Molecular Architecture and Function of the SEA Complex, a Modulator of the TORC1 Pathway

The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila

(2014) Y Wei et al.   CELL DEATH AND DIFFERENTIATION

Vps1 in the late endosome-to-vacuole traffic

(2013) Jacob Hayden et al.   JOURNAL OF BIOSCIENCES

Mutations of DEPDC5 cause autosomal dominant focal epilepsies

(2013) Saeko Ishida et al.   NATURE GENETICS

Mutations in DEPDC5 cause familial focal epilepsy with variable foci

(2013) Leanne M Dibbens et al.   NATURE GENETICS

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1

(2013) N. Panchaud et al.   Science Signaling

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Early detection of neurodegenerative diseases

(2012) Kira S. Sheinerman et al.   CELL CYCLE

Structure–function mapping of a heptameric module in the nuclear pore complex

(2012) Javier Fernandez-Martinez et al.   JOURNAL OF CELL BIOLOGY

A Systematic Investigation into the Nature of Tryptic HCD Spectra

(2012) Annette Michalski et al.   JOURNAL OF PROTEOME RESEARCH

Nprl3 is required for normal development of the cardiovascular system

(2012) Monika S. Kowalczyk et al.   MAMMALIAN GENOME

Expanding the Chemical Cross-Linking Toolbox by the Use of Multiple Proteases and Enrichment by Size Exclusion Chromatography

(2012) Alexander Leitner et al.   MOLECULAR & CELLULAR PROTEOMICS

Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1

(2012) Lydie Michaillat et al.   MOLECULAR BIOLOGY OF THE CELL

Transient Sequestration of TORC1 into Stress Granules during Heat Stress

(2012) Terunao Takahara et al.   MOLECULAR CELL

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

(2012) F. Herzog et al.   SCIENCE

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

(2012) R. K. Nookala et al.   Open Biology

Putting the Pieces Together: Integrative Modeling Platform Software for Structure Determination of Macromolecular Assemblies

(2012) Daniel Russel et al.   PLOS BIOLOGY

Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

(2012) Dapeng Zhang et al.   Frontiers in Genetics

A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation

(2011) Svetlana Dokudovskaya et al.   Autophagy

The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis

(2011) S. Senger et al.   DEVELOPMENT

Mitochondria regulate autophagy by conserved signalling pathways

(2011) Martin Graef et al.   EMBO JOURNAL

Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control

(2011) Robbie Loewith et al.   GENETICS

On a bender—BARs, ESCRTs, COPs, and finally getting your coat

(2011) Mark C. Field et al.   JOURNAL OF CELL BIOLOGY

A Conserved Coatomer-related Complex Containing Sec13 and Seh1 Dynamically Associates With the Vacuole inSaccharomyces cerevisiae

(2011) Svetlana Dokudovskaya et al.   MOLECULAR & CELLULAR PROTEOMICS

Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation

(2011) Xi Wu et al.   MOLECULAR BIOLOGY OF THE CELL

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Structure of Coatomer Cage Proteins and the Relationship among COPI, COPII, and Clathrin Vesicle Coats

(2010) Changwook Lee et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry

(2010) Zhuo Angel Chen et al.   EMBO JOURNAL

Integrative Structure Modeling of Macromolecular Assemblies from Proteomics Data

(2010) Keren Lasker et al.   MOLECULAR & CELLULAR PROTEOMICS

Markov random fields reveal an N-terminal double beta-propeller motif as part of a bacterial hybrid two-component sensor system

(2010) M. Menke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determining macromolecular assembly structures by molecular docking and fitting into an electron density map

(2010) Keren Lasker et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The tumor suppressor NPRL2 in hepatocellular carcinoma plays an important role in progression and can be served as an independent prognostic factor

(2009) Satoshi Otani et al.   JOURNAL OF SURGICAL ONCOLOGY

Evidence for a Shared Nuclear Pore Complex Architecture That Is Conserved from the Last Common Eukaryotic Ancestor

(2009) Jeffrey A. DeGrasse et al.   MOLECULAR & CELLULAR PROTEOMICS

The Vam6 GEF Controls TORC1 by Activating the EGO Complex

(2009) Matteo Binda et al.   MOLECULAR CELL

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

(2009) Taavi K. Neklesa et al.   PLoS Genetics

TOR1 and TOR2 Have Distinct Locations in Live Cells

(2008) Thomas W. Sturgill et al.   EUKARYOTIC CELL

A Fence-like Coat for the Nuclear Pore Membrane

(2008) Erik W. Debler et al.   MOLECULAR CELL

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE