Extending the “One Strain Many Compounds” (OSMAC) Principle to Marine Microorganisms

Genome-scale biological models for industrial microbial systems

(2018) Nan Xu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An enhanced genome-scale metabolic reconstruction of Streptomyces clavuligerus identifies novel strain improvement strategies

(2018) León Toro et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Microbioreactor Systems for Accelerated Bioprocess Development

(2018) Johannes Hemmerich et al.   Biotechnology Journal

Production and Identification of Inthomycin B Produced by a Deep-Sea Sediment-Derived Streptomyces sp. YB104 Based on Cultivation-Dependent Approach

(2018) Qihao Wu et al.   CURRENT MICROBIOLOGY

Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms

(2018) Emilia Palazzotto et al.   CURRENT OPINION IN MICROBIOLOGY

Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium

(2018) Shotaro Hoshino et al.   JOURNAL OF ANTIBIOTICS

Effects of flask configuration on biofilm growth and metabolites of intertidal Cyanobacteria isolated from a mangrove forest

(2018) M. Veerabadhran et al.   JOURNAL OF APPLIED MICROBIOLOGY

Coculture of Two Developmental Stages of a Marine-Derived Aspergillus alliaceus Results in the Production of the Cytotoxic Bianthrone Allianthrone A

(2018) P. E. Mandelare et al.   JOURNAL OF NATURAL PRODUCTS

Optimization of culture conditions for penicilazaphilone C production by a marine-derived fungus Penicillium sclerotiorum M-22

(2018) H.-G. Zhao et al.   LETTERS IN APPLIED MICROBIOLOGY

Optimum Production Conditions, Purification, Identification, and Antioxidant Activity of Violaxanthin from Microalga Eustigmatos cf. polyphem (Eustigmatophyceae)

(2018) Feifei Wang et al.   Marine Drugs

Raistrickiones A−E from a Highly Productive Strain of Penicillium raistrickii Generated through Thermo Change

(2018) De-Sheng Liu et al.   Marine Drugs

The secreted metabolome ofStreptomyces chartreusisand implications for bacterial chemistry

(2018) Christoph H. R. Senges et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytotoxic cytochalasans from Aspergillus flavipes PJ03-11 by OSMAC method

(2018) Yingying Si et al.   TETRAHEDRON LETTERS

First identification of marine diatoms with anti-tuberculosis activity

(2018) Chiara Lauritano et al.   Scientific Reports

Microbioreactor Systems for Accelerated Bioprocess Development

(2018) Johannes Hemmerich et al.   Biotechnology Journal

Target Confinement in Small Reaction Volumes Using Microfluidic Technologies: A Smart Approach for Single-Entity Detection and Analysis

(2018) Karen Ven et al.   ACS Sensors

luxR Homolog-Linked Biosynthetic Gene Clusters in Proteobacteria

(2018) Carolyn A. Brotherton et al.   mSystems

Ecology and Biotechnological Potential of Bacteria Belonging to the Genus Pseudovibrio

(2018) Stefano Romano   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Ecological implications of hypoxia-triggered shifts in secondary metabolism

(2017) Kelley A. Gallagher et al.   ENVIRONMENTAL MICROBIOLOGY

Unique prostate cancer-toxic polyketides from marine sediment-derived fungus Isaria felina

(2017) Olga F Smetanina et al.   JOURNAL OF ANTIBIOTICS

Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes

(2017) Hiroyasu Onaka   JOURNAL OF ANTIBIOTICS

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis

(2017) Juan F Martín et al.   JOURNAL OF ANTIBIOTICS

Inducing Secondary Metabolite Production by Combined Culture of Talaromyces aculeatus and Penicillium variabile

(2017) Zhenzhen Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Chaunopyran A: Co-Cultivation of Marine Mollusk-Derived Fungi Activates a Rare Class of 2-Alkenyl-Tetrahydropyran

(2017) Zhuo Shang et al.   JOURNAL OF NATURAL PRODUCTS

Upregulation and Identification of Antibiotic Activity of a Marine-Derived Streptomyces sp. via Co-Cultures with Human Pathogens

(2017) Anne Sung et al.   Marine Drugs

Does Osmotic Stress Affect Natural Product Expression in Fungi?

