Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS

Ebola virus (EBOV) infection: Therapeutic strategies

(2015) Erik De Clercq   BIOCHEMICAL PHARMACOLOGY

Hydroxychloroquine and Chloroquine Retinopathy

(2015) Adrian C. Tsang et al.   OPHTHALMOLOGY

Influence of quinacrine and chloroquine on the in vitro 3′-azido-3′-deoxythymidine antiretroviral effect

(2015) Klintsy J Torres et al.   AIDS Research and Therapy

Evaluation of Ebola Virus Inhibitors for Drug Repurposing

(2015) Peter B. Madrid et al.   ACS Infectious Diseases

Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture

(2014) Adriaan H. de Wilde et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus ReactivationIn Vitro

(2014) Christina Gavegnano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Assessment of chloroquine as a modulator of immune activation to improve CD4 recovery in immune nonresponding HIV-infected patients receiving antiretroviral therapy

(2014) J-P Routy et al.   HIV MEDICINE

Impaired Restoration of Plasmacytoid Dendritic Cells in HIV-1-Infected Patients with Poor CD4 T Cell Reconstitution Is Associated with Decrease in Capacity to Produce IFN-  but Not Proinflammatory Cytokines

(2014) N. Sachdeva et al.   JOURNAL OF IMMUNOLOGY

Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

(2014) A. Saez-Cirion et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Plasmodium infection reduces the volume of the viral reservoir in SIV-infected rhesus macaques receiving antiretroviral therapy

(2014) Xiao-Yong Zhan et al.   Retrovirology

Persistent immune activation in chronic HIV infection

(2013) Reena Rajasuriar et al.   AIDS

Transient Increase of Interferon-Stimulated Genes and No Clinical Benefit by Chloroquine Treatment During Acute Simian Immunodeficiency Virus Infection of Macaques

(2013) Monica Vaccari et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Modulation of HIV-1-Induced Activation of Plasmacytoid Dendritic Cells by 6-Desfluoroquinolones

(2013) Caroline M. Royle et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Microbial Translocation in the Pathogenesis of HIV Infection and AIDS

(2013) Giulia Marchetti et al.   CLINICAL MICROBIOLOGY REVIEWS

HIV-associated chronic immune activation

(2013) Mirko Paiardini et al.   IMMUNOLOGICAL REVIEWS

Immune activation and HIV persistence: implications for curative approaches to HIV infection

(2013) Nichole R. Klatt et al.   IMMUNOLOGICAL REVIEWS

Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells

(2013) Jorg van Loosdregt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents

(2013) Peter B. Madrid et al.   PLoS One

Investigational treatment suspension and enhanced cell-mediated immunity at rebound followed by drug-free remission of simian AIDS

(2013) Iart Shytaj et al.   Retrovirology

A cure for AIDS: a matter of timing?

(2013) Iart Shytaj et al.   Retrovirology

A candidate anti-HIV reservoir compound, auranofin, exerts a selective ‘anti-memory’ effect by exploiting the baseline oxidative status of lymphocytes

(2013) B Chirullo et al.   Cell Death & Disease

Immune activation and HIV persistence

(2013) Hiroyu Hatano   Current Opinion in HIV and AIDS

Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques

(2012) Jian-Ping Ma et al.   Cellular & Molecular Immunology

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

(2012) Liang Shan et al.   IMMUNITY

Effects of Hydroxychloroquine on Immune Activation and Disease Progression Among HIV-Infected Patients Not Receiving Antiretroviral Therapy

(2012) Nicholas I. Paton et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

(2011) Mark G. Lewis et al.   AIDS

Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection

(2011) Gregor F Lichtfuss et al.   Biomarkers in Medicine

Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders

(2011) S. Piconi et al.   BLOOD

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

(2011) Mirko Paiardini et al.   NATURE MEDICINE

Short Communication: Preferential Concentration of Hydroxychloroquine in Adenoid Tissue of HIV-Infected Subjects

(2010) Lucinda Aguirre-Cruz et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection

(2010) S. M. Murray et al.   JOURNAL OF VIROLOGY

Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV

(2010) Nicolas Chomont et al.   Current Opinion in HIV and AIDS

Chloroquine Modulates HIV-1-Induced Plasmacytoid Dendritic Cell Alpha Interferon: Implication for T-Cell Activation

(2009) J. A. Martinson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy

(2009) Libin Rong et al.   PLoS Computational Biology

Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120

(2008) A. Forsman et al.   JOURNAL OF VIROLOGY

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

(2008) Judith N Mandl et al.   NATURE MEDICINE

Relationship between T Cell Activation and CD4+T Cell Count in HIV‐Seropositive Individuals with Undetectable Plasma HIV RNA Levels in the Absence of Therapy

(2007) Peter W. Hunt et al.   JOURNAL OF INFECTIOUS DISEASES