Recent Progress on C-4-Modified Podophyllotoxin Analogs as Potent Antitumor Agents

Semi-Synthesis and Biological Evaluation of 1,2,3-Triazole-Based Podophyllotoxin Congeners as Potent Antitumor Agents Inducing Apoptosis in HepG2 Cells

(2012) Jinying Chen et al.   ARCHIV DER PHARMAZIE

Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4′-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents

(2012) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents

(2012) Yingqian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 4β-(1,3,4-oxadiazole-2-amino)-podophyllotoxin derivatives

(2012) Jie Ren et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives

(2012) Yingqian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and anticancer activity of heteroaromatic linked 4β-amido podophyllotoxins as apoptotic inducing agents

(2012) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy

(2012) Carmen Sanmartín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis and Antimitotic and Tubulin Interaction Profiles of Novel Pinacol Derivatives of Podophyllotoxins

(2012) Andrés Abad et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of 4α/4β-Imidazolyl Podophyllotoxin Analogues as Antitumor Agents

(2011) Hai Shang et al.   ARCHIV DER PHARMAZIE

Synthesis and Cytotoxicity Evaluation of Novel Podophyllotoxin Derivatives

(2011) Wang Chengniu et al.   ARCHIV DER PHARMAZIE

Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents

(2011) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents

(2011) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives

(2011) Ying-Qian Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of aroylthiourea derivatives of 4-β-amino-4'-O-demethyl-4-desoxypodophyllotoxin as novel topoisomerase II inhibitors

(2011) Yu Zhao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

4β-[(4-Alkyl)-1,2,3-triazol-1-yl] podophyllotoxins as anticancer compounds: Design, synthesis and biological evaluation

(2011) Doma Mahendhar Reddy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 4β-triazole-podophyllotoxin derivatives by azide–alkyne cycloaddition and biological evaluation as potential antitumor agents

(2011) Hong Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and anticancer activity of 4β-alkylamidochalcone and 4β-cinnamido linked podophyllotoxins as apoptotic inducing agents

(2011) Ahmed Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor activity of novel podophyllotoxin derivatives against multidrug-resistant cancer cells

(2011) Yong-En Guo et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Recent Advances in Semisynthesis, Biosynthesis, Biological Activities,Mode of Action, and Structure-Activity Relationship of Podophyllotoxins:An Update (2008-2010)

(2011) M. Lv et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Design, semisynthesis and insecticidal activity of novel podophyllotoxin derivatives against Brontispa longissima in vivo

(2011) Ying-Qian Liu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Tubulin-guided dynamic combinatorial library of thiocolchicine–podophyllotoxin conjugates

(2011) Graziella Cappelletti et al.   TETRAHEDRON

Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities

(2010) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

An efficient one-pot synthesis of benzothiazolo-4β-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity

(2010) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of new 4β-anilino-4′-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

(2010) Li Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of insecticidal activity of podophyllotoxin derivatives against Brontispa longissima

(2010) Ying-Qian Liu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

L1EPO, a Novel Podophyllotoxin Derivative Overcomes P-Glycoprotein-Mediated Multidrug Resistance in K562/A02 Cell Line

(2009) Hong Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Synthesis and biological evaluation of novel conjugates of podophyllotoxin and 5-FU as antineoplastic agents

(2009) Shi-Wu Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antitumor activity of deoxypodophyllotoxin isolated from Anthriscus sylvestris: Induction of G2/M cell cycle arrest and caspase-dependent apoptosis

(2009) Yeonjoong Yong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel semisynthetic spin-labeled derivatives of podophyllotoxin with cytotoxic and antioxidative activity

(2009) Jia-Qiang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells

(2009) Soon Young Shin et al.   CANCER LETTERS

Synthesis and biological evaluation of novel thiocolchicine–podophyllotoxin conjugates

(2009) Daniele Passarella et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs

(2009) Ya Qiong Chen et al.   MOLECULES AND CELLS

Design, Synthesis, and Biological Testing of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxin Analogues as Antitumor Agents

(2008) Pitta B. Reddy et al.   ARCHIV DER PHARMAZIE

Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III

(2008) Daniele Passarella et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis and Cytotoxicity of Novel Podophyllotoxin Derivatives

(2008) Peng-Fei Yu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis and Biological Evaluation of 4β-[(4-Substituted)-1,2,3-triazol-1-yl]podophyllotoxins as Potential Anticancer Agents

(2008) Pitta Bhaskar Reddy et al.   CHEMISTRY & BIODIVERSITY

A Review on Hemisynthesis, Biosynthesis, Biological Activities, Mode of Action, and Structure-Activity Relationship of Podophyllotoxins: 2003- 2007

(2008) Hui Xu et al.   CURRENT MEDICINAL CHEMISTRY

First synthesis of novel spin-labeled derivatives of camptothecin as potential antineoplastic agents

(2008) Ying-Qian Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel derivatives of bispodophyllotoxin as potential antineoplastic agents–Part XVI1

(2008) Ying-Qian Liu et al.   NATURAL PRODUCT RESEARCH

Synthesis and insecticidal activities of novel derivatives of podophyllotoxin: Part XII

(2008) Ying-Qian Liu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Deoxypodophyllotoxin, flavolignan, from Anthriscus sylvestris Hoffm. inhibits migration and MMP-9 via MAPK pathways in TNF-α-induced HASMC

(2008) Seok-Jong Suh et al.   VASCULAR PHARMACOLOGY

Seleno-podophyllotoxin derivatives induce hepatoma SMMC-7721 cell apoptosis through Bax pathway

(2007) R MIAO et al.   CELL BIOLOGY INTERNATIONAL

Studies on novel 4β-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents

(2007) Bilal A. Bhat et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY