Article
Biochemistry & Molecular Biology
Zhi-Yuan Lu, Lin Feng, Wei-Dan Jiang, Pei Wu, Yang Liu, Xiao-Wan Jin, Hong-Mei Ren, Sheng-Yao Kuang, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Xiao-Qiu Zhou
Summary: This study focused on the protective effects of dietary mannoligosaccharides (MOS) supplementation on the intestinal structural integrity of grass carp. The results showed that dietary MOS supplementation protected the microvillus of the intestine, reduced mucosal permeability, and maintained intestinal structural integrity through the inhibition of MLCK and RhoA/ROCK signaling pathways. These findings highlight the positive impact of dietary MOS supplementation on intestinal health.
Article
Multidisciplinary Sciences
Atul K. Srivastava, Bharat Somireddy Venkata, Yan Y. Sweat, Heather R. Rizzo, Lea Jean-Francois, Li Zuo, Kathleen W. Kurgan, Patrick Moore, Nitesh Shashikanth, Izabela Smok, Joseph R. Sachleben, Jerrold R. Turner, Stephen C. Meredith
Summary: This study investigates the effects of S408 phosphorylation on occludin protein structure and demonstrates its role in regulating intercellular junction function through interactions with other components.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Guo-Ping Zhao, Xiao-Yu Wang, Jin-Wang Li, Ran Wang, Fa-Zheng Ren, Guo-Fang Pang, Yi-Xuan Li
Summary: The study revealed that the neonicotinoid pesticide imidacloprid disrupts the permeability of the intestinal epithelial barrier, leading to an inflammatory response and down-regulation of tight junction proteins, especially involving the pregnane X receptor. This highlights the importance of considering the intestinal barrier disruption caused by IMI in assessing the safety of this class of pesticides.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Shen Zhuang, Ke Ming, Ning Ma, Jinrui Sun, Dehai Wang, Mingxing Ding, Yi Ding
Summary: A specific polysaccharide fraction (POPZ) from Portulaca oleracea L. was found to inhibit LPS-induced barrier injury and inflammatory responses in porcine intestinal epithelial monolayer, possibly through inactivating TLR4/NF-κB pathway and activating EGF/EGFR pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Chenlong Li, Hongshan Zheng, Jinsheng Xiong, Yuxin Huang, Haoyang Li, Hua Jin, Siqi Ai, Yingjie Wang, Tianqi Su, Guiyin Sun, Xu Xiao, Tianjiao Fu, Yujie Wang, Xin Gao, Peng Liang
Summary: This study investigates the role of miR-596-3p in brain metastasis of NSCLC. The results reveal that miR-596-3p inhibits the invasion of cancer cells and permeability of the blood brain barrier by modulating the YAP1-IL8 network. The findings suggest that miR-596-3p may serve as a potential therapeutic target for brain metastasis in NSCLC.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Chao Li, Liang Shi, Yuanbo Wang, Cheng Peng, Lei Wu, Yanshu Zhang, Zhongjun Du
Summary: Environmental exposure to lead can damage the central nervous system in humans, and high-fat diet has been suggested to impair neurocognitive function. This study investigated how high-fat diet exacerbates lead-induced disruption of blood-brain barrier integrity by disrupting tight junctions. The results showed that palmitic acid, a common saturated fatty acid, can increase BBB permeability and decrease the expression of tight junction proteins.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Plant Sciences
Mi Ri Kim, Su-Yeon Cho, Hee Ju Lee, Joo Yeon Kim, Uyen Tran Tu Nguyen, Ngoc Minh Ha, Ki Young Choi, Kwang Hyun Cha, Jeong-Ho Kim, Won Kyu Kim, Kyungsu Kang
Summary: Schisandrin C improves intestinal barrier formation and permeability dysfunction by regulating TJ protein expression and signaling pathways. This study is important for understanding the mechanisms of intestinal inflammation and permeability disorders and exploring new therapeutic approaches.
Article
Agriculture, Multidisciplinary
Xinyuan Zhao, Tao Zhang, Yudan Zheng, Zixuan Zhao, Wenjie Ding, Ziyang Zhang, Zeyao Zhang, Rui Wang, Man Jiao, Lei Liu, Shali Yu, Xiaoke Wang, Rongrong Huang, Qiyun Wu
Summary: Short-chain chlorinated paraffins (SCCPs) are toxic substances found in food that have been shown to have neurotoxic effects. This study investigated the mechanism by which SCCP exposure activates astrocytes and leads to neuroinflammation. The results showed that SCCP intake caused astrocyte activation and neuronal cell death, accompanied by changes in the gut microbiome and its metabolites. Depleting the gut microbiome through antibiotic treatment reduced astrocyte activation and inflammation induced by SCCPs. Furthermore, fecal microbiota transplantation from SCCP-treated mice to healthy mice resulted in increased astrocyte activation and inflammation. SCCP exposure also led to increased expression of zonulin and damage to tight junctions in the intestinal tract, which were inhibited by antibiotic treatment. These findings suggest that SCCP-induced astrocyte activation and neurotoxicity may be mediated by the gut microbiome-mediated zonulin expression and tight junction impairment.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Zoology
Zu-Bing Cao, Di Gao, Hui-Qun Yin, Hui Li, Teng-Teng Xu, Meng-Ya Zhang, Xin Wang, Qiu-Chen Liu, Ye-Lian Yan, Yang-Yang Ma, Tong Yu, Yun-Sheng Li, Yun-Hai Zhang
Summary: INO80 plays a crucial role in porcine pre-implantation embryonic development by promoting blastocyst formation and regulating lineage allocation. It functions by modulating the expression of key genes involved in tight junction assembly and fluid accumulation during blastocyst development.
ZOOLOGICAL RESEARCH
(2021)
Article
Food Science & Technology
Sefat E. Khuda, Ann V. Nguyen, Girdhari M. Sharma, Mohammad S. Alam, Kannan V. Balan, Kristina M. Williams
Summary: This study found that polysorbate-80 may enhance the absorption of allergens in a size-dependent manner by modulating paracellular permeability.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Sweta Ghosh, Caleb Samuel Whitley, Bodduluri Haribabu, Venkatakrishna Rao Jala
Summary: This review discusses the recent advances in understanding the role of gut microbial metabolites in regulating intestinal barrier function. While the mechanisms of action of these metabolites are still being explored, they likely impact gut barrier function through shared pathways. Utilizing beneficial microbiota and their metabolites to restore pathophysiological balance may prove to be a valuable therapeutic tool amidst advancing technology and expanding knowledge.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chuyu Xi, Xiaoxue Liu, Wenjie Li, Hairan Su, Hao Yang, Zhongbin Bai, Yang Tian, Shuang Song
Summary: Changes in intestinal mucosal barrier permeability play important roles in the development of food allergies. This study found that the protein from camellia and Moringa oleifera leaves could increase intestinal permeability and decrease the expression of tight junction proteins, thus promoting the development of food allergies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Yi Zhou, Ling Duan, Yan Zeng, Xu Song, Kangcheng Pan, Lili Niu, Yang Pu, Jiakun Li, Abdul Khalique, Jing Fang, Bo Jing, Dong Zeng, Bairong Shen, Xueqin Ni
Summary: The intestinal microbiota of captive pandas, characterized by a high abundance of Enterobacteriaceae, has led to intestinal infection. Probiotic supplement Lactiplantibacillus plantarum BSG201683 (L. plantarum G83) has shown effectiveness in improving intestinal barrier function and inflammation. In vitro studies demonstrated that L. plantarum G83 reduced paracellular permeability, decreased proinflammatory cytokines, and enhanced anti-inflammatory responses through Toll-like receptor 4/ nuclear factor kappa-B (TLR4/NF-?B) signaling pathways.
Article
Multidisciplinary Sciences
Heidrun L. Deissler, Catharina Busch, Armin Wolf, Matus Rehak
Summary: The study suggests that Beovu injection may affect the barrier formed by retinal endothelial cells, leading to conditions such as retinal vasculitis or retinal vein occlusion. Beovu significantly reduces the cell index and alters cell adhesion as well as the expression of claudin-1, an essential component of the barrier.
SCIENTIFIC REPORTS
(2022)
Article
Fisheries
Zhiruo Miao, Zhiying Miao, Min Liu, Shiwen Xu
Summary: This study investigated the intestinal injury caused by the pesticide IMI in common carps and whether the hormone melatonin (MT) can attenuate this injury. The results showed that IMI altered the composition and function of the intestinal microbiota, disrupted the integrity of the intestinal structure, and increased intestinal permeability. It was found that IMI increased intestinal tight junction permeability through the induction of peptidoglycan (PGN) secretion. However, the addition of MT significantly reduced IMI-induced intestinal toxicity by inhibiting PGN synthesis and restoring tight junction permeability, thereby reducing intestinal injury.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)