Lysosomal metal, redox and proton cycles influencing the CysHis cathepsin reaction

Connecting Type 1 and Type 2 Diabetes through Innate Immunity

(2013) J. I. Odegaard et al.   Cold Spring Harbor Perspectives in Medicine

Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels

(2012) Rikki Chokshi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy in lysosomal storage disorders

(2012) Andrew P. Lieberman et al.   Autophagy

Vacuole–mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome–mitochondria-mediated apoptosis in mammals

(2012) Maria João Sousa et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The zinc homeostasis network of land plants

(2012) Scott Aleksander Sinclair et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Physiologic implications of metal-ion transport by ZIP14 and ZIP8

(2012) Supak Jenkitkasemwong et al.   BIOMETALS

Lysosome-Related Organelles in Intestinal Cells Are a Zinc Storage Site in C. elegans

(2012) Hyun Cheol Roh et al.   Cell Metabolism

Fluorescent Zinc Sensor with Minimized Proton-Induced Interferences: Photophysical Mechanism for Fluorescence Turn-On Response and Detection of Endogenous Free Zinc Ions

(2012) Ji Eon Kwon et al.   INORGANIC CHEMISTRY

Cathepsin S dominates autoantigen processing in human thymic dendritic cells

(2012) Christina Stoeckle et al.   JOURNAL OF AUTOIMMUNITY

Loss of Lysosomal Ion Channel Transient Receptor Potential Channel Mucolipin-1 (TRPML1) Leads to Cathepsin B-dependent Apoptosis

(2012) Grace A. Colletti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate Profile and Metal-ion Selectivity of Human Divalent Metal-ion Transporter-1

(2012) Anthony C. Illing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Balanced Ero1 activation and inactivation establishes ER redox homeostasis

(2012) Sunghwan Kim et al.   JOURNAL OF CELL BIOLOGY

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction,  -Synuclein Accumulation, and Neurotoxicity

(2012) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition

(2012) Daniel W. Nebert et al.   Metallomics

Two Plant Bacteria, S. meliloti and Ca. Liberibacter asiaticus, Share Functional znuABC Homologues That Encode for a High Affinity Zinc Uptake System

(2012) Cheryl M. Vahling-Armstrong et al.   PLoS One

Genetic Inhibition of Solute-Linked Carrier 39 Family Transporter 1 Ameliorates Aβ Pathology in a Drosophila Model of Alzheimer's Disease

(2012) Minglin Lang et al.   PLoS Genetics

Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron

(2011) Jorge J. Pinilla-Tenas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Biochemistry of Mobile Zinc and Nitric Oxide Revealed by Fluorescent Sensors

(2011) Michael D. Pluth et al.   Annual Review of Biochemistry

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Redox Control of the Ubiquitin-Proteasome System: From Molecular Mechanisms to Functional Significance

(2011) Franziska Kriegenburg et al.   ANTIOXIDANTS & REDOX SIGNALING

Crosstalk and Barriers Between the Electron Carriers of the Endoplasmic Reticulum

(2011) Gábor Bánhegyi et al.   ANTIOXIDANTS & REDOX SIGNALING

CUP-5, theC. elegansortholog of the mammalian lysosomal channel protein MLN1/TRPML1, is required for proteolytic degradation in autolysosomes

(2011) Tao Sun et al.   Autophagy

The over-expression of TRPC6 channels in HEK-293 cells favours the intracellular accumulation of zinc

(2011) Julien Gibon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Thioredoxin glutathione reductase: Its role in redox biology and potential as a target for drugs against neglected diseases

(2011) Stefanie Prast-Nielsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of thioredoxin in the regulation of cellular processes by S-nitrosylation

(2011) Rajib Sengupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The endosome–lysosome pathway and information generation in the immune system

(2011) Colin Watts   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The lysosomal polypeptide transporter TAPL: more than a housekeeping factor?

(2011) Irina Bangert et al.   BIOLOGICAL CHEMISTRY

Evidence of association with type 1 diabetes in the SLC11A1 gene region

(2011) Jennie HM Yang et al.   BMC Medical Genetics

TRPML: Transporters of metals in lysosomes essential for cell survival?

(2011) Kirill Kiselyov et al.   CELL CALCIUM

Unraveling the Biological Roles of Reactive Oxygen Species

(2011) Michael P. Murphy et al.   Cell Metabolism

Zinc(II) Complexes of Ubiquitin: Speciation, Affinity and Binding Features

(2011) Giuseppe Arena et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mapping the cysteine proteome: analysis of redox-sensing thiols

(2011) Dean P Jones et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Cystatins, Serpins and other Families of Protease Inhibitors in Plants

(2011) Mariateresa Volpicella et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Monomethylarsenic Diglutathione Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1)

(2011) M. W. Carew et al.   DRUG METABOLISM AND DISPOSITION

Phagosomal proteolysis in dendritic cells is modulated by NADPH oxidase in a pH-independent manner

(2011) Joanna M Rybicka et al.   EMBO JOURNAL

Reversible and irreversible protein glutathionylation: biological and clinical aspects

(2011) Arthur JL Cooper et al.   Expert Opinion on Drug Metabolism & Toxicology

A polymorphism of the interferon-gamma-inducible protein 30 gene is associated with hyperglycemia in severely obese individuals

(2011) V. Turcot et al.   HUMAN GENETICS

Mucolipin-3 Regulates Luminal Calcium, Acidification, and Membrane Fusion in the Endosomal Pathway

(2011) Benjamin Lelouvier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Inactivates Melastatin Transient Receptor Potential 2 Channels via the Outer Pore

(2011) Wei Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Melastatin 1 (TRPM1) Is an Ion-conducting Plasma Membrane Channel Inhibited by Zinc Ions

(2011) Sachar Lambert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox biochemistry of mammalian metallothioneins

(2011) Wolfgang Maret   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV

(2011) S. Vergarajauregui et al.   JOURNAL OF CELL SCIENCE

Lysosomal pH and analysis of the counter ion pathways that support acidification

(2011) Jessica E. DiCiccio et al.   JOURNAL OF GENERAL PHYSIOLOGY

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

(2011) K. Niemi et al.   JOURNAL OF IMMUNOLOGY

Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells

(2011) Leslie C. Costello et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Arsenic–glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs)

(2011) Elaine M. Leslie   JOURNAL OF INORGANIC BIOCHEMISTRY

New perspectives of zinc coordination environments in proteins

(2011) Wolfgang Maret   JOURNAL OF INORGANIC BIOCHEMISTRY

The “magic numbers” of metallothionein

(2011) Duncan E. K. Sutherland et al.   Metallomics

Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence

(2011) Joshua S. Klein et al.   Metallomics

Molecular and genetic features of zinc transporters in physiology and pathogenesis

(2011) Toshiyuki Fukada et al.   Metallomics

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Role of TRP Channels in the Regulation of the Endosomal Pathway

(2011) Ken Abe et al.   PHYSIOLOGY

Repurposing lipoic acid changes electron flow in two important metabolic pathways of Escherichia coli

(2011) M. A. Feeney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple ways to make disulfides

(2011) Neil J. Bulleid et al.   TRENDS IN BIOCHEMICAL SCIENCES

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Molecular Mechanisms Regulating Oxidative Activity of the Ero1 Family in the Endoplasmic Reticulum

(2010) Timothy J. Tavender et al.   ANTIOXIDANTS & REDOX SIGNALING

A role for chloride transport in lysosomal protein degradation

(2010) Lena Wartosch et al.   Autophagy

Interaction of calcium with the human divalent metal-ion transporter-1

(2010) Ali Shawki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of Surface-Exposed Reactive Cysteine Residues inSaccharomyces cerevisiae

(2010) Stefano M. Marino et al.   BIOCHEMISTRY

Regulation and Isoform Function of the V-ATPases

(2010) Masashi Toei et al.   BIOCHEMISTRY

Impaired turnover of autophagolysosomes in cathepsin L deficiency

(2010) Julia Dennemärker et al.   BIOLOGICAL CHEMISTRY

Heavy metal cations permeate the TRPV6 epithelial cation channel

(2010) Gergely Kovacs et al.   CELL CALCIUM

Formation, Reactivity, and Detection of Protein Sulfenic Acids

(2010) Nicholas J. Kettenhofen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MRP proteins as potential mediators of heavy metal resistance in zebrafish cells

(2010) Yong Long et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Imaging mobile zinc in biology

(2010) Elisa Tomat et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The redoxome

(2010) Maike Thamsen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The lysosome among targets of metformin: new anti-inflammatory uses for an old drug?

