Retinoic Acid and Its Role in Modulating Intestinal Innate Immunity

Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age

(2016) Sudhanshu Agrawal et al.   Aging-US

Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System

(2016) Alexandre Larange et al.   Annual Review of Immunology

Peripheral Lymphoid Volume Expansion and Maintenance Are Controlled by Gut Microbiota via RALDH+ Dendritic Cells

(2016) Zongde Zhang et al.   IMMUNITY

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 + T Cell-Mediated Immunity in Colorectal Cancer

(2016) Nupur Bhattacharya et al.   IMMUNITY

Retinoic acid-primed human dendritic cells inhibit Th9 cells and induce Th1/Th17 cell differentiation

(2016) Ritika Rampal et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Biomarkers of Nutrition for Development (BOND)—Vitamin A Review

(2016) Sherry A Tanumihardjo et al.   JOURNAL OF NUTRITION

Molecular Basis for Vitamin A Uptake and Storage in Vertebrates

(2016) Sylwia Chelstowska et al.   Nutrients

Retinoic Acid as a Modulator of T Cell Immunity

(2016) Maria Bono et al.   Nutrients

Vitamin A Inhibits Development of Dextran Sulfate Sodium-Induced Colitis and Colon Cancer in a Mouse Model

(2016) Isao Okayasu et al.   Biomed Research International

The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells

(2015) Zhong-Min Liu et al.   Cellular & Molecular Immunology

Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells

(2015) B. Ruiter et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut

(2015) Myung H. Kim et al.   IMMUNITY

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

(2015) Jochem H. Bernink et al.   IMMUNITY

Differentiation and function of group 3 innate lymphoid cells, from embryo to adult

(2015) Serge A. van de Pavert et al.   INTERNATIONAL IMMUNOLOGY

Cutting Edge: Retinoic Acid Signaling in B Cells Is Essential for Oral Immunization and Microflora Composition

(2015) Eirini Pantazi et al.   JOURNAL OF IMMUNOLOGY

The Impact of ATRA on Shaping Human Myeloid Cell Responses to Epithelial Cell-Derived Stimuli and on T-Lymphocyte Polarization

(2015) Arunima Chatterjee et al.   MEDIATORS OF INFLAMMATION

Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid

(2015) R Zeng et al.   Mucosal Immunology

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

(2015) Gregory F Sonnenberg et al.   NATURE MEDICINE

Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation

(2015) Gabriela Tejón et al.   Biomed Research International

Depletion of Host CCR7+ Dendritic Cells Prevented Donor T Cell Tissue Tropism in Anti-CD3–Conditioned Recipients

(2014) Wei He et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

Oral Tolerance Can Be Established via Gap Junction Transfer of Fed Antigens from CX3CR1+ Macrophages to CD103+ Dendritic Cells

(2014) Elisa Mazzini et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells

(2014) I Vicente-Suarez et al.   Mucosal Immunology

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

(2014) Serge A. van de Pavert et al.   NATURE

Retinoic Acid and GM-CSF Coordinately Induce Retinal Dehydrogenase 2 (RALDH2) Expression through Cooperation between the RAR/RXR Complex and Sp1 in Dendritic Cells

(2014) Yoshiharu Ohoka et al.   PLoS One

Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

(2014) S. P. Spencer et al.   SCIENCE

All-trans retinoic acid attenuates airway inflammation by inhibiting Th2 and Th17 response in experimental allergic asthma

(2013) Jinhong Wu et al.   BMC IMMUNOLOGY

IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation

(2013) Emma K. Persson et al.   IMMUNITY

Luminal Bacteria Recruit CD103+ Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentation

(2013) Julia Farache et al.   IMMUNITY

Retinoic acid controls the homeostasis of pre-cDC–derived splenic and intestinal dendritic cells

(2013) Christopher A. Klebanoff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

(2013) Lisa A. Mielke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase in Lung CD103+ but Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T Cells and Promote Airway Tolerance

