pedro Beltrao et al.   CELL

Tissue-Specific Mitotic Bookmarking by Hematopoietic Transcription Factor GATA1

(2012) Stephan Kadauke et al.   CELL

Blood group phenotypes resulting from mutations in erythroid transcription factors

(2012) Belinda K. Singleton et al.   CURRENT OPINION IN HEMATOLOGY

Novel roles for KLF1 in erythropoiesis revealed by mRNA-seq

(2012) M. R. Tallack et al.   GENOME RESEARCH

Functional Interactions between Erythroid Kruppel-like Factor (EKLF/KLF1) and Protein Phosphatase PPM1B/PP2Cβ

(2012) Yvette Y. Yien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kruppel-Like Factor 1 (KLF1), KLF2, and Myc Control a Regulatory Network Essential for Embryonic Erythropoiesis

(2012) C. J. Pang et al.   MOLECULAR AND CELLULAR BIOLOGY

The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo

(2012) A. P. W. Funnell et al.   MOLECULAR AND CELLULAR BIOLOGY

A High-Throughput Chromatin Immunoprecipitation Approach Reveals Principles of Dynamic Gene Regulation in Mammals

(2012) Manuel Garber et al.   MOLECULAR CELL

Regulation of Delta-Aminolevulinic Acid Dehydratase by Krüppel-Like Factor 1

(2012) Aurelie D. Desgardin et al.   PLoS One

A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation

(2012) S. N. Wontakal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The multifunctional role of EKLF/KLF1 during erythropoiesis

(2011) M. Siatecka et al.   BLOOD

Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes

(2011) B. K. Singleton et al.   BLOOD

A transient definitive erythroid lineage with unique regulation of the  -globin locus in the mammalian embryo

(2011) K. E. McGrath et al.   BLOOD

Genome-wide ChIP-Seq reveals a dramatic shift in the binding of the transcription factor erythroid Kruppel-like factor during erythrocyte differentiation

(2011) A. M. Pilon et al.   BLOOD

Transcription factor networks in erythroid cell and megakaryocyte development

(2011) L. C. Dore et al.   BLOOD

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

(2011) Noa Novershtern et al.   CELL

Dynamic long-range chromatin interactions controlMybproto-oncogene transcription during erythroid development

(2011) Ralph Stadhouders et al.   EMBO JOURNAL

Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults

(2011) A. E. Gallienne et al.   HAEMATOLOGICA

Erythroid phenotypes associated with KLF1 mutations

(2011) J. Borg et al.   HAEMATOLOGICA

Relocalizing Genetic Loci into Specific Subnuclear Neighborhoods

(2011) Hsiang-Ying Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factors KLF1 and KLF2 Positively Regulate Embryonic and Fetal β-Globin Genes through Direct Promoter Binding

(2011) Yousef N. Alhashem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ultrastructural study of transcription factories in mouse erythroblasts

(2011) C. H. Eskiw et al.   JOURNAL OF CELL SCIENCE

Klf1 Affects DNase II-Alpha Expression in the Central Macrophage of a Fetal Liver Erythroblastic Island: a Non-Cell-Autonomous Role in Definitive Erythropoiesis

(2011) S. Porcu et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach

(2011) Belinda Giardine et al.   NATURE GENETICS

Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)

(2011) C. Mas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Dominant Mutation in the Gene Encoding the Erythroid Transcription Factor KLF1 Causes a Congenital Dyserythropoietic Anemia

(2010) Lionel Arnaud et al.   AMERICAN JOURNAL OF HUMAN GENETICS

c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

(2010) E. Bianchi et al.   BLOOD

Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf

(2010) J. Isern et al.   BLOOD

Multiple functions of Ldb1 required for  -globin activation during erythroid differentiation

(2010) S.-H. Song et al.   BLOOD

An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

(2010) Timothy Ravasi et al.   CELL

CYCLINg through transcription: Post-translational modifications of P-TEFb regulate transcription elongation

(2010) Sungyoo Cho et al.   CELL CYCLE

Update on fetal hemoglobin gene regulation in hemoglobinopathies

(2010) Daniel E Bauer et al.   CURRENT OPINION IN PEDIATRICS

A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells

(2010) M. R. Tallack et al.   GENOME RESEARCH

Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model

(2010) Daniel P. Heruth et al.   GENOMICS

KLF1 directly coordinates almost all aspects of terminal erythroid differentiation

(2010) Michael R. Tallack et al.   IUBMB LIFE

USF and NF-E2 Cooperate to Regulate the Recruitment and Activity of RNA Polymerase II in the β-Globin Gene Locus

(2010) Zhuo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GATA Switches as Developmental Drivers

(2010) Emery H. Bresnick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EKLF Directly Activates the p21 WAF1/CIP1 Gene by Proximal Promoter and Novel Intronic Regulatory Regions during Erythroid Differentiation

(2010) Miroslawa Siatecka et al.   MOLECULAR AND CELLULAR BIOLOGY

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

(2010) Joseph Borg et al.   NATURE GENETICS

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

(2010) Dewang Zhou et al.   NATURE GENETICS

Putting a finger on the switch

(2010) James J Bieker   NATURE GENETICS

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor

(2010) M. Siatecka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan)

(2009) Robert A. White et al.   BLOOD CELLS MOLECULES AND DISEASES

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

Promoting developmental transcription

(2009) U. Ohler et al.   DEVELOPMENT

Erythroid Kruppel-like factor (EKLF) is recruited to theγ-globingene promoter as a co-activator and is required forγ-globingene induction by short-chain fatty acid derivatives

(2009) Susan P. Perrine et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Discovering Hematopoietic Mechanisms through Genome-wide Analysis of GATA Factor Chromatin Occupancy

(2009) Tohru Fujiwara et al.   MOLECULAR CELL

Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis

(2009) Ming Yu et al.   MOLECULAR CELL

Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells

(2009) Stefan Schoenfelder et al.   NATURE GENETICS

BRG1 directly regulates nucleosome structure and chromatin looping of the α globin locus to activate transcription

(2009) Shin-Il Kim et al.   NUCLEIC ACIDS RESEARCH

Distinct modes of gene regulation by a cell-specific transcriptional activator

(2009) T. Sengupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype

(2008) B. K. Singleton et al.   BLOOD

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment

(2008) F. Lohmann et al.   DEVELOPMENT

Non-random subcellular distribution of variant EKLF in erythroid cells

(2008) Karen J. Quadrini et al.   EXPERIMENTAL CELL RESEARCH

Transcription factories are nuclear subcompartments that remain in the absence of transcription

(2008) J. A. Mitchell et al.   GENES & DEVELOPMENT

A Network of Krüppel-like Factors (Klfs)

(2008) Sally A. Eaton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetylation of EKLF Is Essential for Epigenetic Modification and Transcriptional Activation of the  -Globin Locus

(2008) T. Sengupta et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of ZBP-89 as a Novel GATA-1-Associated Transcription Factor Involved in Megakaryocytic and Erythroid Development

(2008) A. J. Woo et al.   MOLECULAR AND CELLULAR BIOLOGY

Failure of Terminal Erythroid Differentiation in EKLF-Deficient Mice Is Associated with Cell Cycle Perturbation and Reduced Expression of E2F2

(2008) A. M. Pilon et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of SUMO-Dependent Chromatin-Associated Transcriptional Repression Components by a Genome-wide RNAi Screen

(2008) Bastian Stielow et al.   MOLECULAR CELL

Maintenance of Long-Range DNA Interactions after Inhibition of Ongoing RNA Polymerase II Transcription

(2008) Robert-Jan Palstra et al.   PLoS One