(2010) Thomas D Lockwood   EXPERT OPINION ON THERAPEUTIC TARGETS

Mucolipins: Intracellular TRPML1-3 channels

(2010) Xiping Cheng et al.   FEBS LETTERS

Cysteine/cystine redox signaling in cardiovascular disease

(2010) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters

(2010) Smitha Sreedharan et al.   GENE

Distinct Early Inflammatory Events during Ear Tissue Regeneration in Mice Selected for High Inflammation Bearing Slc11a1 R and S Alleles

(2010) Tatiane Canhamero et al.   INFLAMMATION

Zn(II) Complexes of Glutathione Disulfide: Structural Basis of Elevated Stabilities

(2010) Artur Krȩżel et al.   INORGANIC CHEMISTRY

State-dependent Inhibition of TRPM2 Channel by Acidic pH

(2010) Wei Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel

(2010) Jonathan L. Eichelsdoerfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cation counterflux supports lysosomal acidification

(2010) Benjamin E. Steinberg et al.   JOURNAL OF CELL BIOLOGY

Heteromultimeric TRPML channel assemblies play a crucial role in the regulation of cell viability models and starvation-induced autophagy

(2010) D. A. Zeevi et al.   JOURNAL OF CELL SCIENCE

Specialized roles for cysteine cathepsins in health and disease

(2010) Jochen Reiser et al.   JOURNAL OF CLINICAL INVESTIGATION

Cysteine proteases as targets for metal-based drugs

(2010) Simon P. Fricker   Metallomics

Zinc proteomes, phylogenetics and evolution

(2010) Leonardo Decaria et al.   Metallomics

The isolated Cys2His2 site in EC metallothionein mediates metal-specific protein folding

(2010) Oksana Iryna Leszczyszyn et al.   Molecular BioSystems

Macroautophagy is defective in mucolipin-1-deficient mouse neurons

(2010) Cyntia Curcio-Morelli et al.   NEUROBIOLOGY OF DISEASE

TRP channels and their implications in metabolic diseases

(2010) Zhiming Zhu et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses

(2010) S. C. Maughan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NADPH oxidase activity controls phagosomal proteolysis in macrophages through modulation of the lumenal redox environment of phagosomes

(2010) J. M. Rybicka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective Cross-Presentation of Viral Antigens in GILT-Free Mice

(2010) R. Singh et al.   SCIENCE

Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse

(2009) Lianne C. Hsing et al.   JOURNAL OF AUTOIMMUNITY

Zn2+Activates Large Conductance Ca2+-activated K+Channel via an Intracellular Domain

(2009) Shangwei Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells

(2009) Tolunay B. Aydemir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus

(2009) Min Chen et al.   JOURNAL OF NEUROCHEMISTRY

Zinc activates damage-sensing TRPA1 ion channels

(2009) Hongzhen Hu et al.   Nature Chemical Biology

Linking Chronic Infection and Autoimmune Diseases: Mycobacterium avium Subspecies paratuberculosis, SLC11A1 Polymorphisms and Type-1 Diabetes Mellitus

(2009) Daniela Paccagnini et al.   PLoS One

A protein microarray-based analysis ofS-nitrosylation

(2009) Matthew W. Foster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantifying the global cellular thiol-disulfide status

(2009) R. E. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry

(2008) Elizabeth M. Nolan et al.   ACCOUNTS OF CHEMICAL RESEARCH

High affinity Zn2+ inhibitory site(s) for the trypsin-like peptidase of the 20S proteasome

(2008) Aktar Uzzaman Chouduri et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mucolipin 1 channel activity is regulated by protein kinase A-mediated phosphorylation

(2008) Silvia Vergarajauregui et al.   BIOCHEMICAL JOURNAL

Mechanisms of mammalian zinc-regulated gene expression: Figure 1

(2008) Kelly A. Jackson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of cathepsin K activity by hydrogen peroxide

(2008) Emmanuel Godat et al.   BIOLOGICAL CHEMISTRY

Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma

(2008) Oliver G. Goldstein et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens

(2008) Y. D. Dai et al.   DIABETES

Autocatalytic processing of procathepsin B is triggered by proenzyme activity

(2008) Jerica Rozman Pungerčar et al.   FEBS Journal

NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis

(2008) Ö. Ates et al.   International Journal of Immunogenetics

Association of SLC11A1 promoter polymorphisms with the incidence of autoimmune and inflammatory diseases: A meta-analysis

(2008) Bronwyn A. O'Brien et al.   JOURNAL OF AUTOIMMUNITY

Glutathione depletion reveals impairment of antigen processing and inhibition of cathepsin activity by nitric oxide in antigen-presenting cells

(2008) Geneviève Lemaire et al.   MOLECULAR IMMUNOLOGY

Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

(2008) K. Girijashanker et al.   MOLECULAR PHARMACOLOGY

Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein

(2008) Daouda A K Traoré et al.   Nature Chemical Biology

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY

The Transporter Classification Database: recent advances

(2008) M. H. Saier et al.   NUCLEIC ACIDS RESEARCH

Analysis of metal-binding proteins separated by non-denaturating gel electrophoresis using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

(2008) J. Susanne Becker et al.   TALANTA