(2013) A. Khare et al.   JOURNAL OF IMMUNOLOGY

Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells

(2013) A Yokota-Nakatsuma et al.   Mucosal Immunology

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity

(2013) Bernardo Sgarbi Reis et al.   NATURE IMMUNOLOGY

Absorption of Vitamin A and Carotenoids by the Enterocyte: Focus on Transport Proteins

(2013) Emmanuelle Reboul   Nutrients

Retinoic acid-producing DCs and gut-tropic FOXP3+regulatory T cells in the induction of oral tolerance

(2013) Eduardo J. Villablanca   OncoImmunology

Epithelial Expression of the Cytosolic Retinoid Chaperone Cellular Retinol Binding Protein II Is Essential for in Vivo Imprinting of Local Gut Dendritic Cells by Lumenal Retinoids

(2012) Keely G. McDonald et al.   AMERICAN JOURNAL OF PATHOLOGY

Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis

(2012) S. H. Oehlers et al.   Disease Models & Mechanisms

Retinoic acids and hepatic stellate cells in liver disease

(2012) Young-Sun Lee et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells

(2012) R Zeng et al.   Mucosal Immunology

Oral tolerance to food protein

(2012) O Pabst et al.   Mucosal Immunology

Retinoic acid synthesis and functions in early embryonic development

(2012) Richard Kin Ting Kam et al.   Cell and Bioscience

MyD88 and Retinoic Acid Signaling Pathways Interact to Modulate Gastrointestinal Activities of Dendritic Cells

(2011) Eduardo J. Villablanca et al.   GASTROENTEROLOGY

Gut-Tropic T Cells That Express Integrin α4β7 and CCR9 Are Required for Induction of Oral Immune Tolerance in Mice

(2011) Barbara Cassani et al.   GASTROENTEROLOGY

Retinoic Acid Attenuates Ileitis by Restoring the Balance Between T-Helper 17 and T Regulatory Cells

(2011) Colm B. Collins et al.   GASTROENTEROLOGY

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

Prostaglandin E2 suppresses the differentiation of retinoic acid–producing dendritic cells in mice and humans

(2011) Angus Stock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MyD88-Dependent TLR1/2 Signals Educate Dendritic Cells with Gut-Specific Imprinting Properties

(2011) S. Wang et al.   JOURNAL OF IMMUNOLOGY

Hepatic Stellate Cells Function as Regulatory Bystanders

(2011) S. Ichikawa et al.   JOURNAL OF IMMUNOLOGY

Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance

(2011) Barbara Cassani et al.   MOLECULAR ASPECTS OF MEDICINE

Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

(2011) R. W. DePaolo et al.   NATURE

Vitamin A Metabolism: An Update

(2011) Diana N. D’Ambrosio et al.   Nutrients

Skin-draining lymph nodes contain dermis-derived CD103- dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells

(2010) M. Guilliams et al.   BLOOD

From carrot to clinic: an overview of the retinoic acid signaling pathway

(2010) Maria Theodosiou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generation of Mucosal Dendritic Cells from Bone Marrow Reveals a Critical Role of Retinoic Acid

(2010) T. Feng et al.   JOURNAL OF IMMUNOLOGY

Activation of  -Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine

(2010) S. Manicassamy et al.   SCIENCE

Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue Inducer-like Cells in Mucosal Immunity

(2009) Marco Colonna   IMMUNITY

Generation of gut-homing T cells and their localization to the small intestinal mucosa

(2009) William Agace   IMMUNOLOGY LETTERS

GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity

(2009) Aya Yokota et al.   INTERNATIONAL IMMUNOLOGY

Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning

(2009) I D Iliev et al.   Mucosal Immunology

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

(2009) Serge A van de Pavert et al.   NATURE IMMUNOLOGY

Expression of RALDHs (ALDH1As) and CYP26s in human tissues and during the neural differentiation of P19 embryonal carcinoma stem cell

(2008) Jinlei Xi et al.   GENE EXPRESSION PATTERNS

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

(2008) Jonathan A. Hill et al.   IMMUNITY

Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo

(2008) Swantje I. Hammerschmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE