Identification of Compounds with Anti-Proliferative Activity against Trypanosoma brucei brucei Strain 427 by a Whole Cell Viability Based HTS Campaign

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

(2011) Robert T. Jacobs et al.   PLoS Neglected Tropical Diseases

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

(2010) B. Nare et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

(2010) Deuan C. Jones et al.   BIOCHEMICAL PHARMACOLOGY

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical shift assignment and conformational analysis of monoalkylated acylguanidines

(2010) Roland Kleinmaier et al.   MAGNETIC RESONANCE IN CHEMISTRY

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

(2010) Elizabeth R. Sharlow et al.   PLoS Neglected Tropical Diseases

The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases

(2010) Pere P Simarro et al.   International Journal of Health Geographics

Development of an Alamar Blue™ Viability Assay in 384-Well Format for High Throughput Whole Cell Screening of Trypanosoma brucei brucei Bloodstream Form Strain 427

(2009) Melissa L. Sykes et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Trypanocidal drugs: mechanisms, resistance and new targets

(2009) Shane R. Wilkinson et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Characterization of the Two Fundamental Conformations of Benzoylureas and Elucidation of the Factors That Facilitate Their Conformational Interchange

(2009) Guillaume Lessene et al.   JOURNAL OF ORGANIC CHEMISTRY

NECT trial: more than a small victory over sleeping sickness

(2009) Jimmy Opigo et al.   LANCET

The Burden of Human African Trypanosomiasis

(2009) Eric M. Fèvre et al.   PLoS Neglected Tropical Diseases

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

(2008) Jean E. Bemis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS