Collaborative Action of Toll-Like and Nod-Like Receptors as Modulators of the Inflammatory Response to Pathogenic Bacteria

Investigating the Role of Nucleotide-Binding Oligomerization Domain–Like Receptors in Bacterial Lung Infection

(2014) Mary Leissinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pseudomonas aeruginosaType-3 Secretion System Dampens Host Defense by Exploiting the NLRC4-coupled Inflammasome

(2014) Emmanuel Faure et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection

(2014) Majid Sakhi Jabir et al.   Cell Host & Microbe

Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection

(2014) R. Fang et al.   INFECTION AND IMMUNITY

Cross-Tolerization between Nod1 and Nod2 Signaling Results in Reduced Refractoriness to Bacterial Infection in Nod2-Deficient Macrophages

(2014) Y.-G. Kim et al.   JOURNAL OF IMMUNOLOGY

Double-Stranded RNA Induces an Antiviral Defense Status in Epidermal Keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-Mediated Differential Signaling

(2014) B. N. Kalali et al.   JOURNAL OF IMMUNOLOGY

Critical role for the AIM2 inflammasome during acute CNS bacterial infection

(2014) Richa Hanamsagar et al.   JOURNAL OF NEUROCHEMISTRY

Expression of Toll-Like Receptors 3, 7, and 9 in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus

(2014) Agnieszka Klonowska-Szymczyk et al.   MEDIATORS OF INFLAMMATION

Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection

(2014) S. M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interplay between microRNAs and host pathogen recognition receptors (PRRs) signaling pathways in response to viral infection

(2014) Ao Zhou et al.   VIRUS RESEARCH

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

(2014) Xiaobing He et al.   Biomed Research International

Nucleotide-binding oligomerization domain containing-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) regulates intrapulmonary replication of aerosolized Legionella pneumophila

(2013) William R Berrington et al.   BMC INFECTIOUS DISEASES

Combined Action of Nucleic Acid-Sensing Toll-like Receptors and TLR11/TLR12 Heterodimers Imparts Resistance to Toxoplasma gondii in Mice

(2013) Warrison A. Andrade et al.   Cell Host & Microbe

Of inflammasomes and pathogens - sensing of microbes by the inflammasome

(2013) Franz Bauernfeind et al.   EMBO Molecular Medicine

The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production inHelicobacter pyloriinfected dendritic cells

(2013) Dong-Jae Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

Combined Stimulation of Toll-Like Receptor 5 and NOD1 Strongly Potentiates Activity of NF-κB, Resulting in Enhanced Innate Immune Reactions and Resistance to Salmonella enterica Serovar Typhimurium Infection

(2013) Amir I. Tukhvatulin et al.   INFECTION AND IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

Expression of Toll-like receptor 9 in mouse and human lungs

(2013) David Schneberger et al.   JOURNAL OF ANATOMY

Repression of Inflammasome by Francisella tularensis during Early Stages of Infection

(2013) Rachel J. Dotson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of TLR10 as a Key Mediator of the Inflammatory Response to Listeria monocytogenes in Intestinal Epithelial Cells and Macrophages

(2013) T. Regan et al.   JOURNAL OF IMMUNOLOGY

The AIM2 Inflammasome Is Involved in Macrophage Activation During Infection With Virulent Mycobacterium bovis Strain

(2013) Yang Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Increased toll-like receptor 4 in cerebral endothelial cells contributes to the astrocyte swelling and brain edema in acute hepatic encephalopathy

(2013) Arumugam R. Jayakumar et al.   JOURNAL OF NEUROCHEMISTRY

Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells

(2013) I. Ioannidis et al.   JOURNAL OF VIROLOGY

NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease

(2013) Alexander D. Radian et al.   MICROBES AND INFECTION

NLRP6 in infection and inflammation

(2013) Paras K. Anand et al.   MICROBES AND INFECTION

Characterization of NLRP12 during the In Vivo Host Immune Response to Klebsiella pneumoniae and Mycobacterium tuberculosis

(2013) Irving C. Allen et al.   PLoS One

Innate Immune Receptors in Human Airway Smooth Muscle Cells: Activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 Agonists

(2013) Anne Månsson Kvarnhammar et al.   PLoS One

Gram-Positive Bacterial Lipoglycans Based on a Glycosylated Diacylglycerol Lipid Anchor Are Microbe-Associated Molecular Patterns Recognized by TLR2

