Article
Biochemistry & Molecular Biology
Chen Jin, Rui Li, Tuo Deng, Jialiang Li, Yan Yang, Haoqi Li, Kaiyu Chen, Huihua Xiong, Gang Chen, Yi Wang
Summary: This study investigated the role of m6A regulator-related lncRNA as a prognostic biomarker in patients with HCC. By constructing the prognostic signature m6A-9LPS, the prognosis of HCC patients could be accurately predicted, which can aid in personalized treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Jihao Cai, Minglei Zhou, Jianxin Xu
Summary: SNRPC is upregulated in hepatocellular carcinoma, associated with prognosis, and may impact the tumor microenvironment and immunotherapy efficacy.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Sabir Khan, Xueqi Xu, Jialei Song, Panpan Wu, Xiaobin Liu, Jing Liu, Ketao Chen, Zhenyue Xu, Hang Wu, Buchang Zhang
Summary: This study for the first time reported a NmrA homologue in actinomycetes that modulates antibiotic biosynthesis and nitrogen metabolism. Combinatorial engineering of SACE_4839 and nmrR significantly increased erythromycin production in S. erythraea WB.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Medical Laboratory Technology
Shuwei Wang, Shixiang Chen, Ming Jin, Mengyuan Hu, Weiguang Huang, Zhenluo Jiang, Jianuo Yang, Yecheng Zhang, Haoming Wu, Yaoren Hu, Weixin He, Liyun Fu
Summary: Serum CHI3L1 has significant diagnostic and prognostic value in hepatocellular carcinoma, and can serve as an independent prognostic factor.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Gastroenterology & Hepatology
Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Dong-Hwan Jung, Gil-Chun Park, Young-In Yoon, Sung-Gyu Lee
Summary: The study evaluated the prognostic impact of the ADV score for predicting HCC recurrence and patient survival after LDLT in 843 HCC patients. The ADV score showed a significant correlation with TR and OS, providing further prognostic stratification beyond existing criteria. Compared to pre-existing selection criteria, the ADV score with a cutoff of 5log exhibited the highest prognostic contrast for TR and OS, making it a valuable prognostic tool for posttransplant prognosis in HCC patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Afsoon Afshari, Ramin Yaghobi, Mohammad Hossein Karimi, Javad Mowla
Summary: The study identified specific miRNAs (such as hsa-miR-3158-5p, -4449, -194-5p, and -548as-3p) that were significantly correlated with the development of HCC in liver transplant patients. These miRNAs may serve as potential biomarkers for further studies.
BMC GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shuxian Zhang, Hanjuan Gong, Hailun Xie, Zhimin Huangfu, Yi Tang, Ming Xiao, Ming Li, Qingshu Li, Yalan Wang
Summary: In this study, the expression and clinical significance of DNM1L in hepatocellular carcinoma (HCC) were investigated. It was found that DNM1L expression was significantly higher in HCC tissues compared to adjacent/normal liver tissues. High DNM1L expression was associated with poorer overall survival and disease-free survival in HCC patients. Furthermore, DNM1L was found to be involved in key metabolic pathways and the resistance to sorafenib therapy, as well as the infiltration of immune cells in the tumor microenvironment.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Yimin Liang, Shijie Su, Zhaoxia Lun, Zishao Zhong, Weifeng Yu, Guihua He, Qi Wang, Jing Wang, Suiping Huang
Summary: Ferroptosis and the tumor microenvironment (TME) play crucial roles in the oncogenesis and progression of liver hepatocellular carcinoma (LIHC), and SLC7A11 can serve as a predictive biomarker for personalized immunotherapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Sawako Suzuki, Divya Venkatesh, Hiroaki Kanda, Akitoshi Nakayama, Hiroyuki Hosokawa, Eunyoung Lee, Takashi Miki, Brent R. Stockwell, Koutaro Yokote, Tomoaki Tanaka, Carol Prives
Summary: This study demonstrates that the key regulator of glutaminolysis, GLS2, can limit HCC in vivo by promoting ferroptosis through aKG-dependent lipid ROS, which in turn might lay the foundation for a novel therapeutic approach.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leyao Wang, Meng Liang, Bing Feng, Dengfeng Li, Rong Cong, Zhaowei Chen, Sicong Wang, Xiaohong Ma, Xinming Zhao
Summary: A model based on Gd-EOB-DTPA magnetic resonance imaging (MRI) was established to predict the prognosis of patients with MVI-negative HCC. The study found that lower RER, hepatobiliary phase hypointensity, LI-RADS category, mild-moderate T2 hyperintensity, and higher aspartate aminotransferase levels were risk factors associated with prognosis.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Wang Zhang, Yue Zhang, Yipeng Wan, Qi Liu, Xuan Zhu
Summary: This study developed a bile acid-related gene signature for hepatocellular carcinoma (HCC) patients, based on data from TCGA and ICGC databases. The signature demonstrated good predictive ability and discrimination in both cohorts, with high-risk patients showing increased immune checkpoint expression and low drug sensitivity. The findings suggest potential for individualized treatment and prognosis assessment in HCC.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Qianqian Wu, Sutian Jiang, Tong Cheng, Manyu Xu, Bing Lu
Summary: This study established a risk model incorporating two pyroptosis-related genes (PRGs) to predict the prognosis of hepatocellular carcinoma (HCC) patients. The model successfully classified patients into different risk groups and demonstrated its efficacy in predicting overall survival in both TCGA and ICGC datasets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Silvia Cagnin, Rossella Donghia, Andrea Martini, Pasqua Letizia Pesole, Sergio Coletta, Endrit Shahini, Giulia Boninsegna, Alessandra Biasiolo, Patrizia Pontisso, Gianluigi Giannelli
Summary: The GALAD score shows promise as a prognostic tool for hepatocellular carcinoma (HCC), with implications for improving patient management and treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Wen Ye, Zhehao Shi, Yilin Zhou, Zhongjing Zhang, Yi Zhou, Bicheng Chen, Qiyu Zhang
Summary: This study identified a panel of autophagy-related prognostic markers for liver cancer, which can be used to monitor the outcomes of patients. Furthermore, the study showed that FKBP1A is overexpressed in HCC and regulates cell proliferation, migration, and invasion through the PI3K/AKT/mTOR signaling pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xuyang Ma, Ying Ding, Li Zeng
Summary: In this study, it was found that H2AFY is significantly overexpressed in HCC and is positively correlated with clinical characteristics of HCC patients. H2AFY may serve as a potential diagnostic and prognostic marker for HCC, as high expression predicts a poor prognosis.