Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Simona Granata, Valentina Votrico, Federica Spadaccino, Valeria Catalano, Giuseppe Stefano Netti, Elena Ranieri, Giovanni Stallone, Gianluigi Zaza
Summary: Although there have been advances in kidney transplant medicine, patients may still experience complications after transplantation. Ischemia/reperfusion injury plays a major role in these complications, leading to delayed graft function and potential kidney damage. Understanding the pathways involved, such as ferroptosis and mitophagy, could aid in the development of noninvasive diagnostic biomarkers and pharmacological strategies for these complications.
Article
Biochemistry & Molecular Biology
Chih-Chao Yang, Pei-Hsun Sung, John Y. Chiang, Han-Tan Chai, Chih-Hung Chen, Yi-Ching Chu, Yi-Chen Li, Hon-Kan Yip
Summary: Combined tacrolimus and melatonin therapy was more effective than either single treatment in protecting the kidney from IR injury by suppressing inflammation and oxidative stress.
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Article
Biochemistry & Molecular Biology
Nora A. Spraakman, Annemieke M. Coester, Arno R. Bourgonje, Vincent B. Nieuwenhuijs, Jan-Stephan F. Sanders, Henri G. D. Leuvenink, Harry van Goor, Gertrude J. Nieuwenhuijs-Moeke
Summary: In this study, the researchers investigated the changes in R-SH levels during kidney transplantation and found that renal ischemia-reperfusion injury can result in trans-renal oxidative stress. The levels of R-SH in systemic and renal samples of transplant recipients were found to reflect the graft function changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Huaying Wang, Shanshan Guo, Bingdian Wang, Xueqi Liu, Li Gao, Chaoyi Chen, Yonggui Wu
Summary: The study found that carnosine can alleviate acute kidney injury, inflammation and ferroptosis. Treatment with carnosine reduced lipid peroxidation and iron accumulation, suppressed oxidative stress, and inhibited ferroptosis. Furthermore, carnosine was shown to bind with GPX4, which is a potential target for its protective effects on kidney cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Transplantation
Meiwen Ding, Evelyn Tolbert, Mark Birkenbach, Fatemeh Akhlaghi, Reginald Gohh, Nisanne S. Ghonem
Summary: This study demonstrated that treprostinil effectively ameliorated I/R-induced AKI in rats by improving renal function early post-reperfusion, inhibiting renal inflammation, and preventing tubular epithelial apoptosis. These findings suggest that treprostinil could serve as a potential therapeutic agent for protecting the kidney against IRI in vivo.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Charith U. B. Wijerathne, Kathy K. W. Au-Yeung, Yaw L. Siow, O. Karmin
Summary: Oxidative stress is a major factor in adverse outcomes of acute kidney injury, and deficiency in micronutrients is common in this condition. This study found that 5-MTHF can improve kidney function by activating Nrf2 and restoring antioxidant defense, thereby reducing oxidative stress.
Article
Biochemistry & Molecular Biology
Anna Radajewska, Jakub Szyller, Anna Krzywonos-Zawadzka, Agnieszka Olejnik, Grzegorz Sawicki, Iwona Bil-Lula
Summary: Transplanted organs are exposed to harmful conditions before and after surgery. Adding the antioxidant MitoQ to the hypothermic machine perfusion system can mitigate kidney injury and improve transplantation success rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyun Seok Hwang, Aida Rahimi Kahmini, Julia Prascak, Alexis Cejas-Carbonell, Isela C. Valera, Samantha Champion, Mikayla Corrigan, Florence Mumbi, Michelle S. Parvatiyar
Summary: This study investigated the role of sarcospan (SSPN) in the cardiac response to acute ischemia-reperfusion (IR) injury. The findings suggested that SSPN deficiency in mice leads to increased infarct size and arrhythmia susceptibility post-IR injury. Additionally, SSPN depletion resulted in decreased Ca2+ handling capacity and increased oxidative stress pathways in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
M. Watanabe, F. T. Borges, E. A. Pessoa, C. D. Fonseca, S. M. Fernandes, R. C. Drew, R. A. Volpini, M. F. F. Vattimo
Summary: The study investigated the protective effect of N-acetylcysteine (NAC) in short-term and long-term ischemic acute kidney injury, showing antioxidant effects of NAC in short-term ischemia but not in long-term ischemia, suggesting the existence of a therapeutic window for its renoprotective effect.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Changjiang Gu, Fanqi Kong, Junkai Zeng, Xiangwu Geng, Yanqing Sun, Xiongsheng Chen
Summary: Delayed remote ischemic preconditioning (RIPC) has protective effects against spinal cord ischemia-reperfusion injury (SCIRI) in mice, and SIRT3 is involved in this protection through the NMDAR-AMPK-PGC-1 alpha signaling pathway.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dandan Xing, QiuChang Li, Guanwen Lin, Hui Lin, Wenyue Kang, Min Zhang, Rong Ding, Na Li
Summary: This study demonstrated that NOR has protective effects against I/R-induced renal injury, enhancing the nephroprotective effects of propofol, and reducing levels of creatinine and blood urea nitrogen. Treatment with propofol or NOR, alone and in combination, also decreased cytokine and oxidative stress levels in rats with kidney injury.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyeonbin Shin, Seungwon Jeong, Yeongjong Lee, Chanhee Jeon, Gayoung Kwon, Sooyeon Kim, Dongwon Lee
Summary: Renal ischemia-reperfusion (IR) injury is a common complication in clinical settings and currently lacks effective treatment. This study developed a novel nanoparticle drug that can protect the kidneys from IR injury by eliminating hydrogen peroxide (H2O2), exerting anti-inflammatory and anti-apoptotic effects. These nanoparticles have potential therapeutic value not only for renal IR injury but also for other inflammatory diseases associated with reactive oxygen species (ROS).