(2013) Landry Blanc et al.   PLoS One

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

NOD-Like Receptors in Lung Diseases

(2013) Catherine Chaput et al.   Frontiers in Immunology

Pyrin- and CARD-only Proteins as Regulators of NLR Functions

(2013) Hongnga T. Le et al.   Frontiers in Immunology

Cutting-Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan-Induced Trophoblast Apoptosis

(2012) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Tolerance of Infections

(2012) Janelle S. Ayres et al.   Annual Review of Immunology

Interferon Regulatory Factor 5 in the Pathogenesis of Systemic Lupus Erythematosus

(2012) Candace M. Cham et al.   Clinical & Developmental Immunology

Muramyl dipeptide mediated activation of human bronchial epithelial cells interacting with basophils: a novel mechanism of airway inflammation

(2012) H. N. Qiu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Recognition of bacterial infection by innate immune sensors

(2012) Sushil Kumar et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Nod-like receptors in intestinal host defense

(2012) Susan J. Robertson et al.   CURRENT OPINION IN GASTROENTEROLOGY

Age-related changes in expression and function of Toll-like receptors in human skin

(2012) N. Iram et al.   DEVELOPMENT

Recognition of fungal RNA by TLR7 has a nonredundant role in host defense against experimental candidiasis

(2012) Carmelo Biondo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages

(2012) Sonal Khare et al.   IMMUNITY

Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

(2012) A. Alicia Koblansky et al.   IMMUNITY

TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2

(2012) Harald Schwarz et al.   IMMUNOBIOLOGY

NOD2 Signaling Contributes to Host Defense in the Lungs against Escherichia coli Infection

(2012) Balamayooran Theivanthiran et al.   INFECTION AND IMMUNITY

Critical role of AIM2 in Mycobacterium tuberculosis infection

(2012) H. Saiga et al.   INTERNATIONAL IMMUNOLOGY

The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter

(2012) Jeremy A. Hirota et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intracellular Staphylococcus aureus-induced NF-κB activation and proinflammatory responses of P815 cells are mediated by NOD2

(2012) Xuhua Xie et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

(2012) F A Carvalho et al.   Mucosal Immunology

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

(2012) Paras K. Anand et al.   NATURE

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

(2012) Jun Cui et al.   NATURE IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Rac1 Regulates the NLRP3 Inflammasome Which Mediates IL-1beta Production in Chlamydophila pneumoniae Infected Human Mononuclear Cells

(2012) Julia Eitel et al.   PLoS One

NOD1 Cooperates with TLR2 to Enhance T Cell Receptor-Mediated Activation in CD8 T Cells

(2012) Blandine C. Mercier et al.   PLoS One

Balancing resistance and infection tolerance through metabolic means

(2012) M. C. Chambers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells

(2011) Kamila Belhocine et al.   CELLULAR MICROBIOLOGY

NOD-like receptors and the innate immune system: Coping with danger, damage and death

(2011) Kristof Kersse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation

(2011) Birte Zurek et al.   Innate Immunity

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice

(2011) Kimberly M. Davis et al.   JOURNAL OF CLINICAL INVESTIGATION

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-  Signaling

(2011) C. Bourgeois et al.   JOURNAL OF IMMUNOLOGY

NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1

(2011) N. Jounai et al.   JOURNAL OF IMMUNOLOGY

Lipoglycans Contribute to Innate Immune Detection of Mycobacteria

(2011) Shyam Krishna et al.   PLoS One

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Klebsiella pneumoniae subverts the activation of inflammatory responses in a NOD1-dependent manner

(2010) Verónica Regueiro et al.   CELLULAR MICROBIOLOGY

What is new with Nods?

(2010) Joao G Magalhaes et al.   CURRENT OPINION IN IMMUNOLOGY

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

(2010) Sarah Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila

(2010) William R. Berrington et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natural Staphylococcus aureus-derived peptidoglycan fragments activate NOD2 and act as potent costimulators of the innate immune system exclusively in the presence of TLR signals

(2010) Thomas Volz et al.   FASEB JOURNAL

Nod1 and Nod2 Regulation of Inflammation in the Salmonella Colitis Model

(2010) K. Geddes et al.   INFECTION AND IMMUNITY

Cooperation between Multiple Microbial Pattern Recognition Systems Is Important for Host Protection against the Intracellular Pathogen Legionella pneumophila

(2010) K. A. Archer et al.   INFECTION AND IMMUNITY

Role for toll-like receptors in autoimmune disease: The example of systemic lupus erythematosus

(2010) Christophe Richez et al.   JOINT BONE SPINE

Innate Immune Detection of Bacterial Virulence Factors Via the NLRC4 Inflammasome

(2010) Edward A. Miao et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Sensing Cytoplasmic Danger Signals by the Inflammasome

(2010) Emad S. Alnemri   JOURNAL OF CLINICAL IMMUNOLOGY

Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes

(2010) Jianghong Wu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity

(2010) J. C. Arthur et al.   JOURNAL OF IMMUNOLOGY

Pathogenic Vibrio Activate NLRP3 Inflammasome via Cytotoxins and TLR/Nucleotide-Binding Oligomerization Domain-Mediated NF- B Signaling

(2010) C. Toma et al.   JOURNAL OF IMMUNOLOGY

Differential Regulation of Caspase-1 Activation via NLRP3/NLRC4 Inflammasomes Mediated by Aerolysin and Type III Secretion System during Aeromonas veronii Infection

(2010) A. J. McCoy et al.   JOURNAL OF IMMUNOLOGY

Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes

(2010) K. Tsuchiya et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2

(2010) S. E. Warren et al.   JOURNAL OF IMMUNOLOGY

Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia

(2010) Ronan Kapetanovic et al.   MICROBES AND INFECTION

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

(2010) Najwane Saïd-Sadier et al.   PLoS One

Staphylococcal Peptidoglycan Co-Localizes with Nod2 and TLR2 and Activates Innate Immune Response via Both Receptors in Primary Murine Keratinocytes

(2010) Maria Anna Müller-Anstett et al.   PLoS One

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection

(2010) Fredric Carlsson et al.   PLoS Pathogens

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pathogen recognition in the innate immune response

(2009) Himanshu Kumar et al.   BIOCHEMICAL JOURNAL

Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

(2009) Maria Kaparakis et al.   CELLULAR MICROBIOLOGY

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

(2009) Mathieu J.M. Bertrand et al.   IMMUNITY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Kinase Activity of Rip2 Determines Its Stability and Consequently Nod1- and Nod2-mediated Immune Responses

(2009) Chiara Nembrini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergism between TLRs and NOD1/2 in Oral Epithelial Cells

(2009) A. Uehara et al.   JOURNAL OF DENTAL RESEARCH

Blimp-1/PRDM1 Mediates Transcriptional Suppression of the NLR Gene NLRP12/Monarch-1

(2009) C. A. Lord et al.   JOURNAL OF IMMUNOLOGY

Listeria monocytogenes-Infected Human Peripheral Blood Mononuclear Cells Produce IL-1 , Depending on Listeriolysin O and NLRP3

(2009) K. Meixenberger et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

(2009) R. Munoz-Planillo et al.   JOURNAL OF IMMUNOLOGY

Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism

(2009) C. C. Allison et al.   JOURNAL OF IMMUNOLOGY

The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis

(2009) E C Lavelle et al.   Mucosal Immunology

The NOD/RIP2 Pathway Is Essential for Host Defenses Against Chlamydophila pneumoniae Lung Infection

(2009) Kenichi Shimada et al.   PLoS Pathogens

Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium

(2008) Jonathan L. Koff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Adding fuel to fire: microRNAs as a new class of mediators of inflammation

(2008) F J Sheedy et al.   ANNALS OF THE RHEUMATIC DISEASES

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls

(2008) Lilian O. Moreira et al.   CELLULAR MICROBIOLOGY

Role of Toll-Like Receptors in Immune Responses to Chlamydial Infections

(2008) Xi Yang et al.   CURRENT PHARMACEUTICAL DESIGN

Toll-Like Receptor Signaling in Small Intestinal Epithelium Promotes B-Cell Recruitment and IgA Production in Lamina Propria

(2008) Limin Shang et al.   GASTROENTEROLOGY

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

(2008) Ulrich Zähringer et al.   IMMUNOBIOLOGY

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

(2008) Maria A Ermolaeva et al.   NATURE IMMUNOLOGY

Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?

(2008) Tieu-Lan Chau et al.   TRENDS IN BIOCHEMICAL SCIENCES