(2017) David Overy et al.   Marine Drugs

Establishing the Secondary Metabolite Profile of the Marine Fungus: Tolypocladium geodes sp. MF458 and Subsequent Optimisation of Bioactive Secondary Metabolite Production

(2017) Bethlehem Kebede et al.   Marine Drugs

A Novel Benzoquinone Compound Isolated from Deep-Sea Hydrothermal Vent Triggers Apoptosis of Tumor Cells

(2017) et al.   Marine Drugs

Symbiosis-inspired approaches to antibiotic discovery

(2017) Navid Adnani et al.   NATURAL PRODUCT REPORTS

Retrospective analysis of natural products provides insights for future discovery trends

(2017) Cameron R. Pye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of cryptic bioactive 2,5-diketopiperazines in fungus Penicillium sp. DT-F29 by microbial co-culture

(2017) Liyan Yu et al.   TETRAHEDRON

Novel mechanism of metabolic co-regulation coordinates the biosynthesis of secondary metabolites in Pseudomonas protegens

(2017) Qing Yan et al.   eLife

Strategies for Fermentation Medium Optimization: An In-Depth Review

(2017) Vineeta Singh et al.   Frontiers in Microbiology

Phosphate Limitation Triggers the Dissolution of Precipitated Iron by the Marine Bacterium Pseudovibrio sp. FO-BEG1

(2017) Stefano Romano et al.   Frontiers in Microbiology

Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation

(2017) Jennifer Wakefield et al.   Frontiers in Microbiology

Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds

(2017) Lynn M. Naughton et al.   Frontiers in Microbiology

Isolation, identification, optimization, and metabolite profiling of Streptomyces sparsus VSM-30

(2017) Ushakiranmayi Managamuri et al.   3 Biotech

Isolation, identification, optimization, and metabolite profiling of Streptomyces sparsus VSM-30

(2017) Ushakiranmayi Managamuri et al.   3 Biotech

Growth on Chitin Impacts the Transcriptome and Metabolite Profiles of Antibiotic-Producing Vibrio coralliilyticus S2052 and Photobacterium galatheae S2753

(2017) Sonia Giubergia et al.   mSystems

Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens

(2017) Paul G. Beyersmann et al.   Scientific Reports

Influence of Niche-Specific Nutrients on Secondary Metabolism in Vibrionaceae

(2016) Sonia Giubergia et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Stress-driven discovery of a cryptic antibiotic produced by Streptomyces sp. WU20 from Kueishantao hydrothermal vent with an integrated metabolomics strategy

(2016) Yutong Shi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Screening applications in drug discovery based on microfluidic technology

(2016) P. Eribol et al.   Biomicrofluidics

New Diorcinol J Produced by Co-Cultivation of Marine Fungi Aspergillus sulphureus and Isaria felina

(2016) O. I. Zhuravleva et al.   CHEMISTRY OF NATURAL COMPOUNDS

Physiological and transcriptional responses to inorganic nutrition in a tropical Pacific strain of Alexandrium minutum: Implications for the saxitoxin genes and toxin production

(2016) Kieng Soon Hii et al.   HARMFUL ALGAE

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Copper and Manganese Cations Alter Secondary Metabolism in the FungusPenicillium brasilianum

(2016) Taícia Pacheco Fil et al.   JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY

Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds

(2016) Anak Indraningrat et al.   Marine Drugs

Induced production of cytochalasans in co-culture of marine fungusAspergillus flavipesand actinomyceteStreptomycessp.

(2016) Liyan Yu et al.   NATURAL PRODUCT RESEARCH

Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method

(2016) Wen-Cai Liu et al.   Phytochemistry Letters

Activity-Independent Discovery of Secondary Metabolites Using Chemical Elicitation and Cheminformatic Inference

(2015) Sheila M. Pimentel-Elardo et al.   ACS Chemical Biology

Phosphate Limitation Induces Drastic Physiological Changes, Virulence-Related Gene Expression, and Secondary Metabolite Production in Pseudovibrio sp. Strain FO-BEG1

(2015) Stefano Romano et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhanced biofilm formation and melanin synthesis by the oyster settlement-promotingShewanella colwellianais related to hydrophobic surface and simulated intertidal environment

