Review
Environmental Sciences
Chunqiong Liu, Kai Shi
Summary: Studying the sensitivity of O3 formation to its precursors has advanced in the past decades with the use of nonlinear methods that reveal emergent properties. Incorporating these emergent properties into modern models is essential for accurately assessing O3 formation under combined air pollution environments. The scaling property of coupling correlation detected in real observations could help test and improve the simulation performance of modern models.
ENVIRONMENTAL POLLUTION
(2021)
Article
Food Science & Technology
Sharad Kharel, Archana Gautam, Manish Mahotra, Nasya Martin Theniko, Say Chye Joachim Loo
Summary: This study valorizes soybean by-product okara into nutritional extracts for encapsulating micronutrients, utilizing spray-drying technique to produce optimized dual-micronutrient formulations with sequential release profiles to potentially enhance their bioavailability.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Cell Biology
Miri Adler, Arun R. Chavan, Ruslan Medzhitov
Summary: Animal tissues are composed of multiple cell types with different relationships, which play a critical role in understanding tissue biology. By introducing the concept of cell categories, we can explore the modular principles and different tissue modules, such as composition, structure, and function. Cell diversity and relations provide a new perspective on the underlying principles of tissue organization in health and disease.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Chemistry, Medicinal
Shamama Javed, Bharti Mangla, Waquar Ahsan
Summary: Propolis, a natural resinous mixture produced by honey bees, has diverse biological activities and versatile applications in the pharmaceutical industry. Due to its hydrophobic nature, nanotechnological approaches are used to improve its bioavailability. Nanopropolis, prepared using various nanoparticles and formulations, shows improved solubility, bioavailability, and penetration profiles, and has potential applications in the development of products such as sunscreens and mouthwashes.
PHYTOTHERAPY RESEARCH
(2022)
Review
Plant Sciences
Sangam L. L. Dwivedi, Ana Luisa Garcia-Oliveira, Mahalingam Govindaraj, Rodomiro Ortiz
Summary: Malnutrition leads to significant socio-economic costs. Climate change negatively affects agricultural productivity and nutritional quality. Improving crop production and biofortification through genetic engineering are crucial for addressing malnutrition. This review provides updates on nutrient acquisition, transport, and storage in plants, and includes information on breeding nutrient-dense crops and the molecular basis of nutrient absorption in humans.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Environmental Sciences
Farid Juillot, Leonore Flipo, Mickael Tharaud, Eric Viollier, Vincent Noe, Pierre Le Pape, Jean-Michel Fernandez, Benjamin Moreton, Guillaume Morin
Summary: This study investigates the bioavailability of trace metals in coastal sediments downstream of an ultramafic catchment in New Caledonia. The results show a decreasing shore-to-reef gradient in the bioavailability of nickel and chromium, indicating the importance of ultramafic sediments in coastal deposition.
Article
Biochemistry & Molecular Biology
Hao Wang, Wei Yu, Yibo Wang, Ruihao Wu, Yifei Dai, Ye Deng, Shijun Wang, Jinxiang Yuan, Rubin Tan
Summary: Cardiovascular diseases are a major cause of global mortality, and abnormalities in p53 and mitochondrial function contribute to their occurrence and development. Targeting p53 or mitochondria holds promise as a therapeutic approach for combating cardiovascular diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Medicinal
Anton J. M. Loonen, Taichi Ochi, Lisanne M. Geers, German G. Simutkin, Nikolay A. Bokhan, Daniel J. Touw, Bob Wilffert, Alexander N. Kornetov, Svetlana A. Ivanova
Summary: The article suggests that clinical depression can be viewed as a typical human response to loss or adversity, with recovery relying mainly on natural resilience mechanisms. Treatment aims to undermine the biopsychosocial factors that prevent the natural recovery process from functioning effectively.
Review
Endocrinology & Metabolism
W. Timothy Garvey
Summary: By treating obesity as a chronic disease and focusing on preventing and treating complications, the effectiveness of weight loss therapy can be enhanced for better health outcomes and reduced mortality. The advent of second-generation medications allows obesity to be managed similar to other chronic diseases, enabling a treat-to-target approach for effective treatment and prevention of specific complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Editorial Material
Clinical Neurology
Mark J. Edwards
Summary: Patients with medically unexplained or functional symptoms, often avoided by health professionals, may hold the key to a more successful, meaningful, and just system of medical practice. They prompt us to consider the human and participatory aspect of illness, which is often neglected in medical training and practice. There is room for improvement in addressing this aspect in healthcare.
Review
Cell Biology
Jancy Johnson, Mozhgan Shojaee, James Mitchell Crow, Ramin Khanabdali
Summary: MSCs, as a leading cell source for stem cell therapy, have regenerative and immunomodulatory properties, but face challenges in clinical applications. EVs and EEVs, as potential cell-free alternatives, may overcome these challenges in the clinical application of MSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Mariachiara Bianco, Giovanni Ventura, Cosima Damiana Calvano, Ilario Losito, Tommaso R. Cataldi
Summary: With the introduction of novel nutrient sources with high protein content in the consumer market, safety evaluation studies on potentially allergenic proteins are necessary. This study presents a method for establishing sequence-based homology between proteins of spirulina and chlorella micro-algae and known allergens through database searches. Several potentially allergenic proteins were identified, and further immunochemical tests are required to confirm their allergenicity.
Article
Biochemistry & Molecular Biology
Anne Van der Meeren, Catherine Berthomieu, Agnes Moureau, Martine Defrance, Nina M. Griffiths
Summary: The speciation of actinides and their ability to bind to bioligands have an impact on their behavior in living organisms. Understanding these interactions is vital for estimating radiological dose and improving treatment strategies for accidental contamination. This study used a bi-compartmental and dynamic assay to investigate the interactions between the actinides plutonium (Pu) and americium (Am) and endogenous or exogenous ligands. The results showed differences in the formation of actinide-protein or actinide-DTPA complexes in physiologically relevant media. This assay could be used to determine the ability of different actinides to interact with specific proteins or drug candidates in complex physiological environments.
Article
Multidisciplinary Sciences
Juliana Kiio, Sophie Ochola, Ruth Nduati, Elizabeth Kuria, Scholastica Mathenge, Judith Okoth
Summary: Zinc deficiency is common among children with Moderate Acute Malnutrition (MAM) and can lead to growth failure and increased morbidity and mortality. Micronutrient powders (MNPs) are more effective than Corn-soy Blend (CSB) in improving zinc status.
Article
Oncology
Ashutosh Singh, Namyashree Nayak, Preeti Rathi, Deepanshu Verma, Rohit Sharma, Ashun Chaudhary, Alka Agarwal, Yamini Bhushan Tripathi, Neha Garg
Summary: The human microbiome, particularly the gut microbiome, has been shown to play a crucial role in influencing the efficacy and toxicity of chemotherapy and immunotherapy. Recent studies have highlighted how the microbiome can have an impact on the pharmacological effect of these cancer treatments, through mechanisms such as metabolism, enzymatic degradation, ecological differences, and immunomodulation. Researchers are actively exploring ways to leverage the microbiome to improve the effectiveness of cancer therapies and reduce their side effects.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
