Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease
出版年份 2011 全文链接
标题
Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease
作者
关键词
-
出版物
MEDICINAL RESEARCH REVIEWS
Volume 33, Issue 1, Pages 139-189
出版商
Wiley
发表日期
2011-07-27
DOI
10.1002/med.20248
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Selective Acetylcholinesterase Inhibitor Activated by Acetylcholinesterase Releases an Active Chelator with Neurorescuing and Anti-Amyloid Activities
- (2010) Hailin Zheng et al. ACS Chemical Neuroscience
- Strategies for the Inhibition of Protein Aggregation in Human Diseases
- (2010) Manuela Bartolini et al. CHEMBIOCHEM
- Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter
- (2010) Narihiro Toda et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates
- (2010) Pelayo Camps et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Immune-Inflammatory Responses and Oxidative Stress in Alzheimers Disease: Therapeutic Implications
- (2010) D. Bona et al. CURRENT PHARMACEUTICAL DESIGN
- Calcium Signaling and Amyloid Toxicity in Alzheimer Disease
- (2010) Angelo Demuro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1Receptors
- (2010) Lei Fang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB1Receptor Antagonism
- (2010) Jos H. M. Lange et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Biological Evaluation of a Novel Class of γ-Secretase Modulators with PPARγ Activity
- (2010) Martina Hieke et al. JOURNAL OF MEDICINAL CHEMISTRY
- Bivalent β-Carbolines as Potential Multitarget Anti-Alzheimer Agents
- (2010) Yvonne Rook et al. JOURNAL OF MEDICINAL CHEMISTRY
- Calcium Signalling and Alzheimer’s Disease
- (2010) Michael J. Berridge NEUROCHEMICAL RESEARCH
- Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
- (2010) Bart De Strooper PHYSIOLOGICAL REVIEWS
- ER Calcium and Alzheimer's Disease: In a State of Flux
- (2010) M. P. Mattson Science Signaling
- Drug development for Alzheimer's disease: Where are we now and where are we headed?
- (2009) Marwan N. Sabbagh American Journal Geriatric Pharmacotherapy
- Alzheimer's Disease: From Pathology to Therapeutic Approaches
- (2009) Roland Jakob-Roetne et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase
- (2009) Yiping Zhu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Medicinal Inorganic Chemistry Approaches to Passivation and Removal of Aberrant Metal Ions in Disease
- (2009) Lauren E. Scott et al. CHEMICAL REVIEWS
- Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity
- (2009) Sung-Wuk Jang et al. CHEMISTRY & BIOLOGY
- Searching for Disease Modifiers-PKC Activation and HDAC Inhibition-A Dual Drug Approach to Alzheimer's Disease that Decreases Aβ Production while Blocking Oxidative Stress
- (2009) Alan P. Kozikowski et al. ChemMedChem
- Tacrine-Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties
- (2009) María Isabel Fernández-Bachiller et al. ChemMedChem
- Cholinesterase inhibition: is there evidence for disease-modifying effects?
- (2009) Michael Shanks et al. CURRENT MEDICAL RESEARCH AND OPINION
- Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy
- (2009) Tim Storr et al. DALTON TRANSACTIONS
- GSK3: A possible link between beta amyloid peptide and tau protein
- (2009) Félix Hernández et al. EXPERIMENTAL NEUROLOGY
- Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease
- (2009) Gjumrakch Aliev et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Novel piperazine derivative PMS1339 exhibits tri-functional properties and cognitive improvement in mice
- (2009) Jean Marc Miezan Ezoulin et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- The Crystal Structure of a Complex of Acetylcholinesterase with a Bis-(−)-nor-meptazinol Derivative Reveals Disruption of the Catalytic Triad
- (2009) Aviv Paz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Biological Evaluation of New 5-HT4Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease
- (2009) Olivier Russo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Site-Activated Multifunctional Chelator with Acetylcholinesterase and Neuroprotective−Neurorestorative Moieties for Alzheimer’s Therapy
- (2009) Hailin Zheng et al. JOURNAL OF MEDICINAL CHEMISTRY
- Neuroprotective and Cholinergic Properties of Multifunctional Glutamic Acid Derivatives for the Treatment of Alzheimer’s Disease
- (2009) Mariana P. Arce et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tacripyrines, the First Tacrine−Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease
- (2009) José Marco-Contelles et al. JOURNAL OF MEDICINAL CHEMISTRY
- Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks
- (2009) Maria Laura Bolognesi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Naturally occurring phytochemicals for the prevention of Alzheimer’s disease
- (2009) Jiyoung Kim et al. JOURNAL OF NEUROCHEMISTRY
- Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Adult Brain
- (2009) Akihiko Takashima JOURNAL OF PHARMACOLOGICAL SCIENCES
- Design, Selection, and Characterization of Thioflavin-Based Intercalation Compounds with Metal Chelating Properties for Application in Alzheimer’s Disease
- (2009) Cristina Rodríguez-Rodríguez et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Small Molecule Modulators of Copper-Induced Aβ Aggregation
