Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 19, Issue 9, Pages 2975-2979Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2011.03.030
Keywords
Podophyllotoxin; Epipodophyllotoxin; Carbamate; Topoisomerase II; Cytotoxicity
Funding
- UGC, New Delhi
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A series of new 4 beta-carbamoyl epipodophyllotoxin analogues have been synthesized and evaluated for their anticancer activity against eleven cancer cell lines including Zr-75-1, MCF7, KB, Gurav, DWD, Colo 205, A-549, Hop62, PC3, SiHa and A-2780. Most of the compounds exhibited better growth-inhibition activities against tested cell lines than that of etoposide. Further, compounds 6g and 6i are also evaluated for their DNA topoisomerase-II (topo-II) inhibition activity and they exhibited significant inhibition of topo-II catalytic activity comparable to etoposide. (C) 2011 Elsevier Ltd. All rights reserved.
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