Article
Medicine, Research & Experimental
Ken-Ichiro Tanaka, Mikako Shimoda, Maho Kubota, Ayaka Takafuji, Masahiro Kawahara, Tohru Mizushima
Summary: Lecithinized superoxide dismutase (PCSOD) effectively ameliorates renal ischemia/reperfusion (I/R) injury by inhibiting ROS production, reducing markers of renal damage and fibrosis, and preventing the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). This suggests that PCSOD could be a promising therapeutic agent for I/R-induced renal injury.
Article
Materials Science, Multidisciplinary
Pardeep Kaur, K. J. Singh, Sandeep Kaur, Satwinderjeet Kaur, Amrit Pal Singh
MATERIALS CHEMISTRY AND PHYSICS
(2020)
Article
Pharmacology & Pharmacy
Dilpreet Singh, Amrit Pal Singh, Drishtant Singh, Anup Kumar Kesavan, Ashok K. Tiwary, Neena Bedi
Summary: The study explores the enhanced biopharmaceutical attributes of solid supersaturable self-microemulsifying drug delivery system for the poorly water soluble drug canagliflozin. Results show promising potential in developing an effective formulation for diabetes mellitus.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Article
Chemistry, Medicinal
Tajpreet Kaur, Damanpreet Singh, Amrit P. Singh, Devendra Pathak, Saroj Arora, Brahmjot Singh, Sarabjit Kaur, Balbir Singh
Summary: This study demonstrated that stevioside can attenuate rhabdomyolysis-induced acute kidney injury, potentially through modulation of PPAR-gamma expression.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anudeep Kaur, Lovedeep Singh, Saweta Garg, Harmanpreet Kaur, Nirmal Singh, Rajbir Bhatti
Summary: Musculoskeletal pain is a complex global health concern that requires accurate diagnosis of biomarkers and mechanism-based therapeutic interventions. Heraclin treatment in an experimental mouse model showed beneficial effects against musculoskeletal pain disorder, possibly through attenuation of NGFR-mediated pain and inflammatory signaling.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lovedeep Singh, Anudeep Kaur, Saweta Garg, Amrit Pal Singh, Rajbir Bhatti
NEUROCHEMICAL RESEARCH
(2020)
Article
Environmental Sciences
Ashwani Kumar Sharma, Japneet Kaur, Tajpreet Kaur, Balbir Singh, Harlokesh Narayan Yadav, Devendra Pathak, Amrit Pal Singh
Summary: Arsenic exposure causes renal damage and oxidative stress in rats, which can be attenuated by bosentan treatment. Bosentan also restores renal eNOS expression and mitigates arsenic-induced hepatic changes in rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Medicinal
Jashanpreet Kaur, Tajpreet Kaur, Ashwani Kumar Sharma, Japneet Kaur, Harlokesh Narayan Yadav, Devendra Pathak, Amrit Pal Singh
Summary: Fenofibrate attenuates I/R-induced AKI and associated hepatic dysfunction potentially through modulation of eNOS expression.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Harpal Singh, Payal Bajaj, Shikha Kalotra, Anmol Bhandari, Taranjeet Kaur, Amrit Pal Singh, Gurcharan Kaur
Summary: The study demonstrated the potential of Tinospora cordifolia extract in mitigating anxiety, apoptosis, and neuroinflammation in high fat diet-induced obesity rat model. The extract showed modulation of inflammation, apoptosis, and synaptic plasticity in obese rats fed with high fat diet, suggesting its potential therapeutic value in managing obesity-related brain dysfunctions.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Ashwani Kumar Sharma, Anmoldeep Kaur, Tajpreet Kaur, Sarabjit Kaur, Devendra Pathak, Amrit Pal Singh
Summary: Arsenic exposure poses significant health risks, but iNOS inhibitors can alleviate arsenic-induced renal and hepatic dysfunction in rats.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sumedha Sharma, Tajpreet Kaur, Ashwani Kumar Sharma, Balbir Singh, Devendra Pathak, Harlokesh Narayan Yadav, Amrit Pal Singh
Summary: Betaine exhibits a protective role against sodium arsenite-induced renal dysfunction in rats, which is attributed to its antioxidant activity and modulation of renal eNOS expression.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Review
Chemistry, Medicinal
Anudeep Kaur, Rajbir Bhatti
Summary: Angelica archangelica, known as garden angelica, is a plant with diverse pharmacological potential, including anti-anxiety and antiviral activities. Its beneficial effects are attributed to its bioactive components, coumarins and volatile oils, making it a valuable subject for further research.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Ashwani Kumar Sharma, Anmoldeep Kaur, Japneet Kaur, Gurpreet Kaur, Apporva Chawla, Mannan Khanna, Harmanpreet Kaur, Harnoor Kaur, Tajpreet Kaur, Amrit Pal Singh
Summary: The study showed that DADS has a protective effect against glycerol-induced renal damage in rats, with PPAR-gamma playing a key role in mediating this renoprotective effect.
JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
(2021)