Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

p21-activated kinase 1: PAK’ed with potential

(2015) Christy Ong et al.   Oncotarget

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

p21-Activated kinase inhibitors: a patent review

(2012) James J Crawford et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct

(2012) Matthew Stokes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS

(2012) Matthew P. Stokes et al.   MOLECULAR & CELLULAR PROTEOMICS

Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling

(2012) H. Tabusa et al.   MOLECULAR CANCER RESEARCH

P21-activated kinase 4 (PAK4) is required for metaphase spindle positioning and anchoring

(2012) G Bompard et al.   ONCOGENE

Essential Role of Cdc42 in Ras-Induced Transformation Revealed by Gene Targeting

(2012) Kristy R. Stengel et al.   PLoS One

Cdc42 in oncogenic transformation, invasion, and tumorigenesis

(2011) Kristy Stengel et al.   CELLULAR SIGNALLING

Inhibition of Ras for cancer treatment: the search continues

(2011) Antonio T Baines et al.   Future Medicinal Chemistry

Phosphoproteomics Identifies Oncogenic Ras Signaling Targets and Their Involvement in Lung Adenocarcinomas

(2011) Putty-Reddy Sudhir et al.   PLoS One

Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP

(2011) Jawdat Al-Bassam et al.   TRENDS IN CELL BIOLOGY

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts

(2010) Daniel M Appledorn et al.   BMC CANCER

Copy number alterations in pancreatic cancer identify recurrentPAK4amplification

(2010) Shuaili Chen et al.   CANCER BIOLOGY & THERAPY

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Targeting the Mitogen-Activated Protein Kinase Pathway: Physiological Feedback and Drug Response

(2010) C. A. Pratilas et al.   CLINICAL CANCER RESEARCH

Signalling to cancer cell invasion through PAK family kinases

(2010) Andrew Whale   Frontiers in Bioscience-Landmark

The PI3K Pathway As Drug Target in Human Cancer

(2010) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

Compartmentalized Ras Proteins Transform NIH 3T3 Cells with Different Efficiencies

(2010) C.-M. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

(2010) A. Moritz et al.   Science Signaling

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Filamins in cell signaling, transcription and organ development

(2010) Alex-Xianghua Zhou et al.   TRENDS IN CELL BIOLOGY

Caenorhabditis elegansHas a Phosphoproteome Atypical for Metazoans That Is Enriched in Developmental and Sex Determination Proteins

(2009) Dorota F. Zielinska et al.   JOURNAL OF PROTEOME RESEARCH

Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer

(2009) Yang Liu et al.   LUNG CANCER

Pak4, a Novel Gab1 Binding Partner, Modulates Cell Migration and Invasion by the Met Receptor

(2009) G. N. Paliouras et al.   MOLECULAR AND CELLULAR BIOLOGY

FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST

(2009) Yanhua Zheng et al.   MOLECULAR CELL

Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling

(2009) Ramars Amanchy et al.   Molecular Oncology

High-accuracy identification and bioinformatic analysis ofin vivoprotein phosphorylation sites in yeast

(2009) Florian Gnad et al.   PROTEOMICS

The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

(2008) Y. Liu et al.   MOLECULAR CANCER RESEARCH

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

(2008) A. C. Kimmelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS

(2008) U. Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors

(2008) Cuiping Pan et al.   PROTEOMICS