A Cutting-Edge View on the Current State of Antiviral Drug Development
Published 2013 View Full Article
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Title
A Cutting-Edge View on the Current State of Antiviral Drug Development
Authors
Keywords
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Journal
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages n/a-n/a
Publisher
Wiley
Online
2013-03-14
DOI
10.1002/med.21281
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Note: Only part of the references are listed.- Intrapulmonary Distribution and Pharmacokinetics of Laninamivir, a Neuraminidase Inhibitor, after a Single Inhaled Administration of Its Prodrug, Laninamivir Octanoate, in Healthy Volunteers
- (2012) Hitoshi Ishizuka et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation
- (2012) Yacine Abed et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers
- (2012) Jarasvech Chinsangaram et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cobicistat Boosts the Intestinal Absorption of Transport Substrates, Including HIV Protease Inhibitors and GS-7340,In Vitro
- (2012) Eve-Irene Lepist et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice
- (2012) E. Bart Tarbet et al. ANTIVIRAL RESEARCH
- Orthopoxvirus targets for the development of new antiviral agents
- (2012) Mark N. Prichard et al. ANTIVIRAL RESEARCH
- Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era
- (2012) Erik De Clercq BIOCHEMICAL PHARMACOLOGY
- Peramivir Use for Treatment of Hospitalized Patients With Influenza A(H1N1)pdm09 Under Emergency Use Authorization, October 2009-June 2010
- (2012) Y. Yu et al. CLINICAL INFECTIOUS DISEASES
- Emergency Use Authorization for Intravenous Peramivir: Evaluation of Safety in the Treatment of Hospitalized Patients Infected With 2009 H1N1 Influenza A Virus
- (2012) A. Sorbello et al. CLINICAL INFECTIOUS DISEASES
- Safety of the long-acting neuraminidase inhibitor laninamivir octanoate hydrate in post-marketing surveillance
- (2012) Seizaburo Kashiwagi et al. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Antiviral therapies: Focus on hepatitis B reverse transcriptase
- (2012) Eleftherios Michailidis et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir
- (2012) J. L. McKimm-Breschkin et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Management of treatment failure in chronic hepatitis B
- (2012) Fabien Zoulim et al. JOURNAL OF HEPATOLOGY
- Detection of Molluscum Contagiosum Virus (MCV) DNA in the Plasma of an Immunocompromised Patient and Possible Reduction of MCV DNA With CMX-001
- (2012) Jeffrey I. Cohen et al. JOURNAL OF INFECTIOUS DISEASES
- ASP2151 for the Treatment of Genital Herpes: A Randomized, Double-Blind, Placebo- and Valacyclovir-Controlled, Dose-Finding Study
- (2012) Stephen Tyring et al. JOURNAL OF INFECTIOUS DISEASES
- Progressive Vaccinia: Case Description and Laboratory-Guided Therapy With Vaccinia Immune Globulin, ST-246, and CMX001
- (2012) E. R. Lederman et al. JOURNAL OF INFECTIOUS DISEASES
- Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial
- (2012) Edwin DeJesus et al. LANCET
- Tenofovir: Quo Vadis Anno 2012 (Where Is It Going in the Year 2012)?
- (2012) Erik De Clercq MEDICINAL RESEARCH REVIEWS
- Structure-Activity Relationships in the Development of Allosteric Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors: Ten Years of Research
- (2012) Romain Haudecoeur et al. MEDICINAL RESEARCH REVIEWS
- Mechanism for Effective Lymphoid Cell and Tissue Loading Following Oral Administration of Nucleotide Prodrug GS-7340
- (2012) Darius Babusis et al. MOLECULAR PHARMACEUTICS
- Ten Paths to the Discovery of Antivirally Active Nucleoside and Nucleotide Analogues
- (2012) Erik De Clercq NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09
- (2012) Janice K. Louie et al. PLoS One
- The race for interferon-free HCV therapies: a snapshot by the spring of 2012
- (2012) Erik De Clercq REVIEWS IN MEDICAL VIROLOGY
- Benefits and Risks of Influenza Research: Lessons Learned
- (2012) A. S. Fauci et al. SCIENCE
- Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets
- (2012) S. Herfst et al. SCIENCE
- Direct-acting and host-targeting HCV inhibitors: current and future directions
- (2012) Laurent Chatel-Chaix et al. Current Opinion in Virology
- First Report of Successful Treatment of Multidrug-Resistant Cytomegalovirus Disease with the Novel Anti-CMV Compound AIC246
- (2011) D. R. Kaul et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Efficacy, Safety, and Pharmacokinetics of Intravenous Peramivir in Children with 2009 Pandemic H1N1 Influenza A Virus Infection
- (2011) Norio Sugaya et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Efficacy of Single Intravenous Injection of Peramivir against Influenza B Virus Infection in Ferrets and Cynomolgus Macaques
- (2011) Mitsutaka Kitano et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Pharmacokinetics and Safety of FV-100, a Novel Oral Anti-Herpes Zoster Nucleoside Analogue, Administered in Single and Multiple Doses to Healthy Young Adult and Elderly Adult Volunteers
- (2011) Helen S. Pentikis et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Phase III Randomized, Double-Blind Study Comparing Single-Dose Intravenous Peramivir with Oral Oseltamivir in Patients with Seasonal Influenza Virus Infection
- (2011) Shigeru Kohno et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2011) Mark N. Prichard et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- Clinical Experience in Adults and Children Treated with Intravenous Peramivir for 2009 Influenza A (H1N1) Under an Emergency IND Program in the United States
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- (2010) S. Kubo et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2010) S. Kohno et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2010) P. Lischka et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2010) N. Sugaya et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2010) Hitoshi Ishizuka et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2010) M. C. Wolf et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) M. R. St.Vincent et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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