- (2009) Sarmad S. Hindo et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies
- (2009) Kurt R. Brunden et al. NATURE REVIEWS DRUG DISCOVERY
- Natural Antioxidants Protect Neurons in Alzheimer’s Disease and Parkinson’s Disease
- (2009) Baolu Zhao NEUROCHEMICAL RESEARCH
- Soluble Oligomers of Amyloid β Protein Facilitate Hippocampal Long-Term Depression by Disrupting Neuronal Glutamate Uptake
- (2009) Shaomin Li et al. NEURON
- The Role of Apolipoprotein E in Alzheimer's Disease
- (2009) Jungsu Kim et al. NEURON
- A New Tacrine–Melatonin Hybrid Reduces Amyloid Burden and Behavioral Deficits in a Mouse Model of Alzheimer’s Disease
- (2009) Carlos Spuch et al. NEUROTOXICITY RESEARCH
- Multiple roles of HDAC inhibition in neurodegenerative conditions
- (2009) De-Maw Chuang et al. TRENDS IN NEUROSCIENCES
- Cognitive Function Over Time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT)
- (2008) ARCHIVES OF NEUROLOGY
- Current approaches in the treatment of Alzheimer's disease
- (2008) Reena S. Shah et al. BIOMEDICINE & PHARMACOTHERAPY
- New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties
- (2008) Rafael León et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors
- (2008) J.N. Cumming et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates
- (2008) Lei Fang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Beta-Secretase: Structure, Function, and Evolution
- (2008) Chitra Venugopal et al. CNS & Neurological Disorders-Drug Targets
- Mechanism of Tau-Induced Neurodegeneration in Alzheimer Disease and Related Tauopathies
- (2008) Alejandra del Alonso et al. Current Alzheimer Research
- Metals in Alzheimer's and Parkinson's Diseases
- (2008) Kevin J Barnham et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Treatment Options in Alzheimer’s Disease: Maximizing Benefit, Managing Expectations
- (2008) Martin R. Farlow et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity
- (2008) Kenjiro Ono et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pharmacotherapeutic targets in Alzheimer's disease
- (2008) Yif'at Biran et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1
- (2008) Nassima Oumata et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure−Activity Relationships of Acetylcholinesterase Noncovalent Inhibitors Based on a Polyamine Backbone. 4. Further Investigation on the Inner Spacer
- (2008) Vincenzo Tumiatti et al. JOURNAL OF MEDICINAL CHEMISTRY
- Benzofuran-Based Hybrid Compounds for the Inhibition of Cholinesterase Activity, β Amyloid Aggregation, and Aβ Neurotoxicity
- (2008) Stefano Rizzo et al. JOURNAL OF MEDICINAL CHEMISTRY
- Novel Donepezil-Based Inhibitors of Acetyl- and Butyrylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation
- (2008) Pelayo Camps et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of Acetylcholinesterase, β-Amyloid Aggregation, and NMDA Receptors in Alzheimer’s Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush
- (2008) Michela Rosini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Bis-(−)-nor-meptazinols as Novel Nanomolar Cholinesterase Inhibitors with High Inhibitory Potency on Amyloid-β Aggregation
- (2008) Qiong Xie et al. JOURNAL OF MEDICINAL CHEMISTRY
- Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
- (2008) Andrea Cavalli et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Novel Cholinesterase–Monoamine Oxidase Inhibitor and Antioxidant, Ladostigil, Confers Neuroprotection in Neuroblastoma Cells and Aged Rats
- (2008) Orit Bar-Am et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Preclinical efficacy on GSK-3 inhibitors: Towards a future generation of powerful drugs
- (2008) Ana Martinez MEDICINAL RESEARCH REVIEWS
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- M1 Muscarinic Agonists Target Major Hallmarks of Alzheimer’s Disease – The Pivotal Role of Brain M1 Receptors
- (2008) Abraham Fisher Neurodegenerative Diseases
- Linking Calcium to Aβ and Alzheimer's Disease
- (2008) Kim N. Green et al. NEURON
- PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease
- (2008) Gary Landreth et al. Neurotherapeutics
- Memoquin: A multi-target-directed ligand as an innovative therapeutic opportunity for Alzheimer’s disease
- (2008) Maria Laura Bolognesi et al. Neurotherapeutics
- Promising anti-Alzheimer’s dimer bis(7)-tacrine reduces β-amyloid generation by directly inhibiting BACE-1 activity
- (2007) Hongjun Fu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Lead identification of acetylcholinesterase inhibitors–histamine H3 receptor antagonists from molecular modeling
- (2007) Scott D. Bembenek et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation
- (2007) Arun K. Ghosh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds
- (2007) Lorna Piazzi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death
- (2007) Rafael León et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Targeting multiple Alzheimer’s disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
- (2007) Tamar Amit et al. FASEB JOURNAL
- Characterization of Copper Interactions with Alzheimer Amyloid β Peptides
- (2003) Craig S. Atwood et al. JOURNAL OF NEUROCHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started