(2015) Sayani Mitra et al.   BIOFOULING

Changes in secondary metabolic profiles of Microcystis aeruginosa strains in response to intraspecific interactions

(2015) Enora Briand et al.   ENVIRONMENTAL MICROBIOLOGY

Light and temperature effects on bioactivity in diatoms

(2015) Richard A. Ingebrigtsen et al.   JOURNAL OF APPLIED PHYCOLOGY

Induced Production of Halogenated Epidithiodiketopiperazines by a Marine-Derived Trichoderma cf. brevicompactum with Sodium Halides

(2015) Hiroyuki Yamazaki et al.   JOURNAL OF NATURAL PRODUCTS

Penicyclones A–E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp. F23-2

(2015) Wenqiang Guo et al.   JOURNAL OF NATURAL PRODUCTS

Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor

(2015) Xueqian He et al.   JOURNAL OF NATURAL PRODUCTS

Investigation of Interspecies Interactions within Marine Micromonosporaceae Using an Improved Co-Culture Approach

(2015) Navid Adnani et al.   Marine Drugs

The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms

(2015) F. Reen et al.   Marine Drugs

LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola

(2015) Utpal Bose et al.   Marine Drugs

Biological Activity of Recently Discovered Halogenated Marine Natural Products

(2015) Gordon Gribble   Marine Drugs

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

(2015) Laura V. Flórez et al.   NATURAL PRODUCT REPORTS

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

A new fusarielin analogue from Penicillium sp. isolated from the Mediterranean sponge Ircinia oros

(2015) Huiqin Chen et al.   TETRAHEDRON LETTERS

A bioinformatic survey of distribution, conservation, and probable functions of LuxR solo regulators in bacteria

(2015) Sujatha Subramoni et al.   Frontiers in Cellular and Infection Microbiology

The Pho regulon: a huge regulatory network in bacteria

(2015) Fernando Santos-Beneit   Frontiers in Microbiology

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

(2015) Tina Netzker et al.   Frontiers in Microbiology

Natural Combinatorial Biosynthesis Involving Two Clusters for the Synthesis of Three Pyrrolamides in Streptomyces netropsis

(2014) Audrey Vingadassalon et al.   ACS Chemical Biology

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

(2014) Peter Cimermancic et al.   CELL

Effects of salinity on antibiotic production in sponge-derivedSalinisporaactinobacteria

(2014) Y.K. Ng et al.   JOURNAL OF APPLIED MICROBIOLOGY

Eleganketal A, a Highly Oxygenated Dibenzospiroketal from the Marine-Derived Fungus Spicaria elegans KLA03

(2014) Yepeng Luan et al.   JOURNAL OF NATURAL PRODUCTS

Caryophyllene Sesquiterpenes from the Marine-Derived Fungus Ascotricha sp. ZJ-M-5 by the One Strain–Many Compounds Strategy

(2014) Wen-Jing Wang et al.   JOURNAL OF NATURAL PRODUCTS

Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163

(2014) Yousef Dashti et al.   Marine Drugs

Zn-Driven Discovery of a Hydrothermal Vent Fungal Metabolite Clavatustide C, and an Experimental Study of the Anti-Cancer Mechanism of Clavatustide B

(2014) Panpan Ye et al.   Marine Drugs

Phenolic Polyketides from the Co-Cultivation of Marine-Derived Penicillium sp. WC-29-5 and Streptomyces fradiae 007

(2014) Yi Wang et al.   Marine Drugs

Marine bacteria from the Roseobacter clade produce sulfur volatiles via amino acid and dimethylsulfoniopropionate catabolism

(2014) Nelson L. Brock et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exo-Metabolome of Pseudovibrio sp. FO-BEG1 Analyzed by Ultra-High Resolution Mass Spectrometry and the Effect of Phosphate Limitation

(2014) Stefano Romano et al.   PLoS One

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

(2014) M. R. Seyedsayamdost   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brominated resorcylic acid lactones from the marine-derived fungus Cochliobolus lunatus induced by histone deacetylase inhibitors

(2014) Wei Zhang et al.   TETRAHEDRON LETTERS

The genusPseudovibriocontains metabolically versatile bacteria adapted for symbiosis

