Journal
CHEMISTRY & BIODIVERSITY
Volume 5, Issue 9, Pages 1792-1802Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200890168
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A series of novel 4 beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin derivatives were synthesized by employing Cu-1-catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT-29, HCT-15, 502713, HOP-62, A-549, MCF-7, and SF-295). The compounds 9b, 9c, 9c, 9f, and 9h showed significant cytotoxic activities especially against HT-29, HCT-15, 502713, cell lines.
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