Switching Off Key Signaling Survival Molecules to Switch On the Resolution of Inflammation

Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway

(2014) Liu Yi et al.   CANCER SCIENCE

Phase II Trial of Mapatumumab, a Fully Human Agonist Monoclonal Antibody to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 1 (TRAIL-R1), in Combination With Paclitaxel and Carboplatin in Patients With Advanced Non–Small-Cell Lung Cancer

(2014) Joachim von Pawel et al.   Clinical Lung Cancer

Discovery of 2-methoxy-3-phenylsulfonamino-5-(quinazolin-6-yl or quinolin-6-yl)benzamides as novel PI3K inhibitors and anticancer agents by bioisostere

(2014) Teng Shao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress

(2014) Chia-Jung Yu et al.   Journal of Proteomics

Tumor necrosis factor-related apoptosis-inducing ligand mediates the resolution of allergic airway inflammation induced by chronic allergen inhalation

(2014) L Faustino et al.   Mucosal Immunology

Amelioration of Severe TNBS Induced Colitis by Novel AP-1 and NF-κB Inhibitors in Rats

(2014) Magdy El-Salhy et al.   TheScientificWorldJOURNAL

Esophageal cancer-selective expression of TRAIL mediated by MREs of miR-143 and miR-122

(2014) Kun Zhou et al.   TUMOR BIOLOGY

Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP

(2014) W-C Lin et al.   Cell Death & Disease

Inhibition of NF-κB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation

(2013) Ryo Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SC-514, a selective inhibitor of IKKβ attenuates RANKL-induced osteoclastogenesis and NF-κB activation

(2013) Qian Liu et al.   BIOCHEMICAL PHARMACOLOGY

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

(2013) Ha-Na Lee et al.   BIOCHEMICAL PHARMACOLOGY

Local apoptosis mediates clearance of macrophages from resolving inflammation in mice

(2013) E. L. Gautier et al.   BLOOD

TRAIL receptor agonist conatumumab with modified FOLFOX6 plus bevacizumab for first-line treatment of metastatic colorectal cancer

(2013) Charles S. Fuchs et al.   CANCER

Pathophysiological roles of nuclear factor kappaB (NF-kB) in pulmonary arterial hypertension: effects of synthetic selective NF-kB inhibitor IMD-0354

(2013) Susumu Hosokawa et al.   CARDIOVASCULAR RESEARCH

Pharmacological strategies to resolve acute inflammation

(2013) Lirlândia Pires Sousa et al.   CURRENT OPINION IN PHARMACOLOGY

Death receptor agonist therapies for cancer, which is the right TRAIL?

(2013) Pamela M. Holland   CYTOKINE & GROWTH FACTOR REVIEWS

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Glucocorticoid Protection Against Myocardial Ischemia-Reperfusion Injury

(2013) János G. Filep   HYPERTENSION

Quercetin-3-O-(2″-galloyl)-α-l-rhamnopyranoside inhibits TNF-α-activated NF-κB-induced inflammatory mediator production by suppressing ERK activation

(2013) Chung Soo Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hydrogen Peroxide as a Damage Signal in Tissue Injury and Inflammation: Murderer, Mediator, or Messenger?

(2013) Albert van der Vliet et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Shaping the Murine Macrophage Phenotype: IL-4 and Cyclic AMP Synergistically Activate the Arginase I Promoter

(2013) K. E. Sheldon et al.   JOURNAL OF IMMUNOLOGY

Proresolving and Tissue-Protective Actions of Annexin A1-Based Cleavage-Resistant Peptides Are Mediated by Formyl Peptide Receptor 2/Lipoxin A4 Receptor

(2013) J. Dalli et al.   JOURNAL OF IMMUNOLOGY

MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop

(2013) K. F. MacKenzie et al.   MOLECULAR AND CELLULAR BIOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Regulation of the CRL4Cdt2 Ubiquitin Ligase and Cell-Cycle Exit by the SCFFbxo11 Ubiquitin Ligase

(2013) Mario Rossi et al.   MOLECULAR CELL

Resolution of inflammation: Mechanisms and opportunity for drug development

(2013) Ana L. Alessandri et al.   PHARMACOLOGY & THERAPEUTICS

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitor of nuclear factor-κB, SN50, attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model

(2013) Chih-Feng Chian et al.   Translational Research

Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation

(2012) A E Leitch et al.   CELL DEATH AND DIFFERENTIATION

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

MicroRNAs, new effectors and regulators of NF-κB

(2012) Mark P. Boldin et al.   IMMUNOLOGICAL REVIEWS

Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair

(2012) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

TRAIL: not just for tumors anymore?

(2012) Chris A. Benedict et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice

(2012) Kathrin Steinwede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis

(2012) Juliana P. Vago et al.   JOURNAL OF LEUKOCYTE BIOLOGY

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(2012) Arie Hoogendijk et al.   MOLECULAR MEDICINE

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Therapeutic effect of SN50, an inhibitor of nuclear factor-κB, in treatment of TBI in mice

(2012) Yu-Xia Sun et al.   NEUROLOGICAL SCIENCES

Dacarbazine and the Agonistic TRAIL Receptor-2 Antibody Lexatumumab Induce Synergistic Anticancer Effects in Melanoma

(2012) Birgit Engesæter et al.   PLoS One

Emerging roles for lysophosphatidylserine in resolution of inflammation

(2012) S. Courtney Frasch et al.   PROGRESS IN LIPID RESEARCH

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

(2012) Emmet E McGrath et al.   THORAX

Emerging Roles of Eosinophils and Eosinophil-Derived Lipid Mediators in the Resolution of Inflammation

(2012) Yosuke Isobe et al.   Frontiers in Immunology

New Lives Given by Cell Death: Macrophage Differentiation Following Their Encounter with Apoptotic Leukocytes during the Resolution of Inflammation

(2012) Amiram Ariel et al.   Frontiers in Immunology

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

(2011) D. Mahadevan et al.   ANNALS OF ONCOLOGY

Resolution of neutrophilic inflammation by H2O2 in antigen-induced arthritis

(2011) Fernando Lopes et al.   ARTHRITIS AND RHEUMATISM

Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow

(2011) Jesmond Dalli et al.   FASEB JOURNAL

Signaling via Macrophage G2A Enhances Efferocytosis of Dying Neutrophils by Augmentation of Rac Activity

(2011) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of Annexin A1 by ADAM10 during Secondary Necrosis Generates a Monocytic "Find-Me" Signal

(2011) K. E. Blume et al.   JOURNAL OF IMMUNOLOGY

Editorial: Neutrophil apoptosis: hot on the TRAIL of inflammatory resolution

(2011) Andrew E. Leitch et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

(2011) Emmet E. McGrath et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms of Drug Sensitization to TRA-8, an Agonistic Death Receptor 5 Antibody, Involve Modulation of the Intrinsic Apoptotic Pathway in Human Breast Cancer Cells

(2011) H. M. Amm et al.   MOLECULAR CANCER RESEARCH

Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells

(2011) C Jennewein et al.   ONCOGENE

Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2

(2011) Y Li et al.   ONCOGENE

Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

(2011) Ana L. Alessandri et al.   PLoS One

MicroRNAs in NF- B signaling

(2011) X. Ma et al.   Journal of Molecular Cell Biology

Protective effects of prostaglandin E1 on human umbilical vein endothelial cell injury induced by hydrogen peroxide

(2010) Wen-tong Fang et al.   ACTA PHARMACOLOGICA SINICA

Glutathione reductase plays an anti-apoptotic role against oxidative stress in human hepatoma cells

(2010) Su-Jung Kim et al.   BIOCHIMIE

Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature

(2010) M. Pederzoli-Ribeil et al.   BLOOD

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling

(2010) Danute Pupjalis et al.   EMBO Molecular Medicine

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

(2010) Andrew E. Leitch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

WITHDRAWN BY AUTHOR: Heat shock protein 70 interacts with nucleolin and inhibits its cleavage, down-regulation and apoptosis induced by hydrogen peroxide in myocytes

(2010) K. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice

(2010) Remo C. Russo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-κB-independent manner

(2010) Lirlândia P. Sousa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hydrogen Peroxide as a Cell-Survival Signaling Molecule

(2009) Gillian Groeger et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury

(2009) Katrin Schuh et al.   BIOCHEMICAL PHARMACOLOGY

Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-κB

(2009) Lirlândia P. Sousa et al.   BIOCHEMICAL PHARMACOLOGY

Playing the DISC: Turning on TRAIL death receptor-mediated apoptosis in cancer

(2009) Bodvaël Pennarun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

(2009) AE Leitch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging role of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) as a key regulator of inflammatory responses

(2009) Adam Collison et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

(2009) Rodger Duffin et al.   FEBS LETTERS

The resolution of inflammation: Anti-inflammatory roles for NF-κB

(2009) Toby Lawrence et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Nonresolving Inflammation in gp91phox-/- Mice, a Model of Human Chronic Granulomatous Disease, Has Lower Adenosine and Cyclic Adenosine 5'-Monophosphate

(2009) R. Rajakariar et al.   JOURNAL OF IMMUNOLOGY

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin

(2009) Fábio Klamt et al.   NATURE CELL BIOLOGY

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

Cooperation of the Agonistic DR5 Antibody Apomab with Chemotherapy to Inhibit Orthotopic Lung Tumor Growth and Improve Survival

(2008) H. Jin et al.   CLINICAL CANCER RESEARCH

NADPH Oxidase-dependent Generation of Lysophosphatidylserine Enhances Clearance of Activated and Dying Neutrophils via G2A

(2008) S. Courtney Frasch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A critical role for TRAIL in resolution of granulomatous experimental autoimmune thyroiditis

(2008) Y Fang et al.   JOURNAL OF PATHOLOGY