(2013) Vladimir Bondarev et al.   ENVIRONMENTAL MICROBIOLOGY

Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi

(2013) Wilna J. Moree et al.   JOURNAL OF CHEMICAL ECOLOGY

Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements

(2013) Kozo Ochi et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Sorbicillamines A–E, Nitrogen-Containing Sorbicillinoids from the Deep-Sea-Derived Fungus Penicillium sp. F23–2

(2013) Wenqiang Guo et al.   JOURNAL OF NATURAL PRODUCTS

Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin

(2013) Sara Palomo et al.   Marine Drugs

Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills

(2013) Sherif I. Elshahawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Andrimid production at low temperature by a psychrotolerant Serratia proteamaculans strain

(2013) Leandro A. Sánchez et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Symbiotic Cooperation in the Biosynthesis of a Phytotoxin

(2012) Kirstin Scherlach et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diverse Secondary Metabolites Produced by Marine-Derived Fungus Nigrospora sp. MA75 on Various Culture Media

(2012) Zhuo Shang et al.   CHEMISTRY & BIODIVERSITY

Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp. SCSIO F063

(2012) Hongbo Huang et al.   JOURNAL OF NATURAL PRODUCTS

Regulation of fungal secondary metabolism

(2012) Axel A. Brakhage   NATURE REVIEWS MICROBIOLOGY

A novel conico-cylindrical flask aids easy identification of critical process parameters for cultivation of marine bacteria

(2011) Sayani Mitra et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biosynthesis of the Siderophore Rhodochelin Requires the Coordinated Expression of Three Independent Gene Clusters inRhodococcus jostiiRHA1

(2011) Mattia Bosello et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effects of High Salt Stress on Secondary Metabolite Production in the Marine-Derived Fungus Spicaria elegans

(2011) Yi Wang et al.   Marine Drugs

Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium

(2011) Yi Wang et al.   Marine Drugs

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

(2011) Gilles P. van Wezel et al.   NATURAL PRODUCT REPORTS

NRPS Substrate Promiscuity Diversifies the Xenematides

(2011) Jason M. Crawford et al.   ORGANIC LETTERS

Chitin stimulates production of the antibiotic andrimid in a Vibrio coralliilyticus strain

(2011) Matthias Wietz et al.   Environmental Microbiology Reports

A case study on chemical defense based on quorum sensing: antibacterial activity of sponge-associated bacterium Pseudoalteromonas sp. NJ6-3-1 induced by quorum sensing mechanisms

(2010) Xiuchun Guo et al.   ANNALS OF MICROBIOLOGY

Antibacterials from the Sea

(2010) Chambers C. Hughes et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cross-Species Induction of Antimicrobial Compounds, Biosurfactants and Quorum-Sensing Inhibitors in Tropical Marine Epibiotic Bacteria by Pathogens and Biofouling Microorganisms

(2010) Devendra H. Dusane et al.   CURRENT MICROBIOLOGY

Carbon source regulation of antibiotic production

(2010) Sergio Sánchez et al.   JOURNAL OF ANTIBIOTICS

Expression of Tropodithietic Acid Biosynthesis Is Controlled by a Novel Autoinducer

(2010) H. Geng et al.   JOURNAL OF BACTERIOLOGY

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

(2010) Keishi Ishida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

(2010) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

Histone Deacetylase Inhibitors as a Tool to Up-Regulate New Fungal Biosynthetic Products: Isolation of EGM-556, a Cyclodepsipeptide, fromMicroascussp.

(2010) Hélène C. Vervoort et al.   ORGANIC LETTERS

Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces

(2010) Juan F Martín et al.   Microbial Biotechnology

Production of a potentially novel antimicrobial compound by a biofilm-forming marine Streptomyces sp. in a niche-mimic rotating disk bioreactor

(2009) Sreyashi Sarkar et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Spicochalasin A and New Aspochalasins from the Marine-Derived FungusSpicaria elegans

(2009) Zhenjian Lin et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cell–cell signalling in bacteria: not simply a matter of quorum

(2009) Mickaël Boyer et al.   FEMS MICROBIOLOGY ECOLOGY

Microbial drug discovery: 80 years of progress

(2009) Arnold L Demain et al.   JOURNAL OF ANTIBIOTICS

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

(2009) Robert H. Cichewicz   NATURAL PRODUCT REPORTS